Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Cheryl D. Schwartz"'
Autor:
Meng-Hsin Chen, Chris M. Thompson, Dennis M. Zaller, Suresh B. Singh, Patricia Fitzgerald, Edward A. O'Neill, James B. Doherty, Stephen J. O'Keefe, Cheryl D. Schwartz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2222-2226
Synthesis and biological activities of some quinolinone and dihydroquinolinone p38 MAP kinase inhibitors are reported. Modifications to the dihydroquinolinone pharmacophore revealed that dihydroquinolinone may be replaced with a quinolinone pharmacop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c9b2365e908ca07efdcf2beb5369c6
https://doi.org/10.1016/j.bmcl.2006.10.097
https://doi.org/10.1016/j.bmcl.2006.10.097
Autor:
James V. Pivnichny, Luping Liu, Elizabeth A. Nichols, Dennis M. Zaller, Zhen Wang, Chris M. Thompson, Dennis M. Schmatz, Stephen J. O'Keefe, Suresh B. Singh, Cheryl D. Schwartz, Cornelis E. C. A. Hop, John R. Strauss, Sangita B. Patel, John E. Stelmach, Edward A. O'Neill, Patricia M. Cameron, James B. Doherty, Giovanna Scapin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:277-280
The development of potent, orally bioavailable (in rat) and selective dihydroquinazolinone inhibitors of p38alpha MAP kinase is described. These analogues are hybrids of a pyridinylimidazole p38alpha inhibitor reported by Merck Research Laboratories
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e7da4d75d75875462d69354daca7bd
https://doi.org/10.1016/s0960-894x(02)00752-7
https://doi.org/10.1016/s0960-894x(02)00752-7
Autor:
Swaminathan R. Natarajan, Cheryl D. Schwartz, Chris M. Thompson, Suresh B. Singh, Dennis M. Schmatz, Stephen J. O'Keefe, Dennis M. Zaller, Sanjeev Kumar, Catherine E. Fitzgerald, Cornelis E. C. A. Hop, Edward A. O'Neill, David D. Wisnoski, John E. Stelmach, James B. Doherty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:273-276
A new class of p38 antagonists based on 3,4-dihydropyrido[3,2,-d]pyrimidine scaffold has been developed. These inhibitors exhibit unprecedented selectivity towards p38 over other very closely related kinases. Compounds 25, 33, and 34 were identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8d01bf7b45396613cd4314e2031f2d
https://doi.org/10.1016/s0960-894x(02)00876-4
https://doi.org/10.1016/s0960-894x(02)00876-4
Autor:
Cheryl D. Schwartz, Edward A. O'Neill, David A. Claremon, Nigel J. Liverton, Gerald S. Ponticello, Stephen J. O'Keefe, Margaret Pang, Charles J. Mcintyre
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:689-692
Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38 MAPK. The most active isomers were those possessing an aryl group α and a heteroaryl group β relative to the nitrogen atom in the 2-position of the central pyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90622e9ba42ce5aa13a13887bc36b694
https://doi.org/10.1016/s0960-894x(01)00834-4
https://doi.org/10.1016/s0960-894x(01)00834-4
Autor:
Jeffrey D. Hermes, Winston Yuen, Alan D. Adams, John J. Acton, Elizabeth A. Nichols, A. Brian Jones, Linda S. Wicker, Cheryl D. Schwartz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2115-2118
Tetrapeptide derived major histocompatability (MHC) II ligands have been developed that contain no unadulterated peptide bonds. These are the 'least peptidic' ligands for any MHC protein yet reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0538d5d8bb5db7f66b7b8d0d0572f5
https://doi.org/10.1016/s0960-894x(99)00334-0
https://doi.org/10.1016/s0960-894x(99)00334-0
Autor:
Jeffrey D. Hermes, Cheryl D. Schwartz, Linda S. Wicker, Barry R. Cunningham, Meheryar N. Rivetna, Elizabeth A. Nichols, Stacey J Flattery, A. Brian Jones, Richard L. Tolman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:19-24
Comparison of SAR for a tetrapeptide inhibitor of MHC class II with existing information endorses a binding mode consistent with naturally loaded full length peptides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f48da72b3571695171c48e5c0e58cb99
https://doi.org/10.1016/s0960-894x(96)00579-3
https://doi.org/10.1016/s0960-894x(96)00579-3
Autor:
Charles J. Mcintyre, David A. Claremon, Cheryl D. Schwartz, Margaret Pang, Edward A. O'Neill, Gerald S. Ponticello, Nigel J. Liverton, Stephen J. O'Keefe
Publikováno v:
ChemInform. 33
Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38 MAPK. The most active isomers were those possessing an aryl group α and a heteroaryl group β relative to the nitrogen atom in the 2-position of the central pyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8cf08aba2a53990450cecfbed83293e
https://doi.org/10.1002/chin.200226161
https://doi.org/10.1002/chin.200226161
Autor:
Martin S. Springer, Cheryl D. Schwartz, Susan M. Lindenmayer, Carl F. Homnick, H. B. Woodruff, Deborah L. Zink, Barbara Weissberger, Susan S. Honeycutt, Lauretta Zitano, Sara A. Currie, Lawrence R. Koupal, Thomas E. Rollins, James P. Springer, Akber A. Haidri, Jill M. Fieldhouse, Robert P. Borris, Charles G. Caldwell, Otto D. Hensens
Publikováno v:
The Journal of Antibiotics. 44:249-254
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e7941f0336b36b60e6a42469ab82fd
https://doi.org/10.7164/antibiotics.44.249
https://doi.org/10.7164/antibiotics.44.249
Autor:
H. Boyd Woodruff, Kristine A. Faust, Deborah L. Zink, Sara A. Currie, George M. Garrity, Raymond S.L. Chang, Debra Bogen, Otto D. Hensens, Magda M. Gagliardi, Loretta Zitano, Cheryl D. Schwartz, Y. K. Tony Lam
Publikováno v:
The Journal of Antibiotics. 44:613-625
The discovery and physico-chemical characterization of three novel and minor virginiamycin M1 analogs as potent gastrin antagonists from a culture of a strain of Streptomyces olivaceus are described. These analogs are L-156,586, L-156,587 and L-156,5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92012d08323d489cfd2b11ee676b022
https://doi.org/10.7164/antibiotics.44.613
https://doi.org/10.7164/antibiotics.44.613
Autor:
Catherine E. Fitzgerald, Ruixiu Wang, Elizabeth C. Dixon, Dennis M. Schmatz, Stephen J. O'Keefe, James B. Doherty, Jessica Frie, Cheryl D. Schwartz, Dennis M. Zaller, Chris M. Thompson, Gene Porter, Giovanna Scapin, James E. Thompson, Wesley L. Shoop, Suresh B. Singh, Andrea Woods, Elizabeth A. Nichols, Koppara Samuel, Edward A. O'Neill, Bernard K. Choi, Steven L. Colletti, Sanjeev Kumar
Publikováno v:
Journal of medicinal chemistry. 46(3)
Imidazo[1,2-a]pyridyl N-arylpyridazinones were hybridized from the classic pyridinylimidazoles and the more recent dual hydrogen bond acceptors, resulting in a new structural class of selective p38 MAP kinase inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dc042f915b17dfb9b10eebd7138978
https://pubmed.ncbi.nlm.nih.gov/12540232
https://pubmed.ncbi.nlm.nih.gov/12540232