Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Cheryl G. Pfeifer"'
Autor:
Clara Wenjing Xia, Iryna Saranchova, Pablo L. Finkel, Stephanie Besoiu, Lonna Munro, Cheryl G. Pfeifer, Anne Haegert, Yen-Yi Lin, Stéphane Le Bihan, Colin Collins, Wilfred A. Jefferies
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis. Additionally, in a role that has garnered considerably less attention,
Externí odkaz:
https://doaj.org/article/8854a3ed87764c5097f60d12e326c0ff
Autor:
Iryna Saranchova, Clara Wenjing Xia, Stephanie Besoiu, Pablo L. Finkel, Samantha L. S. Ellis, Suresh Kari, Lonna Munro, Cheryl G. Pfeifer, Ladan Fazli, Martin E. Gleave, Wilfred A. Jefferies
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cell-based cancer immunotherapy has achieved significant advancements, providing a source of hope for cancer patients. Notwithstanding the considerable progress in cell-based immunotherapy, the persistently low response rates and the exorbitant costs
Externí odkaz:
https://doaj.org/article/84770b6c7e8544bcacd0fa5532f52bcb
Autor:
Brett A. Eyford, Maciej J. Lazarczyk, Kyung Bok Choi, Merina Varghese, Hitesh Arora, Suresh Kari, Lonna Munro, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Dara L. Dickstein, Wilfred A. Jefferies
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The interplay between AMPA-type glutamate receptors (AMPARs) and major histocompatibility complex class I (MHC-I) proteins in regulating synaptic signaling is a crucial aspect of central nervous system (CNS) function. In this study, we inves
Externí odkaz:
https://doaj.org/article/b13129d68b9c4a1ab46349a7afd15b09
Autor:
Samantha L. S. Ellis, Lilian L. Nohara, Sarah Dada, Iryna Saranchova, Lonna Munro, Kyung Bok Choi, Emmanuel Garrovillas, Cheryl G. Pfeifer, David E. Williams, Ping Cheng, Raymond J. Andersen, Wilfred A. Jefferies
Publikováno v:
Frontiers in Natural Products, Vol 2 (2023)
One of the primary obstacles in current cancer treatments lies in the extensive heterogeneity of genetic and epigenetic changes that occur in each arising tumour. However, an additional challenge persists, as certain types of cancer display shared im
Externí odkaz:
https://doaj.org/article/52baee5274d346a0a2d145329af11432
Autor:
Maciej J. Lazarczyk, Brett A. Eyford, Merina Varghese, Hitesh Arora, Lonna Munro, Tahia Warda, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Timothy Rumbell, Wilfred A. Jefferies, Dara L. Dickstein
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Major histocompatibility complex class I (MHC-I) proteins are expressed in neurons, where they regulate synaptic plasticity. However, the mechanisms by which MHC-I functions in the CNS remains unknown. Here we describe the first structural a
Externí odkaz:
https://doaj.org/article/efb7fabefb7e4b9fb5bff7fbd1571479
Autor:
Samantha L. S. Ellis, Sarah Dada, Lilian L. Nohara, Iryna Saranchova, Lonna Munro, Cheryl G. Pfeifer, Brett A. Eyford, Tunc Morova, David E. Williams, Ping Cheng, Nathan A. Lack, Raymond J. Andersen, Wilfred A. Jefferies
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Curcuphenol, a common component of the culinary spices, naturally found in marine invertebrates and plants, has been identified as a novel candidate for reversing immune escape by restoring expression of the antigen presentation machinery (APM) in in
Externí odkaz:
https://doaj.org/article/e6ea2b93d205450ca96c6cc33511b8e2
Autor:
Lilian L. Nohara, Samantha L. S. Ellis, Carola Dreier, Sarah Dada, Iryna Saranchova, Kyong Bok Choi, Lonna Munro, Cheryl G. Pfeifer, Eliana Al Haddad, Krysta M. Coyle, Jessica R. Morrice, Daniel Joo Sung Shim, Paul Ahn, Nicole De Voogd, David E. Williams, Ping Cheng, Emmanuel Garrovillas, Raymond J. Andersen, Wilfred A. Jefferies
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Genetic and epigenetic events have been implicated in the downregulation of the cellular antigen processing and presentation machinery (APM), which in turn, has been associated with cancer evasion of the immune system. When these essential components
Externí odkaz:
https://doaj.org/article/1a57b6de364940ccb9aa328fe388ec42
Autor:
Sarah Dada, Samantha L. S. Ellis, Christi Wood, Lilian L. Nohara, Carola Dreier, Nicolas H. Garcia, Iryna Saranchova, Lonna Munro, Cheryl G. Pfeifer, Brett A. Eyford, Suresh Kari, Emmanuel Garrovillas, Giorgia Caspani, Eliana Al Haddad, Patrick W. Gray, Tunc Morova, Nathan A. Lack, Raymond J. Andersen, Larry Tjoelker, Wilfred A. Jefferies
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Emerging cancers are sculpted by neo-Darwinian selection for superior growth and survival but minimal immunogenicity; consequently, metastatic cancers often evolve common genetic and epigenetic signatures to elude immune surveillance. Immune subversi
Externí odkaz:
https://doaj.org/article/9ef704380f1b4fca8eab24f38e67eb02
Autor:
Pablo de Lucía Finkel, Christopher Sherwood, Iryna Saranchova, Wenjing Xia, Lonna Munro, Cheryl G. Pfeifer, James M. Piret, Wilfred A. Jefferies
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Type 2 innate lymphoid cells (ILC2s) were discovered approximately ten years ago and their clinical relevance is gaining greater importance. However, their successful isolation from mammalian tissues and in vitro culture and expansion contin
Externí odkaz:
https://doaj.org/article/96f8a16afbfc41198379d0874751a533
Autor:
Chaahat S.B. Singh, Kyung Bok Choi, Lonna Munro, Hong Yue Wang, Cheryl G. Pfeifer, Wilfred A. Jefferies
Publikováno v:
EBioMedicine, Vol 71, Iss , Pp 103503- (2021)
Background: Cognitive decline leading to dementia, accompanied by the accumulation of amyloid-beta (Aβ) in neuritic plaques together with the appearance of neurofibrillary tangles (NFT) composed of hyperphosphorylated tau protein (tau), are previous
Externí odkaz:
https://doaj.org/article/a30097a5a60742fda81afe99826be5fb