Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Cheryl A Keller"'
Autor:
Cheryl A Keller, Alexander Q Wixom, Elisabeth F Heuston, Belinda Giardine, Chris C -S Hsiung, Maria R Long, Amber Miller, Stacie M Anderson, April Cockburn, Gerd A Blobel, David M Bodine, Ross C Hardison
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 6 (2021)
AbstractChromatin immunoprecipitation followed by massively parallel, high throughput sequencing (ChIP-seq) is the method of choice for genome-wide identification of DNA segments bound by specific transcription factors or in chromatin with particular
Externí odkaz:
https://doaj.org/article/187ad77994884baf9b47056148b28010
Autor:
Guanjue Xiang, Belinda Giardine, Lin An, Chen Sun, Cheryl A. Keller, Elisabeth F. Heuston, Stacie M. Anderson, Martha Kirby, David Bodine, Yu Zhang, Ross C. Hardison
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Epigenetic modification of chromatin plays a pivotal role in regulating gene expression during cell differentiation. The scale and complexity of epigenetic data pose significant challenges for biologists to identify the regulatory
Externí odkaz:
https://doaj.org/article/5ffe37119b794e6e9a7d5b9bec15d47b
Autor:
Elisabeth F. Heuston, Cheryl A. Keller, Jens Lichtenberg, Belinda Giardine, Stacie M. Anderson, NIH Intramural Sequencing Center, Ross C. Hardison, David M. Bodine
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-18 (2018)
Abstract Background Enhancers and promoters are cis-acting regulatory elements associated with lineage-specific gene expression. Previous studies showed that different categories of active regulatory elements are in regions of open chromatin, and eac
Externí odkaz:
https://doaj.org/article/ffa0091b021042a59e44f4d492feec23
Autor:
Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo-Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 400-415.e5 (2019)
Summary: Global changes in chromatin organization and the cessation of transcription during mitosis are thought to challenge the resumption of appropriate transcription patterns after mitosis. The acetyl-lysine binding protein BRD4 has been previousl
Externí odkaz:
https://doaj.org/article/8b145c50765d4778bd5ce4df11b251aa
Autor:
Guanjue Xiang, Xi He, Belinda M. Giardine, Kathryn J. Weaver, Dylan J. Taylor, Rajiv C. McCoy, Camden Jansen, Cheryl A. Keller, Alexander Q. Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, Elisabeth F. Heuston, Stacie M. Anderson, Jing Luan, Marit W. Vermunt, Feng Yue, Michael E.G. Sauria, Michael C. Schatz, James Taylor, Berthold Göttgens, Jim R. Hughes, Douglas R. Higgs, Mitchell J. Weiss, Yong Cheng, Gerd A. Blobel, David Bodine, Yu Zhang, Qunhua Li, Shaun Mahony, Ross C. Hardison
Knowledge of locations and activities ofcis-regulatory elements (CREs) is needed to decipher basic mechanisms of gene regulation and to understand the impact of genetic variants on complex traits. Previous studies identified candidate CREs (cCREs) us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef37c806f6c18c3930749db34dc396f5
https://doi.org/10.1101/2023.04.02.535219
https://doi.org/10.1101/2023.04.02.535219
Autor:
Kunhua Qin, Xianjiang Lan, Peng Huang, Megan S. Saari, Eugene Khandros, Cheryl A Keller, Belinda M. Giardine, Osheiza Abdulmalik, Junwei Shi, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Blood.
The fetal (HbF)-to-adult (HbA) hemoglobin switch is a paradigm for developmental gene expression control with relevance to sickle cell disease and b-thalassemia. Polycomb repressive complex (PRC) proteins regulate this switch, and an inhibitor of PRC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2836ffab659abb0f4353fd99a0d730d4
https://doi.org/10.1182/blood.2022019578
https://doi.org/10.1182/blood.2022019578
Autor:
Kunhua Qin, Peng Huang, Ruopeng Feng, Cheryl A. Keller, Scott A. Peslak, Eugene Khandros, Megan S. Saari, Xianjiang Lan, Thiyagaraj Mayuranathan, Phillip A. Doerfler, Osheiza Abdulmalik, Belinda Giardine, Stella T. Chou, Junwei Shi, Ross C. Hardison, Mitchell J. Weiss, Gerd A. Blobel
Publikováno v:
Nature Genetics. 54:874-884
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d01ccfde1bb041df2c3ef2817959b04a
https://doi.org/10.1038/s41588-022-01076-1
https://doi.org/10.1038/s41588-022-01076-1
Autor:
Jing Luan, Marit W. Vermunt, Camille M. Syrett, Allison Coté, Jacob M. Tome, Haoyue Zhang, Anran Huang, Jennifer M. Luppino, Cheryl A. Keller, Belinda M. Giardine, Shiping Zhang, Margaret C. Dunagin, Zhe Zhang, Eric F. Joyce, John T. Lis, Arjun Raj, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Nat Struct Mol Biol
Transcription at most promoters is divergent, initiating at closely spaced oppositely oriented core promoters to produce sense transcripts along with often unstable upstream antisense transcripts (uasTrx). How antisense transcription is regulated and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875560af4f05b41231d06865134f4090
https://europepmc.org/articles/PMC10015438/
https://europepmc.org/articles/PMC10015438/
Autor:
Peng Huang, Scott A. Peslak, Ren Ren, Eugene Khandros, Kunhua Qin, Cheryl A. Keller, Belinda Giardine, Henry W. Bell, Xianjiang Lan, Malini Sharma, John R. Horton, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Merlin Crossley, Ross C. Hardison, Xiaodong Cheng, Gerd A. Blobel
Publikováno v:
Nat Genet
The fetal-to-adult switch in hemoglobin production is a model of developmental gene control with relevance to the treatment of hemoglobinopathies. The expression of transcription factor BCL11A, which represses fetal β-type globin (HBG) genes in adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b27f4d476434f6a5f7d6ba96595d359
https://europepmc.org/articles/PMC9940634/
https://europepmc.org/articles/PMC9940634/
Autor:
Cait E. Hamele, Mariella F. Toro, Emily Farber, Jeffrey C. Xing, Cheryl A. Keller, Kristine C. Olson, Umadevi Paila, Suna Onengut-Gumuscu, Thomas L. Olson, Thomas P. Loughran, Aakrosh Ratan, Yaseswini Neelamraju, Shriram K. Sundararaman, Matt Schmachtenberg, Hee Jin Cheon, David J. Feith, Ross C. Hardison, Bryna C. Shemo, Francine E. Garrett-Bakelman
Publikováno v:
Blood
Chronic natural killer large granular lymphocyte (NK-LGL) leukemia, also referred to as chronic lymphoproliferative disorder of NK cells, is a rare disorder defined by prolonged expansion of clonal NK cells. Similar prevalence of STAT3 mutations in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c664dfbeb97b115047b780f175a174
https://doi.org/10.1182/blood.2020005831
https://doi.org/10.1182/blood.2020005831