Výsledky vyhledávání - "Chery A. Whipple"

Akademický článek

Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis

Autor: Chery A. Whipple, Arthur D. Lander, Murray Korc

Publikováno v: The Scientific World Journal, Vol 8, Pp 1250-1253 (2008)

The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-der

Externí odkaz: https://doaj.org/article/86648448a7e34ac594a0a1aa7e53dde6

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Immune modulation associated with vascular endothelial growth factor (VEGF) blockade in patients with glioblastoma

Autor: Brock C. Christensen, Alissa A. Thomas, Arti B. Gaur, Marc S. Ernstoff, Gilbert J. Rahme, Camilo E. Fadul, Sandra E. Steel, Chery A. Whipple, Melissa C. Davis, Thomas H. Hampton, Jan L. Fisher, Lionel D. Lewis, Gregory J. Tsongalis

Publikováno v: Cancer Immunology, Immunotherapy. 66:379-389

Vascular endothelial growth factor (VEGF), in addition to being pro-angiogenic, is an immunomodulatory cytokine systemically and in the tumor microenvironment. We previously reported the immunomodulatory effects of radiation and temozolomide (TMZ) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b070b7350d57896ce7c2af20a30602
https://doi.org/10.1007/s00262-016-1941-3

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Regulatory T cells are not a strong predictor of survival for patients with glioblastoma

Autor: Alissa A. Thomas, Jan L. Fisher, Francine B. de Abreu, Michael B. Miller, C. Harker Rhodes, Joel A. Lefferts, Gilbert J. Rahme, Thomas H. Hampton, Chery A. Whipple, Camilo E. Fadul, Laura J. Tafe, Jonathan K. Kleen, Gregory J. Tsongalis, Heather A. Wishart, Tim Schwachula, Sven Olek, Marc S. Ernstoff, Udo Baron, Jiang Gui

Publikováno v: Neuro-Oncology. 17:801-809

Immunotherapy is emerging as an effective new treatment for many cancers,1 but it has yet to translate into a proven clinical benefit for patients with glioblastoma.2 A purported limitation of applying immunotherapy to gliomas is the tumor-induced im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e02d676f60988d813dfb066700bf2a3
https://doi.org/10.1093/neuonc/nou363

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The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells

Autor: Diane Mellinger, Laura J. Tafe, Jan L. Fisher, Gregory J. Tsongalis, Marc S. Ernstoff, Thomas H. Hampton, Camilo E. Fadul, Andrea Boni, Shaofeng Yan, Chery A. Whipple, Mary Jo Turk, David W. Mullins, Constance E. Brinckerhoff

Publikováno v: Melanoma research. 26(3)

The advent of drugs targeting the mitogen-activated protein kinase (MAPK) pathway has markedly changed the treatment of advanced-stage melanoma harboring BRAF mutations. However, drug resistance, through mechanisms not well elucidated, often occurs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973eb019e4ff190bda5c8e7d1d39f571
https://pubmed.ncbi.nlm.nih.gov/26974965

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Targeting angiogenesis in pancreatic cancer: rationale and pitfalls

Autor: Chery A. Whipple, Murray Korc

Publikováno v: Langenbeck's Archives of Surgery. 393:901-910

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer responsible for over 20% of deaths due to gastrointestinal malignancies. PDAC is usually diagnosed at an advanced stage which, in part, helps to explain its high resistance to chem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398c432d25137df0410b25fe94b8614a
https://doi.org/10.1007/s00423-008-0280-z

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Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells

Autor: Jason R. Gunn, Chery A. Whipple, Murray Korc, Martha E. Lopez, Alison L. Young, Takuma Aikawa, Arthur D. Lander

Publikováno v: Aikawa, T; Whipple, CA; Lopez, ME; Gunn, J; Young, A; Lander, AD; et al.(2008). Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells. Journal of Clinical Investigation, 118(1), 89-99. doi: 10.1172/JCI32412. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2n50291v

Cells isolated from many types of human cancers express heparin-binding growth factors (HBGFs) that drive tumor growth, metastasis, and angiogenesis. The heparan sulfate proteoglycan glypican-1 (GPC1) is a coreceptor for HBGFs. Here we show that both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dc346cd2aaeba154404e0aa074d407
https://doi.org/10.1172/jci32412

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Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis

Autor: Murray Korc, Chery A. Whipple, Arthur D. Lander

Publikováno v: The Scientific World Journal, Vol 8, Pp 1250-1253 (2008)
Whipple, Chery A; Lander, Arthur D; & Korc, Murray. (2008). Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis. The Scientific World JOURNAL, 8, 1250-1253. doi: 10.1100/tsw.2008.152. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0nt6161n
The Scientific World Journal

The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cellsin vivoand markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3331cd37c79f422c38458430c2e87cf6
https://doaj.org/article/86648448a7e34ac594a0a1aa7e53dde6

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Tumor talk: understanding the conversation between the tumor and its microenvironment

Autor: Chery A. Whipple

Publikováno v: Cancer Cell & Microenvironment.

It was once believed that tumor growth, progression, and metastasis were intrinsically driven by the tumor. Instead, recent research has demonstrated that a solid tumor is surrounded by a complex matrix of cells, particularly fibroblasts, which suppo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7039716a12ba67cae5712f317a75947c
https://doi.org/10.14800/ccm.773

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Genomic diversity in established melanoma cell lines and human melanoma tumors

Autor: Thomas H. Hampton, Craig R. Tomlinson, Marc S. Ernstoff, Jan L. Fisher, Mary Jo Turk, David W. Mullins, Polina Shindiapina, Camilo E. Fadul, Chery A. Whipple

Publikováno v: Journal of Clinical Oncology. 34:e13001-e13001

e13001Background: Melanoma progression is often associated with a mutation in the BRAF oncogene that promotes constitutive activation of the MAPK signaling cascade. Analysis of malignant transforma...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9700310308a631264d940c0964688c6
https://doi.org/10.1200/jco.2016.34.15_suppl.e13001

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A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis

Autor: Alison L. Young, Murray Korc, Chery A. Whipple

Publikováno v: Oncogene

Pancreatic ductal adenocarcinomas (PDACs) exhibit multiple molecular alterations and overexpress heparin binding growth factors (HBGFs) and glypican-1 (GPC1), a heparan sulfate proteoglycan that promotes efficient signaling by HBGFs. It is not known,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2484e1a26e9d2a65453ac4f2275453b9
https://pubmed.ncbi.nlm.nih.gov/21996748

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