Mutations in pregnancy‐associated plasma protein A2 cause short stature due to low IGF‐I availability

Autor: Andrew Dauber, María T Muñoz‐Calvo, Vicente Barrios, Horacio M Domené, Soren Kloverpris, Clara Serra‐Juhé, Vardhini Desikan, Jesús Pozo, Radhika Muzumdar, Gabriel Á Martos‐Moreno, Federico Hawkins, Héctor G Jasper, Cheryl A Conover, Jan Frystyk, Shoshana Yakar, Vivian Hwa, Julie A Chowen, Claus Oxvig, Ron G Rosenfeld, Luis A Pérez‐Jurado, Jesús Argente

Publikováno v: EMBO Molecular Medicine, Vol 8, Iss 4, Pp 363-374 (2016)

Abstract Mutations in multiple genes of the growth hormone/IGF‐I axis have been identified in syndromes marked by growth failure. However, no pathogenic human mutations have been reported in the six high‐affinity IGF‐binding proteins (IGFBPs) o

Externí odkaz: https://doaj.org/article/224828b64cec4bdd98548afe1c5d47d5

The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.

Autor: Malene Brohus, Vera Gorbunova, Chris G Faulkes, Michael T Overgaard, Cheryl A Conover

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145587 (2015)

Naked mole-rats (Heterocephalus glaber) (NMRs) are the longest living rodents known. They show negligible senescence, and are resistant to cancers and certain damaging effects associated with aging. The insulin-like growth factors (IGFs) have pluripo

Externí odkaz: https://doaj.org/article/f270fa029f934c61820b7b2667edcd10

Legend for Supplemental Figure 1 from A Novel Neutralizing Antibody Targeting Pregnancy-Associated Plasma Protein-A Inhibits Ovarian Cancer Growth and Ascites Accumulation in Patient Mouse Tumorgrafts

Autor: Cheryl A. Conover, Claus Oxvig, Laurie K. Bale, Paul Haluska, Marc A. Becker

Legend for Supplemental Figure 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3287563bb74956824d650aa4f6b2ef01
https://doi.org/10.1158/1535-7163.22500111

The Stanniocalcin-PAPP-A-IGFBP-IGF Axis

Autor: Claus Oxvig, Cheryl A Conover

Publikováno v: The Journal of Clinical Endocrinology & Metabolism.

The pappalysin metalloproteinases, PAPP-A and PAPP-A2, have emerged as highly specific proteolytic enzymes involved in the regulation of insulin-like growth factor (IGF) signaling. The only known pappalysin substrates are a subset of the IGF binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::023c642c6d3da2c730149826db781488
https://doi.org/10.1210/clinem/dgad053

Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability

Autor: Anne Mette Frøbert, Malene Brohus, Tinna S. Roesen, Jonas Kindberg, Ole Fröbert, Cheryl A. Conover, Michael T. Overgaard

Publikováno v: Frøbert, A M, Brohus, M, Roesen, T S, Kindberg, J, Fröbert, O, Conover, C A & Overgaard, M T 2022, ' Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability ', American Journal of Physiology-Endocrinology and Metabolism, vol. 323, no. 3, pp. E307-E318 . https://doi.org/10.1152/ajpendo.00429.2021
Frøbert, A M, Brohus, M, Roesen, T S, Kindberg, J, Fröbert, O, Conover, C A & Overgaard, M T 2022, ' Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability ', American Journal of Physiology: Endocrinology and Metabolism, vol. 323, no. 3, pp. E307-E318 . https://doi.org/10.1152/ajpendo.00429.2021

Brown bears conserve muscle and bone mass during 6 mo of inactive hibernation. The molecular mechanisms underlying hibernation physiology may have translational relevance for human therapeutics. We hypothesize that protective mechanisms involve incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b57d1594d1d384c49a2a5c357e2840f
https://pure.au.dk/portal/da/publications/circulating-insulinlike-growth-factor-system-adaptations-in-hibernating-brown-bears-indicate-increased-tissue-igf-availability(7ab93ef1-880c-49f0-aba1-c2d20bf72ce7).html