Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients.

Autor: Liesbeth Bieghs, Malene Brohus, Ida B Kristensen, Niels Abildgaard, Martin Bøgsted, Hans E Johnsen, Cheryl A Conover, Elke De Bruyne, Karin Vanderkerken, Michael T Overgaard, Mette Nyegaard

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0154256 (2016)

Insulin-like growth factor (IGF) signalling plays a key role in homing, progression, and treatment resistance in multiple myeloma (MM). In the extracellular environment, the majority of IGF molecules are bound to one of six IGF-binding proteins (IGFB

Externí odkaz: https://doaj.org/article/1ec7239160444eb891a0a754cbf06314

Senescence induces proteolytically-active PAPP-A secretion and association with extracellular vesicles in human pre-adipocytes

Autor: Cheryl A. Conover, Laurie K. Bale

Publikováno v: Experimental Gerontology, Vol 172, Iss , Pp 112070- (2023)

Senescence is a cellular response to various stressors characterized by irreversible cell cycle arrest, resistance to apoptosis and expression of a senescence-associated secretory phenotype (SASP). Interestingly, studies where senescent cells were de

Externí odkaz: https://doaj.org/article/df79a39808f543338c05d9fcde713ab1

Legend for Supplemental Figure 1 from A Novel Neutralizing Antibody Targeting Pregnancy-Associated Plasma Protein-A Inhibits Ovarian Cancer Growth and Ascites Accumulation in Patient Mouse Tumorgrafts

Autor: Cheryl A. Conover, Claus Oxvig, Laurie K. Bale, Paul Haluska, Marc A. Becker

Legend for Supplemental Figure 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3287563bb74956824d650aa4f6b2ef01
https://doi.org/10.1158/1535-7163.22500111

The Stanniocalcin-PAPP-A-IGFBP-IGF Axis

Autor: Claus Oxvig, Cheryl A Conover

Publikováno v: The Journal of Clinical Endocrinology & Metabolism.

The pappalysin metalloproteinases, PAPP-A and PAPP-A2, have emerged as highly specific proteolytic enzymes involved in the regulation of insulin-like growth factor (IGF) signaling. The only known pappalysin substrates are a subset of the IGF binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::023c642c6d3da2c730149826db781488
https://doi.org/10.1210/clinem/dgad053

Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability

Autor: Anne Mette Frøbert, Malene Brohus, Tinna S. Roesen, Jonas Kindberg, Ole Fröbert, Cheryl A. Conover, Michael T. Overgaard

Publikováno v: Frøbert, A M, Brohus, M, Roesen, T S, Kindberg, J, Fröbert, O, Conover, C A & Overgaard, M T 2022, ' Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability ', American Journal of Physiology-Endocrinology and Metabolism, vol. 323, no. 3, pp. E307-E318 . https://doi.org/10.1152/ajpendo.00429.2021
Frøbert, A M, Brohus, M, Roesen, T S, Kindberg, J, Fröbert, O, Conover, C A & Overgaard, M T 2022, ' Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability ', American Journal of Physiology: Endocrinology and Metabolism, vol. 323, no. 3, pp. E307-E318 . https://doi.org/10.1152/ajpendo.00429.2021

Brown bears conserve muscle and bone mass during 6 mo of inactive hibernation. The molecular mechanisms underlying hibernation physiology may have translational relevance for human therapeutics. We hypothesize that protective mechanisms involve incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b57d1594d1d384c49a2a5c357e2840f
https://pure.au.dk/portal/da/publications/circulating-insulinlike-growth-factor-system-adaptations-in-hibernating-brown-bears-indicate-increased-tissue-igf-availability(7ab93ef1-880c-49f0-aba1-c2d20bf72ce7).html