Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cheryl A. Mugford"'
Autor:
Casey Cameron Mccomas, Jenifer A. Bray, Cheryl A. Mugford, Puwen Zhang, Terefenko Eugene Anthony, Eugene John Trybulski, An T. Vu, Andrew Fensome, Garth T. Whiteside, Elizabeth Koury, Lilly Mark, Jim Harrison, Darlene C. Deecher, Paige Erin Mahaney, Kim Callain Younghee
Publikováno v:
Journal of Medicinal Chemistry. 52:5703-5711
Sequential structural modifications of the aryloxypropanamine template (e.g., atomoxetine, 2) led to a novel series of 1-(3-amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors (NRIs). In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc387e88a81026305a6f4d591b56022
https://doi.org/10.1021/jm900888c
https://doi.org/10.1021/jm900888c
Autor:
Jennifer Leiter, An T. Vu, Yingru Zhang, Sharon Rosenzweig-Lipson, Fei Ye, Valerie Smith, Stephen Todd Cohn, Douglas M. Ho, Elizabeth Koury, Justin K. Belardi, Darlene C. Deecher, Cheryl A. Mugford, Grace H. Johnston, Gary Paul Stack, Kevin D. Burroughs, Eugene John Trybulski, Scott Cosmi, Jenifer A. Bray, Joseph Peter Sabatucci, Lori Krim Gavrin, Liza Leventhal, Paige Erin Mahaney, Brian J. Platt, Arthur A. Santilli
Publikováno v:
Journal of Medicinal Chemistry. 51:4038-4049
Further exploration of the cycloalkanol ethylamine scaffold, of which venlafaxine ( 1) is a member, was undertaken to develop novel and selective norepinephrine reuptake inhibitors (NRIs) for evaluation in a variety of predictive animal models. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1714c4c78e768fe2426cceb434cdd1c4
https://doi.org/10.1021/jm8002262
https://doi.org/10.1021/jm8002262
Autor:
Joan B. Tarloff, Cheryl A. Mugford
Publikováno v:
Toxicology Letters. 93:15-22
Young adult female rats are more susceptible to acetaminophen (APAP) induced nephrotoxicity than are male rats. The purpose of the present study was to assess the contribution of oxidation and deacetylation to the expression of APAP nephrotoxicity. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143bc5ecd06d9182198c0a992fe15508
https://doi.org/10.1016/s0378-4274(97)00063-5
https://doi.org/10.1016/s0378-4274(97)00063-5
Autor:
Jennifer Leiter, Kevin D. Burroughs, Eugene John Trybulski, Douglas John Jenkins, Grace H. Johnston, Darlene C. Deecher, Jenifer A. Bray, Lori Krim Gavrin, Douglas M. Ho, Lisa Nogle, Christine Huselton, Paige Erin Mahaney, Scott Cosmi, Peter D. Alfinito, Cheryl A. Mugford
The potency and selectivity of a series of 1-{(1S)-2-[amino]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol analogues are described. These compounds were prepared to improve in vitro metabolic stability and achieve brain penetration. Compound 13 (W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc6d55b4dfa0db0768f818af67c34ee
https://europepmc.org/articles/PMC4007968/
https://europepmc.org/articles/PMC4007968/
Publikováno v:
Fundamental and Applied Toxicology. 19:43-49
1-Aminobenzotriazole (ABT) is a suicide substrate of both hepatic and pulmonary cytochromes P450. The present studies were designed to compare the effects of ABT on hepatic and renal metabolism. Hepatic and renal microsomes and cytosol were prepared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec0ce935a82ba4257a4f494c07e9cf0
https://doi.org/10.1016/0272-0590(92)90026-e
https://doi.org/10.1016/0272-0590(92)90026-e
Autor:
Reinhardt Bernhard Baudy, Boyd L. Harrison, Jean Y. Sze, Menelas N. Pangalos, Jeffrey D. Kennedy, Michael R. Brandt, Michael May, Terri Cummons, Ronald L. Magolda, Wayne E. Childers, Uday Jain, John A. Butera, Matthew Hoffmann, Hong Chen, Diane Kowal, Bojana Zupan, Magid Abou-Gharbia, Cheryl P. Mugford
Publikováno v:
Journal of medicinal chemistry. 52(3)
Previous studies with perzinfotel (1), a potent, selective, competitive NMDA receptor antagonist, showed it to be efficacious in inflammatory and neuropathic pain models. To increase the low oral bioavailability of 1 (3−5%), prodrug derivatives (3a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc47d6ea6774cab53f633c680537098
https://pubmed.ncbi.nlm.nih.gov/19146418
https://pubmed.ncbi.nlm.nih.gov/19146418
Autor:
Valerie Hudak, Zhiming Zhang, Yuan Zhu, Cheryl A. Mugford, Michael A. Marella, Thomas J. Berrodin, Kern Jeffrey Curtis, William R. Adams, Edward George Melenski, Matthew Yudt, Jeff Cohen, Richard C. Winneker, Ov D. Slayden, Andrea L. Adams, Andrew Fensome, Jay E. Wrobel, Puwen Zhang, Casey C. McComas, Arthur Illenberger, Christine Huselton
Publikováno v:
Journal of medicinal chemistry. 51(6)
We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previously we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a88b9a7f70913367d05174fd7d26e9c
https://pubmed.ncbi.nlm.nih.gov/18318463
https://pubmed.ncbi.nlm.nih.gov/18318463
Autor:
Girija Krishnamurthy, David L. Crandall, Hassan Mahmoud Elokdah, Geraldine Ruth Mcfarlane, Cheryl P. Mugford, James Hennan, Magid Abou-Gharbia
Publikováno v:
ChemInform. 35
Indole oxoacetic acid derivatives were prepared and evaluated for in vitro binding to and inactivation of human plasminogen activator inhibitor-1 (PAI-1). SAR based on biochemical, physiological, and pharmacokinetic attributes led to identification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4440dfe10c7270a591fdfcb514afcc40
https://doi.org/10.1002/chin.200442134
https://doi.org/10.1002/chin.200442134
Publikováno v:
Toxicology and applied pharmacology. 144(1)
Furan is a potent rodent hepatotoxicant and carcinogen. The present study was done to examine the effects of furan on hepatic energy metabolism both in vivo and in vitro in male F-344 rats. Furan produced concentration- and incubation time-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4dd6eb2c8bdb8caa07d061eb873fe1
https://pubmed.ncbi.nlm.nih.gov/9169064
https://pubmed.ncbi.nlm.nih.gov/9169064
Autor:
Puwen Zhang, Eugene A. Terefenko, Jenifer Bray, Darlene Deecher, Andrew Fensome, Jim Harrison, Callain Kim, Elizabeth Koury, Lilly Mark, Casey C. McComas, Cheryl A. Mugford, Eugene J. Trybulski, An T. Vu, Garth T. Whiteside, Paige E. Mahaney
Publikováno v:
Journal of Medicinal Chemistry; Sep2009, Vol. 52 Issue 18, p5703-5711, 9p