Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cheryl A. Johanns"'
Publikováno v:
Journal of Surgical Research. 76:179-184
Introduction. Muramlytripeptide phosphatidylethanolamine (MTP) stimulates synthesis of cytokines by hepatic Kupffer cells. We have shown in a perfused rat liver model that secondary ischemia/reperfusion (I/R) downregulates tumor necrosis factor alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fc551afe3ee17538855d17b4d3cd80
https://doi.org/10.1006/jsre.1998.5329
https://doi.org/10.1006/jsre.1998.5329
Autor:
Cheryl A. Johanns, Thomas F. Tracy, Andrew J. Lechner, Karl R. Knudsen, Alvaro Velasquez, George M. Matuschak
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 157:1550-1558
We employed a bile duct ligation (BDL) model of cholestatic liver injury to test the hypothesis that this form of preexisting hepatic dysfunction alters the kinetics of circulating TNF-alpha and IL-6 after Escherichia coli endotoxemia, thereby augmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688d2ea546f5cdc489f050761cc2cab5
https://doi.org/10.1164/ajrccm.157.5.9709067
https://doi.org/10.1164/ajrccm.157.5.9709067
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 157:629-637
Decreases in the alveolar O2 tension commonly follow gram-negative bacteremic shock that progresses to the acute respiratory distress syndrome (ARDS). To examine the effects of alveolar hypoxia and reoxygenation (H/R) on postbacteremic pulmonary cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb1d9c5a165c7c9f189b19fd5cdcb9f
https://doi.org/10.1164/ajrccm.157.2.9707120
https://doi.org/10.1164/ajrccm.157.2.9707120
Publikováno v:
Journal of Critical Care. 12:28-38
Purpose: During gram-negative bacteremia (GNB), tumor necrosis factor-α (TNF-α) is a critical early mediator of host defense, whose overexpression can initiate acute lung injury, multiple organ failure, and death. In this study we evaluated the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d30c97c2a1f74a1ffb6c6dabd3a745
https://doi.org/10.1016/s0883-9441(97)90023-x
https://doi.org/10.1016/s0883-9441(97)90023-x
Publikováno v:
Shock. 4:298-306
Cyclophosphamide-induced neutropenia exacerbates septic shock and multiple organ injury in conscious rats during Escherichia coli (EC) bacteremia despite antibiotics and fluid administration. We hypothesized that such shock and inflammatory organ inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d678b34d7daa45b5aeddd3d2b8cf531f
https://doi.org/10.1097/00024382-199510000-00012
https://doi.org/10.1097/00024382-199510000-00012
Publikováno v:
Journal of Biological Chemistry. 269:24994-24998
We have previously shown that the rat osteoblastic cell line UMR 106-01 responds to parathyroid hormone treatment by secreting interstitial collagenase. Secreted collagenase reaches a maximal concentration 12-24 h after parathyroid hormone stimulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::189f552865a1015e225c3f09f4f49eb4
https://doi.org/10.1016/s0021-9258(17)31488-6
https://doi.org/10.1016/s0021-9258(17)31488-6
Publikováno v:
American journal of respiratory and critical care medicine. 163(4)
We hypothesized that ischemia/reperfusion (I/R) injury of the liver during normotensive gram-negative bacteremic sepsis alters the kinetics of circulating endotoxin, tumor necrosis factor-alpha (TNF-alpha), and coinduced mediators, thereby exacerbati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f805d49f672bb0da1ec94903c81f34db
https://pubmed.ncbi.nlm.nih.gov/11282780
https://pubmed.ncbi.nlm.nih.gov/11282780
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 279(1)
Reductions in hepatic O2delivery are common early after gram-negative bacteremic sepsis owing to cardiopulmonary dysfunction and derangements in sinusoidal perfusion. Although gram-negative endotoxin and cellular hypoxia independently enhance activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6325c3fe46934f4037ec4ebe81e34f89
https://pubmed.ncbi.nlm.nih.gov/10896870
https://pubmed.ncbi.nlm.nih.gov/10896870
Publikováno v:
The American journal of physiology. 271(5 Pt 2)
Hepatic cytokine gene expression is independently stimulated by circulating microbial products and reductions in the cellular O2 supply. Although these stimuli occur sequentially after gram-negative bacteremia, it is unknown whether their interplay a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6dbd647943a2d96bd7a45795e53c3b2
https://pubmed.ncbi.nlm.nih.gov/8945969
https://pubmed.ncbi.nlm.nih.gov/8945969
Publikováno v:
The American journal of physiology. 270(1 Pt 2)
We tested the hypothesis that gram-negative bacteremia (GNB) and brief (30 min) reductions in the hepatic O2 supply by low-flow ischemia differentially modulate tumor necrosis factor-alpha (TNF-alpha) gene expression owing to sequence-specific activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144a641d67a4132410dc2d41548f180f
https://pubmed.ncbi.nlm.nih.gov/8769813
https://pubmed.ncbi.nlm.nih.gov/8769813