Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Cheryl Arrowsmith"'
Autor:
Jenny Ostrop, Rosalie T. Zwiggelaar, Marianne Terndrup Pedersen, François Gerbe, Korbinian Bösl, Håvard T. Lindholm, Alberto Díez-Sánchez, Naveen Parmar, Silke Radetzki, Jens Peter von Kries, Philippe Jay, Kim B. Jensen, Cheryl Arrowsmith, Menno J. Oudhoff
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Intestinal organoids are an excellent model to study epithelial biology. Yet, the selection of analytical tools to accurately quantify heterogeneous organoid cultures remains limited. Here, we developed a semi-automated organoid screening method, whi
Externí odkaz:
https://doaj.org/article/aecc2679ef1d45a8875277b91cd0b5d7
Autor:
Anne Hakem, Miyuki Bohgaki, Bénédicte Lemmers, Elisabeth Tai, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Yong-Sam Jung, Jana Karaskova, Lilia Kaustov, Shili Duan, Jason Madore, Paul Boutros, Yi Sheng, Marta Chesi, P Leif Bergsagel, Bayardo Perez-Ordonez, Anne-Marie Mes-Masson, Linda Penn, Jeremy Squire, Xinbin Chen, Igor Jurisica, Cheryl Arrowsmith, Otto Sanchez, Samuel Benchimol, Razqallah Hakem
Publikováno v:
PLoS Genetics, Vol 7, Iss 11, p e1002360 (2011)
Ubiquitylation is fundamental for the regulation of the stability and function of p53 and c-Myc. The E3 ligase Pirh2 has been reported to polyubiquitylate p53 and to mediate its proteasomal degradation. Here, using Pirh2 deficient mice, we report tha
Externí odkaz:
https://doaj.org/article/ceeccf61e253499a91010ab5fb3e09e2
Autor:
Abdellah Allali-Hassani, Wang Pan, Ludmila Dombrovski, Rafi Najmanovich, Wolfram Tempel, Aiping Dong, Peter Loppnau, Fernando Martin, Janet Thornton, Aled Edwards, Alexey Bochkarev, Alexander Plotnikov, Masoud Vedadi, Cheryl Arrowsmith
Publikováno v:
PLoS Biology, Vol 5, Iss 6 (2007)
Externí odkaz:
https://doaj.org/article/1ac138181d564978b8c903f4f1446a5a
Autor:
Serah Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
Cbl-b is a RING-type E3 ubiquitin ligase that is expressed in several immune cell lineages, where it negatively regulates the activity of immune cells. Cbl-b has specifically been identified as an attractive target for cancer immunotherapy due to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2db4dbbe02fc24621e78187a7f8d2166
https://doi.org/10.1101/2023.05.05.539612
https://doi.org/10.1101/2023.05.05.539612
Autor:
Anna Aakula, Mukund Sharma, Francesco Tabaro, Reetta Nätkin, Jesse Kamila, Henrik Honkanen, Matthieu Schapira, Cheryl Arrowsmith, Matti Nykter, Jukka Westermarck
RAS-mediated human cell transformation requires inhibition of the tumor suppressor protein phosphatase 2A (PP2A). However, the phosphoprotein targets and cellular processes in which RAS and PP2A activities converge in human cancers have not been syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971a49012655da7868b77c14ee29502c
https://trepo.tuni.fi/handle/10024/147274
https://trepo.tuni.fi/handle/10024/147274
Autor:
Anna Aakula, Mukund Sharma, Francesco Tabaro, Reetta Nätkin, Jesse Kamila, Henrik Honkanen, Matthieu Schapira, Cheryl Arrowsmith, Matti Nykter, Jukka Westermarck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e9d1b656bd8b2b764c5d466cf4d53ec
https://doi.org/10.15252/rc.2022436760
https://doi.org/10.15252/rc.2022436760
Autor:
Mukund Sharma, Anna Aakula, Francesco Tabaro, Henrik Honkanen, Jesse Kamila, Matthieu Schapira, Cheryl Arrowsmith, Matti Nykter, Jukka K. Westermarck
Publikováno v:
Cancer Research. 83:4727-4727
RAS-mediated human cell transformation requires inhibition of the tumor suppressor Protein Phosphatase 2A (PP2A). Both RAS and PP2A mediate their effects by phosphoregulation, but phosphoprotein targets in which RAS and PP2A activities converge in hu
Autor:
Khadija Jafarova, Panagiotis Prinos, Nikolina Radulovich, Takamasa Koga, Cheryl Arrowsmith, Geoffrey Liu, Ming Sound Tsao
Publikováno v:
Cancer Research. 83:4755-4755
Introduction: NSCLC is associated with high cancer-related mortality worldwide. Epigenetic modifications at the chromatin level have widely been linked to carcinogenesis. Epigenetic regulation not only contributes to the development of cancer, but it
Autor:
Anna Aakula, Mukund Sharma, Francesco Tabaro, Henrik Honkanen, Matthieu Schapira, Cheryl Arrowsmith, Matti Nykter, Jukka Westermarck
RAS-mediated human cell transformation requires inhibition of the tumor suppressor Protein Phosphatase 2A (PP2A). Both RAS and PP2A mediate their effects by phosphoregulation, but phosphoprotein targets and cellular processes in which RAS and PP2A ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7265276d49c6ac45bdf0376489097cd7
https://doi.org/10.1101/2022.05.11.491459
https://doi.org/10.1101/2022.05.11.491459
Autor:
Nicholas W. Fischer, Jaime Turk, Noel Ong, Shili Duan, Lilia Kaustov, Christian Kratz, Kristian Pajtler, Raymond Kim, Cheryl Arrowsmith, David Malkin
Publikováno v:
Cancer Research. 82:844-844
Pathogenic TP53 germline variants predispose carriers to a high lifelong cancer risk in Li-Fraumeni syndrome (LFS). LFS presents as a broad phenotypic spectrum with highly variable age-of-onset and tumor types. The mechanisms leading to these phenoty