Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Cheryl Gillet"'
Autor:
Rachel Evans, Fabian Flores-Borja, Sina Nassiri, Elena Miranda, Katherine Lawler, Anita Grigoriadis, James Monypenny, Cheryl Gillet, Julie Owen, Peter Gordon, Victoria Male, Anthony Cheung, Farzana Noor, Paul Barber, Rebecca Marlow, Erika Francesch-Domenech, Gilbert Fruhwirth, Mario Squadrito, Borivoj Vojnovic, Andrew Tutt, Frederic Festy, Michele De Palma, Tony Ng
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 1967-1978.e4 (2019)
Summary: Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular metastasis are poorly understood. We define a macrophage-dependent signaling cascade
Externí odkaz:
https://doaj.org/article/4742772908ef465eb5e9bd0d61b0e92a
Autor:
Nikhil Cherian Kurian, Amit Lehan, Gregory Verghese, Nimish Dharamshi, Swati Meena, Mengyuan Li, Fangfang Liu, Cheryl Gillet, Swapnil Rane, Anita Grigoriadis, Amit Sethi
Although the U-Net architecture has been extensively used for segmentation of medical images, we address two of its shortcomings in this work. Firstly, the accuracy of vanilla U-Net degrades when the target regions for segmentation exhibit significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca9e3bbc1891d1f6197f0339e90449e
http://arxiv.org/abs/2205.01777
http://arxiv.org/abs/2205.01777
Autor:
Beth Russell, Poppy Leech, Harriet Wylie, Charlotte Louise Moss, Anna Haire, Deborah Enting, Suzanne Amery, Kathryn Chatterton, Muhammad Shamim Khan, Ramesh Thurairaja, Rajesh Nair, Sachin Malde, Kate Smith, Cheryl Gillett, Debra Josephs, Elias Pintus, Sarah Rudman, Simon Hughes, Clare Relton, Mieke Van Hemelrijck
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
PurposeThe Graham Roberts Study was initiated in 2018 and is the first Trials Within Cohorts (TwiCs) study for bladder cancer. Its purpose is to provide an infrastructure for answering a breadth of research questions, including clinical, mechanistic,
Externí odkaz:
https://doaj.org/article/4b22b97093b047b19f688f0a5701018f
Autor:
James Spicer, Bristi Basu, Ana Montes, Udai Banerji, Rebecca Kristeleit, Rowan Miller, Gareth J. Veal, Christopher J. Corrigan, Stephen J. Till, Mariangela Figini, Silvana Canevari, Claire Barton, Paul Jones, Sarah Mellor, Simon Carroll, Chris Selkirk, George Nintos, Vineet Kwatra, Ionut-Gabriel Funingana, Gary Doherty, Hannah J. Gould, Giulia Pellizzari, Mano Nakamura, Kristina M. Ilieva, Atousa Khiabany, Chara Stavraka, Jitesh Chauhan, Cheryl Gillett, Sarah Pinder, Heather J. Bax, Debra H. Josephs, Sophia N. Karagiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT025
Externí odkaz:
https://doaj.org/article/10c6fe5134614037a52da348794ee12d
Autor:
Julie Owen, Nikhil Cherian, Swati Meena, Anita Grigoriadis, Cheryl Gillet, Amit Lohan, Ed Martin, Amit Sethi, Tristan Clark, Swapnil Rane, Gregory Verghese, Fangfang Liu, Harry Chinque
Publikováno v:
Clinical Cancer Research. 27:PO-014
Background Histological changes in the cancer-free lymph nodes (LNs) can add to the risk prediction of developing distant metastasis for LN-positive breast cancer patients. We have previously shown that the formation of germinal centres and enlarged
Autor:
Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman, Claire M. Wells
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Invadopodia, actin-rich structures that release metallo-proteases at the interface with extra-cellular matrix, in a punctate manner are thought to be important drivers of tumour invasion. Invadopodia formation has been observed in
Externí odkaz:
https://doaj.org/article/8fa0d54a37554369a610152247a40796
Autor:
Andrew Tutt, Benjamin Haibe-Kains, Marc Buyse, Cheryl Gillet, Christine Desmedt, Jonas Bergh, Françoise Lallemand, Denis Larsimont, Jan Klijn, Christos Sotiriou, John A. Foekens, Mauro Delorenzi, Paul Ellis, Martine Piccart, Adrian L. Harris, Gianluca Bontempi, Sherene Loi
Publikováno v:
Journal of Clinical Oncology, 25(10), 1239-1246. American Society of Clinical Oncology
Purpose A number of microarray studies have reported distinct molecular profiles of breast cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although
Autor:
Frances Downey, Nicholas Cade, Richard Cook, Robert Springall, Cheryl Gillet, David Richards, Frederic Festy, Beverly Karplus Hartline, Renee K. Horton, Catherine M. Kaicher
Publikováno v:
AIP Conference Proceedings.
Formalin‐fixed, paraffin‐embedded (FFPE) sections of breast tissue are used by pathologists to correctly type and grade the primary tumor and to assess the extent of a patient’s disease. The cut sections represent a reproducible likeness of the
Autor:
Julia Stevenson, Rachel Barrow-McGee, Lu Yu, Angela Paul, David Mansfield, Julie Owen, Natalie Woodman, Rachael Natrajan, Syed Haider, Cheryl Gillett, Andrew Tutt, Sarah E. Pinder, Jyoti Choudary, Kalnisha Naidoo
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract In breast cancer (BC), detecting low volumes of axillary lymph node (ALN) metastasis pre-operatively is difficult and novel biomarkers are needed. We recently showed that patient-derived ALNs can be sustained ex-vivo using normothermic perfu
Externí odkaz:
https://doaj.org/article/faec4d711cb34b769d96bb88a3e5b5c2
Autor:
Mauro Delorenzi, Cheryl Gillet, Benjamin Haibe-Kains, Maria Grazia Daidone, Els M.J.J. Berns, Pratyaksha Wirapati, Paul Ellis, John A. Foekens, Andrew Tutt, Christos Sotiriou, Françoise Lallemand, Kenneth Ryder, Sherene Loi, Maurice P.H.M. Jansen, Christine Desmedt, M. A. Pierotti, James F. Reid, Martine Piccart, Gianluca Bontempi
Publikováno v:
BMC Genomics
BMC genomics, 9
BMC Genomics, Vol 9, Iss 1, p 239 (2008)
Bmc Genomics, vol. 9, pp. 239
BMC Genomics, 9. BioMed Central Ltd.
BMC genomics, 9
BMC Genomics, Vol 9, Iss 1, p 239 (2008)
Bmc Genomics, vol. 9, pp. 239
BMC Genomics, 9. BioMed Central Ltd.
BACKGROUND: Estrogen receptor positive (ER+) breast cancers (BC) are heterogeneous with regard to their clinical behavior and response to therapies. The ER is currently the best predictor of response to the anti-estrogen agent tamoxifen, yet up to 30