Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Cheryl A. Rizzo"'
Autor:
Marco M. Gottardis, Robert Kramer, Gregory Vite, Shen-Jue Chen, Joseph Dinchuk, William R. Foster, Mark E. Salvati, Weifang Shan, Mary Obermeier, J. Suso Platero, Thomas E. Spires, Liang Schweizer, Cheryl A. Rizzo, Janet Dell-John, Mary Ellen Cvijic, Aaron Balog, Maria Jure-Kunkel, Ricardo M. Attar
Supplementary Table 1 from Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea96b450993c30817e08b09d67ecd09
https://doi.org/10.1158/0008-5472.22377966
https://doi.org/10.1158/0008-5472.22377966
Autor:
Marco M. Gottardis, Robert Kramer, Gregory Vite, Shen-Jue Chen, Joseph Dinchuk, William R. Foster, Mark E. Salvati, Weifang Shan, Mary Obermeier, J. Suso Platero, Thomas E. Spires, Liang Schweizer, Cheryl A. Rizzo, Janet Dell-John, Mary Ellen Cvijic, Aaron Balog, Maria Jure-Kunkel, Ricardo M. Attar
Supplementary Table 2 from Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77108c0dff54d0d9d17df83470660395
https://doi.org/10.1158/0008-5472.22377963.v1
https://doi.org/10.1158/0008-5472.22377963.v1
Autor:
Marco M. Gottardis, Robert Kramer, Gregory Vite, Shen-Jue Chen, Joseph Dinchuk, William R. Foster, Mark E. Salvati, Weifang Shan, Mary Obermeier, J. Suso Platero, Thomas E. Spires, Liang Schweizer, Cheryl A. Rizzo, Janet Dell-John, Mary Ellen Cvijic, Aaron Balog, Maria Jure-Kunkel, Ricardo M. Attar
Supplementary Figure and Table Legends 1-2 from Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c30c0ceeb3ee6de838292a026446d0
https://doi.org/10.1158/0008-5472.22377969
https://doi.org/10.1158/0008-5472.22377969
Autor:
Gregory D. Vite, Paul A. Elzinga, David L. Gold, Cheryl A. Rizzo, Thomas E. Spires, Sophie Beyer, Vanessa M. Spires, Marco M. Gottardis, George L. Trainor, Aberra Fura, Audris Huang, Gordon Todderud, John A. Newitt, Lata Jayaraman, Aaron Balog, Andrew J. Tebben, Yongxin Zhu, Mary T. Obermeier, Goodenough Angela, Bethanne M. Warrack, Arthur M. Doweyko, Yi Fan
Publikováno v:
ACS Medicinal Chemistry Letters. 7:40-45
Efforts to identify a potent, reversible, nonsteroidal CYP17A1 lyase inhibitor with good selectivity over CYP17A1 hydroxylase and CYPs 11B1 and 21A2 for the treatment of castration-resistant prostate cancer (CRPC) culminated in the discovery of BMS-3
Autor:
Janet Dell-John, John D. Dimarco, Cheryl A. Rizzo, Mark E. Salvati, Steven H. Spergel, Gregory Scott Martin, Weifang Shan, Aaron Balog, Georgia Cornelius, Richard Rampulla, Marco M. Gottardis, Andrew Nation, Christian L. Holst, Liang Schweizer, Gregory D. Vite, Lana M. Rossiter, Ricardo M. Attar, David J. Fairfax, Thomas E. Spires, Stanley R. Krystek, George L. Trainor, Jack Z. Gougoutas
Publikováno v:
ACS Medicinal Chemistry Letters. 6:908-912
BMS-641988 (23) is a novel, nonsteroidal androgen receptor antagonist designed for the treatment of prostate cancer. The compound has high binding affinity for the AR and acts as a functional antagonist in vitro. BMS-641988 is efficacious in multiple
Autor:
George L. Trainor, Andrew Nation, Ricardo M. Attar, Jun Dai, Xiao Zhu, Jing Chen, Mary T. Obermeier, Weifang Shan, Mary Ellen Cvijic, Gregory D. Vite, Cheryl A. Rizzo, Sarah C. Traeger, Michael Galella, Ashvinikumar V. Gavai, Thomas E. Spires, Aaron Balog, Yingru Zhang, Jieping Geng
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(23)
This letter describes the discovery, synthesis, SAR, and biological activity of [2.2.1]-bicyclic sultams as potent antagonists of the androgen receptor. Optimization of the series led to the identification of compound 25, which displayed robust pharm
Autor:
Hai-Yun Xiao, Jieping Geng, David J. Fairfax, Thomas E. Spires, Wen-Ching Han, Marco M. Gottardis, Mark E. Salvati, Andrew Nation, Weifang Shan, Mary-Ellen Cvjic, Jing Chen, Liang Schweizer, Mary T. Obermeier, Gregory Scott Martin, Ricardo M. Attar, Gregory D. Vite, Aaron Balog, Ashvinikumar V. Gavai, Janet Dell-John, Cheryl A. Rizzo, Lana M. Rossiter, Linda B. Fleming, Christian L. Holst
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4491-4495
A novel series of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles has been synthesized. The ability of these compounds to act as antagonists of the androgen receptor was investigated and several were fou
Autor:
Mary T. Obermeier, Mark E. Salvati, Michael Galella, Jack Z. Gougoutas, Ricardo M. Attar, Giese Soren, Stanley R. Krystek, Aaron Balog, Maria Jure-Kunkel, Gamini Chandrasena, Marco M. Gottardis, Weifang Shan, Jieping Geng, Aberra Fura, Joseph A. Furch, Cheryl A. Rizzo, Tom Mitt, Gregory D. Vite, Richard Rampulla
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1910-1915
A novel series of [2.2.1]-oxabicyclo imide-based compounds were identified as potent antagonists of the androgen receptor. Molecular modeling and iterative drug design were applied to optimize this series. The lead compound [3aS-(3aalpha,4beta,5beta,
Autor:
Mark E. Salvati, Yongmi An, Aaron Balog, Weifang Shan, Ricardo M. Attar, John S. Sack, Roberto Weinmann, Cheryl A. Rizzo, Jieping Geng, Kevin Kish, Donna D. Wei, Pickering Dacia A, Marco M. Gottardis, Stanley R. Krystek
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:271-276
A novel series of isoindoledione based compounds were identified as potent antagonists of the androgen receptor (AR). Co-crystallization of members of this family of inhibitors was successfully accomplished with the T877A AR LBD. A working model of h
Autor:
Marco M. Gottardis, Aaron Balog, Jieping Geng, Donna D. Wei, Pickering Dacia A, Ricardo M. Attar, Mark E. Salvati, John T. Hunt, Rogelio L. Martinez, Roberto Weinmann, Cheryl A. Rizzo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:389-393
A novel series of isoindoledione based compounds were identified as potent antagonists of the androgen receptor (AR). SAR around this series revealed dramatic differences in binding and function in mutant variants (MT) of the AR as compared to the wi