Zobrazeno 1 - 10
of 669
pro vyhledávání: '"Cheryl H Arrowsmith"'
Autor:
Shengrui Feng, Sajid A. Marhon, Dustin J. Sokolowski, Alister D’Costa, Fraser Soares, Parinaz Mehdipour, Charles Ishak, Helen Loo Yau, Ilias Ettayebi, Parasvi S. Patel, Raymond Chen, Jiming Liu, Philip C. Zuzarte, King Ching Ho, Ben Ho, Shiyao Ning, Annie Huang, Cheryl H. Arrowsmith, Michael D. Wilson, Jared T. Simpson, Daniel D. De Carvalho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been fully elucidated. We found that the sensitivity of ATRTs to EZH2 inhibition (EZH
Externí odkaz:
https://doaj.org/article/0d1e7015e2c14b349eee324205203761
Autor:
Joseph Walton, Angel S. N. Ng, Karen Arevalo, Anthony Apostoli, Jalna Meens, Christina Karamboulas, Jonathan St-Germain, Panagiotis Prinos, Julia Dmytryshyn, Eric Chen, Cheryl H. Arrowsmith, Brian Raught, Laurie Ailles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In addition to the ubiquitous loss of the VHL gene in clear cell renal cell carcinoma (ccRCC), co-deletions of chromatin-regulating genes are common drivers of tumorigenesis, suggesting potential vulnerability to epigenetic manipulation. A l
Externí odkaz:
https://doaj.org/article/c3c9ce48e93f480088b52266f80ffb05
Autor:
Lena Münzker, Serah W. Kimani, Milan M. Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M. Zak, Anthony K. L. Leung, Jonathan M. Elkins, Dirk Kessler, Cheryl H. Arrowsmith, Levon Halabelian, Jark Böttcher
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The WWE domain is a relatively under-researched domain found in twelve human proteins and characterized by a conserved tryptophan-tryptophan-glutamate (WWE) sequence motif. Six of these WWE domain-containing proteins also contain domains wit
Externí odkaz:
https://doaj.org/article/d563b7d731e84d30bedff15301871bf2
Autor:
Serah W. Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Cbl-b is a RING-type E3 ubiquitin ligase that is expressed in several immune cell lineages, where it negatively regulates the activity of immune cells. Cbl-b has specifically been identified as an attractive target for cancer immunotherapy d
Externí odkaz:
https://doaj.org/article/cb03406153a543aca75baa69d0a3b0e3
Autor:
Kate M. MacDonald, Shirony Nicholson-Puthenveedu, Maha M. Tageldein, Sarika Khasnis, Cheryl H. Arrowsmith, Shane M. Harding
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
DNA damage-induced micronuclei are linked to downstream viral signalling through the cGAS pattern recognition receptor. Here, the authors identify features of micronuclei chromatin that determine cGAS-MN recruitment and associated pathway activation.
Externí odkaz:
https://doaj.org/article/6975b4b189014a4d93a5b9772b472477
Autor:
Tamuka M. Chidyausiku, Soraia R. Mendes, Jason C. Klima, Marta Nadal, Ulrich Eckhard, Jorge Roel-Touris, Scott Houliston, Tibisay Guevara, Hugh K. Haddox, Adam Moyer, Cheryl H. Arrowsmith, F. Xavier Gomis-Rüth, David Baker, Enrique Marcos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The immunoglobulin domain framework of antibodies has been a long standing design challenge. Here, the authors describe design rules for tailoring these domains and show they can be accurately designed, de novo, with high stability and the ability to
Externí odkaz:
https://doaj.org/article/97a8dd6f14d04e56ae09b84b09e5515d
Autor:
Tiago S. Medina, Alex Murison, Michelle Smith, Gabriela S. Kinker, Ankur Chakravarthy, Glauco A. F. Vitiello, Williams Turpin, Shu Yi Shen, Helen L. Yau, Olga F. Sarmento, William Faubion, Mathieu Lupien, Mark S. Silverberg, Cheryl H. Arrowsmith, Daniel D. De Carvalho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe imbalance between Th17 and regulatory T cells in inflammatory bowel diseases (IBD) promotes intestinal epithelial cell damage. In this scenario, T helper cell lineage commitment is accompanied by dynamic changes to the chromatin that
Externí odkaz:
https://doaj.org/article/48032f330d2f4012b81f6e5ecfa9adc0
Autor:
Rachel J. Harding, Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle, Magdalena M. Szewczyk, Nola Begeja, Siobhan Goss, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B. Carroll, Albert J. R. Heck, Susan M. Lea, Cheryl H. Arrowsmith
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Harding et al. present a biophysical and structural characterization of the complex between huntingtin (HTT) and HAP40 proteins. They show that the abundance of HAP40 is coupled with that of HTT and that there is greater conformational variety in the
Externí odkaz:
https://doaj.org/article/eb1fd59dd9ce42829c1dde1a83e58ffc
Autor:
Patty Sachamitr, Jolene C. Ho, Felipe E. Ciamponi, Wail Ba-Alawi, Fiona J. Coutinho, Paul Guilhamon, Michelle M. Kushida, Florence M. G. Cavalli, Lilian Lee, Naghmeh Rastegar, Victoria Vu, María Sánchez-Osuna, Jasmin Coulombe-Huntington, Evgeny Kanshin, Heather Whetstone, Mathieu Durand, Philippe Thibault, Kirsten Hart, Maria Mangos, Joseph Veyhl, Wenjun Chen, Nhat Tran, Bang-Chi Duong, Ahmed M. Aman, Xinghui Che, Xiaoyang Lan, Owen Whitley, Olga Zaslaver, Dalia Barsyte-Lovejoy, Laura M. Richards, Ian Restall, Amy Caudy, Hannes L. Röst, Zahid Quyoom Bonday, Mark Bernstein, Sunit Das, Michael D. Cusimano, Julian Spears, Gary D. Bader, Trevor J. Pugh, Mike Tyers, Mathieu Lupien, Benjamin Haibe-Kains, H. Artee Luchman, Samuel Weiss, Katlin B. Massirer, Panagiotis Prinos, Cheryl H. Arrowsmith, Peter B. Dirks
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in viv
Externí odkaz:
https://doaj.org/article/ce276d7ef43841fc91a953ffc3d02ecd
Autor:
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102282- (2022)
Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency
Externí odkaz:
https://doaj.org/article/8c9174ed85e342749dbc2bfff8c4fb40