Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Cheryl Galindo"'
1
Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms
Autor: Matthew McMillin, Hae Yong Pae, Gabriel Frampton, Sharon DeMorrow, Matthew A. Quinn, Cheryl Galindo
Publikováno v: Digestive and Liver Disease. 46:527-534
Background The blood brain barrier tightly regulates the passage of molecules into the brain and becomes leaky following obstructive cholestasis. The aim of this study was to determine if increased serum bile acids observed during cholestasis permeab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec4d2819c9c63d66d8180ae5e40a56fd
https://doi.org/10.1016/j.dld.2014.01.159
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2
The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1
Autor: Cheryl Galindo, Matthew McMillin, Hae Yong Pae, Gabriel Frampton, Sharon DeMorrow, Matthew A. Quinn, Dinorah Leyva-Illades, Yoshiyuki Ueno
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G1202-G1211
Progranulin (PGRN), a secreted growth factor, regulates the proliferation of various epithelial cells. Its mechanism of action is largely unknown. Sirtuin 1 (Sirt1) is a protein deacetylase that is known to regulate the transcriptional activity of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f523e5cffa839d8e0ff9018425e4279
https://doi.org/10.1152/ajpgi.00104.2012
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3
Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat
Autor: Matthew A. Quinn, Matthew McMillin, Li Huang, Hae Yong Pae, Heather Francis, Sharon DeMorrow, Gabriel Frampton, Yoshiyuki Ueno, Cheryl Galindo, Darijana Horvat
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G182-G193
Cholestatic patients often present with clinical features suggestive of adrenal insufficiency. In the bile duct-ligated (BDL) model of cholestasis, the hypothalamic-pituitary-adrenal (HPA) axis is suppressed. The consequences of this suppression on c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b135b658b594a088a8e438b3d85916
https://doi.org/10.1152/ajpgi.00205.2011
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4
Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism
Autor: Sharon DeMorrow, Brandon Cooper, Lorenza Rimassa, Cheryl Galindo, Darijana Horvat, Li Huang, Matthew A. Quinn, Matthew McMillin, Gabriel Frampton, Hae Yong Pae, Francesca Bernuzzi, Pietro Invernizzi
Publikováno v: Gut. 61:268-277
Background and objectives Cholangiocarcinoma is a devastating cancer of biliary origin with limited treatment options. The growth factor, progranulin, is overexpressed in a number of tumours. The study aims were to assess the expression of progranuli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aced780f78f88e8d1428b3dc6caf4f73
https://doi.org/10.1136/gutjnl-2011-300643
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5
Gli1 Activation and Protection Against Hepatic Encephalopathy is Suppressed by Circulating Transforming Growth Factor β1 in Mice
Autor: Sharon DeMorrow, Eric Whittington, Gabriel Frampton, Matthew McMillin, Cheryl Galindo, Hae Yong Pae, Matthew A. Quinn, Pier Luigi Di Patre
Background & Aims Hepatic encephalopathy (HE) is a neurologic disorder that develops during liver failure. Few studies exist investigating systemic-central signalling during HE outside of inflammatory signalling. The transcription factor Gli1, which
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5906eb22352602b4f173f544bdf64f16
https://europepmc.org/articles/PMC4253574/
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