Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Cheryl B. Le Grand"'
Autor:
Gloria C. Koo, Martin S. Springer, Lorraine Malkowitz, Douglas W. Kawka, Kang Cheng, Qi Luo, Serguei Stepaniants, Kenneth K. Wu, Irwin I. Singer, Jeffrey Yuan, Andrew S. Plump, Cheryl B. Le Grand, Jun Zhu, Milana Maletic, Samuel D. Wright, James M. Balkovec, Gloria J.-F. Ding, Sherman T. Waddell, Xia Yang, Rolf Thieringer, Kashmira Shah, Pek Yee Lum, Mingjuan Jane Luo, I-Ming Wang, Anne Hermanowski-Vosatka
Publikováno v:
Physiological Genomics. 45:47-57
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is implicated in the etiology of metabolic syndrome. We previously showed that pharmacological inhibition of 11β-HSD1 ameliorated multiple facets of metabolic syndrome and attenuated atheroscleros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62219a7783ded2299858a49a0cadc560
https://doi.org/10.1152/physiolgenomics.00109.2012
https://doi.org/10.1152/physiolgenomics.00109.2012
Autor:
Kang Cheng, Matthias Strowski, Jianying Xiao, Tsuei-Ju Wu, Ning Ren, Nancy Robertson, Martin S. Springer, Kenneth K. Wu, Zhihua Li, James M. Balkovec, Melba Hernandez, Howard Y. Chen, Cheryl B. Le Grand, Bill Pikounis, Anne Hermanowski-Vosatka, Joseph M. Metzger, Samuel D. Wright, Steven H. Olson, Alison M. Strack, Gloria C. Koo, Steven S. Mundt, Rolf Thieringer, Heather Noonan, Kashmira Shah, James M. Schaeffer, Christian N. Nunes, Bei B. Zhang
Publikováno v:
The Journal of Experimental Medicine
The enzyme 11β–hydroxysteroid dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising the effective glucocorticoid (GC) tone above serum levels. We report that pharmacologic inhibition of 11β-HSD1 has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2100c617c4f08e8bc6b622a8ee436ebe
http://europepmc.org/articles/PMC2212859
http://europepmc.org/articles/PMC2212859
Autor:
Tian-Quan Cai, Birming Wong, Anne Hermanowski-Vosatka, Rolf Thieringer, Linda Carbin, Cheryl B. Le Grand, Samuel D. Wright
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 167(1)
11β-hydroxysteroid dehydrogenases (11β-HSD) perform prereceptor metabolism of glucocorticoids through interconversion of the active glucocorticoid, cortisol, with inactive cortisone. Although the immunosuppressive and anti-inflammatory activities o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e773aeeac8e4a3916f37955bcc2ef0
https://pubmed.ncbi.nlm.nih.gov/11418628
https://pubmed.ncbi.nlm.nih.gov/11418628
Autor:
Rolf Thieringer, Joel P. Berger, Linda Carbin, Elizabeth P. Somers, David E. Moller, Beverly A. Shelton, Samuel D. Wright, Judy Fenyk-Melody, Cheryl B. Le Grand, Patricia A. Detmers
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 164(2)
We have investigated the potential use of peroxisome proliferator-activated receptor γ (PPARγ) agonists as anti-inflammatory agents in cell-based assays and in a mouse model of endotoxemia. Human peripheral blood monocytes were treated with LPS or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fa0f89e321b3827ce94a638047eb00
https://pubmed.ncbi.nlm.nih.gov/10623855
https://pubmed.ncbi.nlm.nih.gov/10623855