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Akademický článek

The transcriptional co-regulator LDB1 is required for brown adipose function

Autor: Jessica D. Kepple, Yanping Liu, Teayoun Kim, Cheryl Cero, James W. Johnson, Glenn C. Rowe, Aaron M. Cypess, Kirk M. Habegger, Martin Young, Chad S. Hunter

Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101284- (2021)

Objective: Brown adipose tissue (BAT) is critical for thermogenesis and glucose/lipid homeostasis. Exploiting the energy uncoupling capacity of BAT may reveal targets for obesity therapies. This exploitation requires a greater understanding of the tr

Externí odkaz: https://doaj.org/article/fa6c61723738419489af22749dacd08d

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Akademický článek

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

Autor: Cheryl Cero, Hannah J. Lea, Kenneth Y. Zhu, Farnaz Shamsi, Yu-Hua Tseng, Aaron M. Cypess

Publikováno v: JCI Insight, Vol 6, Iss 11 (2021)

β3-Adrenergic receptors (β3-ARs) are the predominant regulators of rodent brown adipose tissue (BAT) thermogenesis. However, in humans, the physiological relevance of BAT and β3-AR remains controversial. Herein, using primary human adipocytes from

Externí odkaz: https://doaj.org/article/76331fef2122485d889d38be91fd6594

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Akademický článek

The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis

Autor: Cheryl Cero, Maria Razzoli, Ruijun Han, Bhavani Shankar Sahu, Jessica Patricelli, ZengKui Guo, Nathan A. Zaidman, John M. Miles, Scott M. O'Grady, Alessandro Bartolomucci

Publikováno v: Molecular Metabolism, Vol 6, Iss 1, Pp 148-158 (2017)

Objectives: Obesity is characterized by excessive fat mass and is associated with serious diseases such as type 2 diabetes. Targeting excess fat mass by sustained lipolysis has been a major challenge for anti-obesity therapies due to unwanted side ef

Externí odkaz: https://doaj.org/article/9d5329002d7743a1a150190e8b5f8441

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Akademický článek

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

Autor: Bhavani S. Sahu, Pedro Rodriguez, Megin E. Nguyen, Ruijun Han, Cheryl Cero, Maria Razzoli, Paolo Piaggi, Lauren J. Laskowski, Mihaela Pavlicev, Louis Muglia, Sushil K. Mahata, Scott O’Grady, John D. McCorvy, Leslie J. Baier, Yuk Y. Sham, Alessandro Bartolomucci

Publikováno v: Cell Reports, Vol 28, Iss 10, Pp 2567-2580.e6 (2019)

Summary: Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Even small changes in sequence can alter receptor activation, affecting therapeutic efficacy. We conducted a structure-function relationship st

Externí odkaz: https://doaj.org/article/fc9a6c02601348888afb15dee7ae18f6

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Akademický článek

Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis

Autor: Maria Razzoli, Andrea Frontini, Allison Gurney, Eleonora Mondini, Cankut Cubuk, Liora S. Katz, Cheryl Cero, Patrick J. Bolan, Joaquin Dopazo, Antonio Vidal-Puig, Saverio Cinti, Alessandro Bartolomucci

Publikováno v: Molecular Metabolism, Vol 5, Iss 1, Pp 19-33 (2016)

Background: Stress-associated conditions such as psychoemotional reactivity and depression have been paradoxically linked to either weight gain or weight loss. This bi-directional effect of stress is not understood at the functional level. Here we te

Externí odkaz: https://doaj.org/article/143aa405ddc2429ea38334eb4c53e482

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Akademický článek

Loss of Gnas imprinting differentially affects REM/NREM sleep and cognition in mice.

Autor: Glenda Lassi, Simon T Ball, Silvia Maggi, Giovanni Colonna, Thierry Nieus, Cheryl Cero, Alessandro Bartolomucci, Jo Peters, Valter Tucci

Publikováno v: PLoS Genetics, Vol 8, Iss 5, p e1002706 (2012)

It has been suggested that imprinted genes are important in the regulation of sleep. However, the fundamental question of whether genomic imprinting has a role in sleep has remained elusive up to now. In this work we show that REM and NREM sleep stat

Externí odkaz: https://doaj.org/article/cb233a91563c43488315d7ca8005298b

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Akademický článek

Metabolic consequences and vulnerability to diet-induced obesity in male mice under chronic social stress.

Autor: Alessandro Bartolomucci, Aderville Cabassi, Paolo Govoni, Graziano Ceresini, Cheryl Cero, Daniela Berra, Harold Dadomo, Paolo Franceschini, Giacomo Dell'Omo, Stefano Parmigiani, Paola Palanza

Publikováno v: PLoS ONE, Vol 4, Iss 1, p e4331 (2009)

Social and psychological factors interact with genetic predisposition and dietary habit in determining obesity. However, relatively few pre-clinical studies address the role of psychosocial factors in metabolic disorders. Previous studies from our la

Externí odkaz: https://doaj.org/article/aa8d9847684a493e8c92df796f083c81

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