Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Cheryl A. Gregory"'
Levamisole derivatives as immune modulators for the treatment of amyotrophic lateral sclerosis (ALS)
Publikováno v:
Future Medicinal Chemistry. 15:651-659
Aim: To discover derivatives of the anthelmintic drug levamisole, which has been reported to possess immune-modulatory properties, as treatments for amyotrophic lateral sclerosis (ALS), which has been suggested to be in part an autoimmune disease. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4bf7b5da12772a87cb968b76da74d86
https://doi.org/10.4155/fmc-2023-0028
https://doi.org/10.4155/fmc-2023-0028
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 12, Pp 2050-2054 (2018)
Animal models are necessary to investigate the pathogenic features underlying motor neuron degeneration and for therapeutic development in amyotrophic lateral sclerosis (ALS). Measures of model validity allow for a critical interpretation of results
Externí odkaz:
https://doaj.org/article/dab163f1054e461ea5066d4a093a9702
Autor:
Xia Wang, Kevin Gregory-Evans, Kishor M. Wasan, Olena Sivak, Xianghong Shan, Cheryl Y. Gregory-Evans
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 417-428 (2017)
Nonsense mutations leading to premature stop codons are common occurring in approximately 12% of all human genetic diseases. Thus, pharmacological nonsense mutation suppression strategies would be beneficial to a large number of patients if the drugs
Externí odkaz:
https://doaj.org/article/a6ed6384546f4f6480f73742489fcc8c
Publikováno v:
Spectrums of Amyotrophic Lateral Sclerosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a019cecf7269b1c17f2f1e4032e82e4
https://doi.org/10.1002/9781119745532.ch3
https://doi.org/10.1002/9781119745532.ch3
Autor:
Ishaq A. Viringipurampeer, Kevin Gregory-Evans, Vahitha Shameem Nizamudheen, Anat Yanai, Cheryl Y. Gregory-Evans
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 15:556-566
Cell replacement therapy is emerging as an important approach in novel treatments for neurodegenerative diseases. Many problems remain, in particular improvements are needed in the survival of transplanted cells and increasing functional integration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a298add01ddfd2940ed06f1356216211
https://doi.org/10.1002/term.3193
https://doi.org/10.1002/term.3193
Autor:
Colin J. D. Ross, Xiaohua Han, Andrew D. Paterson, Casper Shyr, Care Rare Canada, Michelle Higginson, Victor Pegado, Cheryl Y. Gregory-Evans, Xin (Cynthia) Ye, Wyeth W. Wasserman, Nicole M. Roslin, Deborah Giaschi, Millan S. Patel, Oriol Fornes, Phillip A. Richmond, Christopher J. Lyons
Publikováno v:
Journal of Medical Genetics
Strabismus is a common condition, affecting 1-4% of individuals. Isolated strabismus has been studied in families with Mendelian inheritance patterns. Despite the identification of multiple loci via linkage analyses, no specific genes have been ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d51158113f2e14753f3fc0be0c4251
http://europepmc.org/articles/PMC8685624
http://europepmc.org/articles/PMC8685624
Publikováno v:
Precision Clinical Medicine. 3:113-126
Leber congenital amaurosis (LCA) is a severe, genetically heterogeneous recessive eye disease in which ~ 35% of gene mutations are in-frame nonsense mutations coding for loss-of-function premature termination codons (PTCs) in mRNA. Nonsense suppressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1af06bc9b0c68fb882d7beff6278805
https://doi.org/10.1093/pcmedi/pbaa009
https://doi.org/10.1093/pcmedi/pbaa009
Publikováno v:
Human Genetics. 138:865-880
Ocular coloboma is an uncommon, but often severe, sight-threatening condition that can be identified from birth. This congenital anomaly is thought to be caused by maldevelopment of optic fissure closure during early eye morphogenesis. It has been ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef361fe985405f082ae66dd64fce03b
https://doi.org/10.1007/s00439-019-02019-3
https://doi.org/10.1007/s00439-019-02019-3
Autor:
Peter Axerio-Cilies, Paul S. Rennie, Takeshi Yamazaki, Ari Kim, Miriam S. Butler, Sam Lawn, Michael E. Cox, Yubin Guo, Fariba Ghaidi, Scott Lien, Mannan Nouri, Marta Mroczek, Lawrence P. McIntosh, Cheryl Y. Gregory-Evans, Artem Cherkasov, Martin E. Gleave, Kush Dalal, Mani Roshan-Moniri, Desmond K. W. Lau, Paul M. Yen, Michael Hsing, Clement Yau
Publikováno v:
Oncotarget
// Miriam S. Butler 1, *, # , Mani Roshan-Moniri 1, *, # , Michael Hsing 1, *, # , Desmond Lau 2, *, # , Ari Kim 1 , Paul Yen 1 , Marta Mroczek 1 , Mannan Nouri 1 , Scott Lien 1 , Peter Axerio-Cilies 1 , Kush Dalal 1 , Clement Yau 1 , Fariba Ghaidi 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c1afad7acff7c115719c3c6e99761b
https://doi.org/10.18632/oncotarget.17124
https://doi.org/10.18632/oncotarget.17124
Autor:
Ishaq A. Viringipurampeer, Abu E. Bashar, Cheryl Y. Gregory-Evans, Orson L. Moritz, Kevin Gregory-Evans
Publikováno v:
International Journal of Inflammation, Vol 2013 (2013)
Genetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. Diverse genetic abnormalities and environmental causes
Externí odkaz:
https://doaj.org/article/630b48aac0fc4fc4872ae94b933bfc6a