Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis

Autor: Fenghua Zhang, Ehab A Ayaub, Bingbing Wang, Estela Puchulu‐Campanella, Yen‐Hsing Li, Suraj U Hettiarachchi, Spencer D Lindeman, Qian Luo, Sasmita Rout, Madduri Srinivasarao, Abigail Cox, Konstantin Tsoyi, Cheryl Nickerson‐Nutter, Ivan O Rosas, Philip S Low

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 8, Pp 1-15 (2020)

Abstract Fibrotic diseases cause organ failure that lead to ~45% of all deaths in the United States. Activated macrophages stimulate fibrosis by secreting cytokines that induce fibroblasts to synthesize collagen and extracellular matrix proteins. Alt

Externí odkaz: https://doaj.org/article/6c2ab7c60e9040ec977bb024e8f6c67b

Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy

Autor: Allison G. Roy, J. Michael Robinson, Prannda Sharma, Alba Rodriguez-Garcia, Mathilde A. Poussin, Cheryl Nickerson-Nutter, Daniel J. Powell

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11, p 5572 (2021)

Folate receptor beta (FRβ) is a folate binding receptor expressed on myeloid lineage hematopoietic cells. FRβ is commonly expressed at high levels on malignant blasts in patients with acute myeloid leukemia (AML), as well as on M2 polarized tumor-a

Externí odkaz: https://doaj.org/article/f4b572fb1bb944a9ac765596845a7de5

Selective Reprogramming of Pulmonary Macrophages for Treatment of Pulmonary Fibrosis

Autor: Ivan O. Rosas, Konstantin Tsoyi, Spencer D. Lindeman, Bingbing Wang, Abigail Cox, Fenghua Zhang, Suraj U. Hettiarachchi, Estela Puchulu-Campanella, Cheryl Nickerson-Nutter, Philip S. Low, Madduri Srinivasarao, Ehab A. Ayaub, Yen-Hsing Li, S. Rout

Publikováno v: D109. MODULATING THE FIBROTIC RESPONSE.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a89b9a9be32abbd76f25622ee89a6bc
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7872

Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

Autor: Stewart A. Low, Bingbing Wang, Eric L. Matteson, Philip S. Low, Karson S. Putt, Clemens Ruppert, Yingwen Hu, Jiayin Shen, Hans W.M. Niessen, Cheryl Nickerson-Nutter, Dimiter S. Dimitrov, Gerrit Jansen, Linda M. Murphy, Stephen J. Oliver, Yang Feng

Publikováno v: Arthritis Research and Therapy, 21(1):143. BioMed Central
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)
Arthritis Research & Therapy
Hu, Y, Wang, B, Shen, J, Low, S A, Putt, K S, Niessen, H W M, Matteson, E L, Murphy, L, Ruppert, C, Jansen, G, Oliver, S J, Feng, Y, Dimitrov, D S, Nickerson-Nutter, C & Low, P S 2019, ' Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis ', Arthritis Research and Therapy, vol. 21, no. 1, 143 . https://doi.org/10.1186/s13075-019-1912-0

Objectives Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF). However, no approved therapies directly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86fea1408cd68a951029848818adc44
https://research.vumc.nl/en/publications/933709e3-08d8-4dcf-9eaa-7b43c4769024

Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy

Autor: Mathilde Poussin, Cheryl Nickerson-Nutter, Daniel J. Powell, Prannda Sharma, J. Michael Robinson, Alba Rodriguez-Garcia, A.G. Roy

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 11; Pages: 5572
International Journal of Molecular Sciences, Vol 22, Iss 5572, p 5572 (2021)
International Journal of Molecular Sciences

Folate receptor beta (FRβ) is a folate binding receptor expressed on myeloid lineage hematopoietic cells. FRβ is commonly expressed at high levels on malignant blasts in patients with acute myeloid leukemia (AML), as well as on M2 polarized tumor-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed656f20f6a67a1f67a39c224be4013
https://doi.org/10.3390/ijms22115572