Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Cherry I. Kingsley"'
Autor:
Masaki Hara, Cherry I. Kingsley, Simon Read, Stuart E. Turvey, Peter J. Morris, Fiona Powrie, Masanori Niimi, Kathryn J. Wood, Andrew Bushell
We present evidence that donor-reactive CD4+ T cells present in mice tolerant to donor alloantigens are phenotypically and functionally heterogeneous. CD4+ T cells contained within the CD45RBhigh fraction remained capable of mediating graft rejection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b50ac7192c14d88ab70da31d5941750
https://doi.org/10.4049/jimmunol.166.6.3789
https://doi.org/10.4049/jimmunol.166.6.3789
Background. Liver grafts transplanted across a major histocompatibility barrier are accepted spontaneously and induce donor specific tolerance in some species. Here, we investigated whether liver allograft acceptance is characterized by, and depends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00d3ee770663ab5b995bbdacd171511
https://ora.ox.ac.uk/objects/uuid:bca85bec-f7b1-46f5-ac04-603218873769
https://ora.ox.ac.uk/objects/uuid:bca85bec-f7b1-46f5-ac04-603218873769
Autor:
Vanessa Oliveira, Cherry I. Kingsley, Mahzuz Karim, Manuela Herber, Kathryn J. Wood, Birgit Sawitzki
Publikováno v:
The Journal of Experimental Medicine
The significance of cytokine production by CD4(+) regulatory T (T reg) cells after antigen exposure in vivo and its impact on their regulatory activity remains unclear. Pretreatment with donor alloantigen under the cover of anti-CD4 therapy generates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc42189626a6d9efe6cdb88126f1a72
https://doi.org/10.1084/jem.20050419
https://doi.org/10.1084/jem.20050419
Publikováno v:
Transplant International
Immunological tolerance or functional unresponsiveness to a transplant is arguably the only approach that is likely to provide long-term graft survival without the problems associated with life-long global immunosuppression. Over the past 50 years, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f529c5b49e3b7c944286d659acbd2950
https://doi.org/10.1111/j.1432-2277.2007.00533.x
https://doi.org/10.1111/j.1432-2277.2007.00533.x
Publikováno v:
The Journal of Immunology. 172:923-928
The capacity of naturally occurring autoreactive CD25+CD4+ regulatory T cells (Treg) to control immune responses both in vivo and in vitro is now well established. It has been demonstrated that these cells undergo positive selection within the thymus
Autor:
Masaki Hara, Bernd M. Spriewald, Peter J. Morris, Jeffrey A. J. Barbara, Oliver Witzke, Stuart E. Turvey, Kathryn J. Wood, Cherry I. Kingsley
Publikováno v:
Transplantation. 70:1641-1649
Background. It is widely believed that Th1 cells that secrete interferon-y are primarily involved in the rejection of allografts whereas Th2 cells [interleukin(IL) 4 and IL-10] are thought to be protective of this process. However, the exact role and
Autor:
Maria G. Castro, Stuart E. Turvey, Kathryn J. Wood, Adriana T. Larregina, Peter J. Morris, Pedro R. Lowenstein, Cherry I. Kingsley, Valeria Gonzalez-Nicolini
Publikováno v:
Transplantation. 69:1972-1976
Background Expression of Fas ligand (FasL, CD95L) within the local environment of an allograft may protect from rejection by inducing apoptosis of infiltrating T cells. However, there is mounting evidence that ectopic expression of FasL stimulates an
Publikováno v:
Transplantation. 76(3)
Background. Preoperative blood transfusion has had a significant historic impact on graft outcome in clinical kidney transplantation, and the effect has been widely replicated in many experimental transplant models. Although the mechanisms underlying
Autor:
A L Mellor, A Van Maurik, Cherry I. Kingsley, Nick D. Jones, C H Smith, M Hara, Peter J. Morris, Stuart E. Turvey, Kathryn J. Wood
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 166(4)
Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2Kb+ skin and islet allografts to rejection is
Autor:
Andrew Bushell, Masaki Hara, Peter J. Morris, Mahzuz Karim, Cherry I. Kingsley, Kathryn J. Wood
Publikováno v:
Transplantation Proceedings. 33:3829-3830