Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Cheryl A Janson"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 4, p e0011303 (2023)
Lymphatic filariasis is a debilitating illness with an estimated 50 million cases as of 2018. The majority of cases are caused by the parasitic worm W. bancrofti and additional cases by the worms B. malayi and B. timori. Dihydrofolate reductase (DHFR
Externí odkaz:
https://doaj.org/article/8c20d36c91bc4e7eb05fa27a07735415
Autor:
Andrew M Tobias, Dea Toska, Keith Lange, Tyler Eck, Rohit Bhat, Cheryl A Janson, David P Rotella, Ueli Gubler, Nina M Goodey
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197173 (2018)
Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR
Externí odkaz:
https://doaj.org/article/2c8a0df7e2ef4f8b811d5074508981ba
Autor:
Ueli Gubler, Uththara Liyanagunawardana, Thomas Candela, Nina M. Goodey, Jaclyn Catalano, Natalia E. Reis, Michael Little, Katherine Leon H, Tyler Eck, Seema Patel, Cheryl A. Janson
Publikováno v:
Archives of Biochemistry and Biophysics. 692:108545
Many antibacterial and antiparasitic drugs work by competitively inhibiting dihydrofolate reductase (DHFR), a vital enzyme in folate metabolism. The interactions between inhibitors and DHFR active site residues are known in many homologs but the cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61db613d9fcc1c9615dcc2be853fab33
https://doi.org/10.1016/j.abb.2020.108545
https://doi.org/10.1016/j.abb.2020.108545
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bba177e9e4d07038b4cdb65171b61fa9
https://doi.org/10.1096/fasebj.2018.32.1_supplement.674.18
https://doi.org/10.1096/fasebj.2018.32.1_supplement.674.18
Autor:
Cheryl A. Janson, Keith Richard Lange, Dea Toska, Andrew M. Tobias, David P. Rotella, Nina M. Goodey, Tyler Eck, Rohit Bhat, Ueli Gubler
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197173 (2018)
PLoS ONE
PLoS ONE
Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2d3b020a513a1767eb5a22314de81e
http://europepmc.org/articles/PMC5963757?pdf=render
http://europepmc.org/articles/PMC5963757?pdf=render
Autor:
Xiayang Qiu, Sherin S. Abdel-Meguid, Robert I. Court, Cheryl A. Janson, David J. Payne, Martin G. Smyth
Publikováno v:
Protein Science. 8:2529-2532
The crystal structure of the Escherichia coli enoyl reductase-NAD+-triclosan complex has been determined at 2.5 A resolution. The Ile192-Ser198 loop is either disordered or in an open conformation in the previously reported structures of the enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1397dc8135b5a84d46397b15ab79eb6
https://doi.org/10.1110/ps.8.11.2529
https://doi.org/10.1110/ps.8.11.2529
Autor:
Xiayang Qiu, Cheryl A. Janson
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 60:1545-1554
A topic of current interest is engineering surface mutations in order to improve the success rate of protein crystallization. This report explores the possibility of using metal-ion-mediated crystal-packing interactions to facilitate rational design.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4b3f1a12dfd05f8c5e51b591668083
https://doi.org/10.1107/s0907444904015422
https://doi.org/10.1107/s0907444904015422
Autor:
Martin Brandt, Robert A. Daines, Israil Pendrak, Glenn S. Van Aller, Martha S. Head, Kelvin Sham, Xiayang Qiu, Sanjay S. Khandekar, Carol Silverman, Alex K. Konstantinidis, Cheryl A. Janson, John T. Lonsdale
Publikováno v:
Journal of Medicinal Chemistry. 46:5-8
The first cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor is reported. The inhibitor was obtained by rational modification of a high throughput screening lead with the aid of a S. pneumoniae FabH homology mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b3298898c706796fb7eeb5a0076895
https://doi.org/10.1021/jm025571b
https://doi.org/10.1021/jm025571b
Autor:
William H. Miller, Catherine C.K. Yuan, Kalindi Vaidya, Brian J. Polizzi, Dennis T. Takata, Rebecca Claire Greenwood, Dirk A. Heerding, Mark A. Seefeld, Scott B. Winram, Valerie Berry, Martha S. Head, Walter J. Burgess, Andrew P. Fosberry, Nicola G. Wallis, David J. Payne, Stephen Rittenhouse, William F. Huffman, Paul M. Keller, Kevin L. Salyers, Manley Peter J, Kenneth A. Newlander, Deborah Dee Jaworski, Courtney Slater-Radosti, Cheryl A. Janson, Walter E. DeWolf, Irene N. Uzinskas, John Brosky, Stewart C. Pearson, Xiayang Qiu, Emile Chen, Terrance D. Moore, Martin G. Smyth
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:3118-3124
Bacterial enoyl-acyl carrier protein (ACP) reductase (FabI) catalyzes the final step in each elongation cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. High-throughput screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997a68e3d46cb5b0dd9196003827969e
https://doi.org/10.1128/aac.46.10.3118-3124.2002
https://doi.org/10.1128/aac.46.10.3118-3124.2002
Autor:
William F. Huffman, Paul M. Keller, Valerie Berry, Walter E. DeWolf, William H. Miller, Catherine C.K. Yuan, Mark A. Seefeld, Stephen Rittenhouse, Brian J. Polizzi, Stewart C. Pearson, Cheryl A. Janson, Dirk A. Heerding, Walter J. Burgess, Martha S. Head, Terrance D. Moore, Kenneth A. Newlander, Xiayang Qiu, Irene N. Uzinskas, David J. Payne
Publikováno v:
Journal of Medicinal Chemistry. 45:3246-3256
Bacterial enoyl-ACP reductase (FabI) catalyzes the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. Our eff...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac5be10717eef2aed6ee5bf83df2f1ef
https://doi.org/10.1021/jm020050+
https://doi.org/10.1021/jm020050+