Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Cheryl A London"'
Autor:
Katherine Dittrich, Ümmügülsüm Yıldız-Altay, Fatima Qutab, Danny A Kwong, Zechuan Rao, Sebastian A Nievez-Lozano, Heather L Gardner, Jillian M Richmond, Cheryl A London
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290428 (2023)
Pet dogs develop spontaneous diffuse large B cell lymphoma (DLBCL), and veterinary clinical trials have been employed to treat canine DLBCL and to inform clinical trials for their human companions. A challenge that remains is selection of treatment t
Externí odkaz:
https://doaj.org/article/c3e092a2d8ea4b18bd9e6af5fc3eab48
Autor:
Asma Boukhalfa, Sally R Robinson, Dawn M Meola, Nicholas A Robinson, Lauren A Ling, Joey N LaMastro, Jenica N Upshaw, Lakshmi Pulakat, Iris Z Jaffe, Cheryl A London, Howard H Chen, Vicky K Yang
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282859 (2023)
Chemotherapy-induced impairment of autophagy is implicated in cardiac toxicity induced by anti-cancer drugs. Imperfect translation from rodent models and lack of in vitro models of toxicity has limited investigation of autophagic flux dysregulation,
Externí odkaz:
https://doaj.org/article/5ea7be9f4e1b4e42ab80d1fbc2e93b4d
Autor:
Kate Megquier, Jason Turner-Maier, Kathleen Morrill, Xue Li, Jeremy Johnson, Elinor K Karlsson, Cheryl A London, Heather L Gardner
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274383 (2022)
The characterization of immortalized canine osteosarcoma (OS) cell lines used for research has historically been based on phenotypic features such as cellular morphology and expression of bone specific markers. With the increasing use of these cell l
Externí odkaz:
https://doaj.org/article/141e55c5532a44ba85cdda09c7b40708
Autor:
Heather L Gardner, Sarah B Rippy, Misty D Bear, Kim L Cronin, Heather Heeb, Holly Burr, Claire M Cannon, Kumar V Penmetsa, Srikant Viswanadha, Swaroop Vakkalanka, Cheryl A London
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195357 (2018)
RV1001 is a novel, potent, and selective PI3Kδ inhibitor. The purpose of this study was to evaluate the safety and efficacy of RV1001 in canine Non-Hodgkin lymphoma (NHL).Inhibition of endogenous pAKT by RV1001 in primary canine NHL cells was determ
Externí odkaz:
https://doaj.org/article/2cde8c7101d8458aaeb72cfb3d0632c4
Autor:
Cecilia M Lopez, Peter Y Yu, Xiaoli Zhang, Ayse Selen Yilmaz, Cheryl A London, Joelle M Fenger
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190086 (2018)
BACKGROUND:Osteosarcoma (OSA) is the most common bone tumor in children and dogs; however, no substantial improvement in clinical outcome has occurred in either species over the past 30 years. MicroRNAs (miRNAs) are small non-coding RNAs that regulat
Externí odkaz:
https://doaj.org/article/04fd16e280f043538235d7693eb5043c
Autor:
Peter Y Yu, Heather L Gardner, Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K LeBlanc, Hui Xiao, Jiayuh Lin, Denis C Guttridge, Xiaokui Mo, Chad E Bennett, Christopher C Coss, Yonghua Ling, Mitch A Phelps, Peter Houghton, Cheryl A London
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181885 (2017)
STAT3 is a transcription factor involved in cytokine and receptor kinase signal transduction that is aberrantly activated in a variety of sarcomas, promoting metastasis and chemotherapy resistance. The purpose of this work was to develop and test a n
Externí odkaz:
https://doaj.org/article/1e0e13539a7340a3a783709d729e834f
Autor:
Gretchen P. McLinden, Anne C. Avery, Heather L. Gardner, Kelly Hughes, Angie M. Rodday, Kexuan Liang, Cheryl A. London
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 38, Iss 3, Pp 1666-1674 (2024)
Abstract Background To explore the safety and utility of combining low dose single‐agent doxorubicin with a canine specific anti‐CD20 monoclonal antibody (1E4‐cIgGB) in client owned dogs with untreated B‐cell lymphoma. Animals Forty‐two cli
Externí odkaz:
https://doaj.org/article/298dea408eb844359dba10c2e4026ea5
Autor:
Bonnie K Harrington, Heather L Gardner, Raquel Izumi, Ahmed Hamdy, Wayne Rothbaum, Kevin R Coombes, Todd Covey, Allard Kaptein, Michael Gulrajani, Bart Van Lith, Cecile Krejsa, Christopher C Coss, Duncan S Russell, Xiaoli Zhang, Bridget K Urie, Cheryl A London, John C Byrd, Amy J Johnson, William C Kisseberth
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159607 (2016)
Acalabrutinib (ACP-196) is a second-generation inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK) with increased target selectivity and potency compared to ibrutinib. In this study, we evaluated acalabrutinib in spontaneously occurring cani
Externí odkaz:
https://doaj.org/article/885fb92964b3445a99b5a10f0adb8206
Autor:
Cheryl A London, Heather L Gardner, Tamra Mathie, Nicole Stingle, Roberta Portela, Michael L Pennell, Craig A Clifford, Mona P Rosenberg, David M Vail, Laurel E Williams, Kim L Cronin, Heather Wilson-Robles, Antonella Borgatti, Carolyn J Henry, Dennis B Bailey, Jennifer Locke, Nicole C Northrup, Martin Crawford-Jakubiak, Virginia L Gill, Mary K Klein, David M Ruslander, Doug H Thamm, Brenda Phillips, Gerald Post
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124889 (2015)
We hypothesized that the addition of toceranib to metronomic cyclophosphamide/piroxicam therapy would significantly improve disease-free interval (DFI) and overall survival (OS) in dogs with appendicular osteosarcoma (OSA) following amputation and ca
Externí odkaz:
https://doaj.org/article/a53bde96293544248c55b1e08df0a365
Autor:
Francisco Clemente-Vicario, Carlos E Alvarez, Jennie L Rowell, Satavisha Roy, Cheryl A London, William C Kisseberth, Gwendolen Lorch
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142007 (2015)
It has been an open question how similar human and canine lung cancers are. This has major implications in availability of human treatments for dogs and in establishing translational models to test new therapies in pet dogs. The prognosis for canine
Externí odkaz:
https://doaj.org/article/f0f529fdaa624040ba6d88e95acfae7c