Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Cherrie H.T. Kong"'
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 313:H190-H199
The balance of Ca2+ influx and efflux regulates the Ca2+ load of cardiac myocytes, a process known as autoregulation. Previous work has shown that Ca2+ influx, via L-type Ca2+ current ( ICa), and efflux, via the Na+/Ca2+ exchanger (NCX), occur predom
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 43:88-94
Recently, a family of guanine nucleotide exchange factors have been identified in many cell types as important effectors of cyclic adenosine 3',5'-monophospahte (cAMP) signalling that is independent of protein kinase A (PKA). In the heart, investigat
Publikováno v:
E7080
E7073
Proceedings of the National Academy of Sciences of the United States of America
Kong, C, Rog-Zielinska, E, Kohl, P, Orchard, C & Cannell, M 2018, ' Solute movement in the t-tubule system of rabbit and mouse cardiomyocytes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 30, pp. E7073-E7080 . https://doi.org/10.1073/pnas.1805979115
E7073
Proceedings of the National Academy of Sciences of the United States of America
Kong, C, Rog-Zielinska, E, Kohl, P, Orchard, C & Cannell, M 2018, ' Solute movement in the t-tubule system of rabbit and mouse cardiomyocytes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 30, pp. E7073-E7080 . https://doi.org/10.1073/pnas.1805979115
Significance Microscopic invaginations of the surface membrane, called t-tubules, carry electrical and chemical signals into cardiomyocytes. Previous studies have found slow rates of solute exchange inside t-tubules and have suggested that diffusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5e5104c25b7e66f986f2ec9fdc8bc6
http://hdl.handle.net/10044/1/61500
http://hdl.handle.net/10044/1/61500
Autor:
Mark B. Cannell, Cherrie H.T. Kong
Publikováno v:
Cannell, M B & Kong, C HT 2017, ' Quenching the spark : Termination of CICR in the sub-microscopic space of the dyad ', Journal of General Physiology, vol. 149, no. 10, pp. 837-845 . https://doi.org/10.1085/jgp.201711807
The Journal of General Physiology
The Journal of General Physiology
Cardiac excitation-contraction (E-C) coupling is a transduction cascade that results in muscle contraction and subsequent relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca2+ channels (LCCs), and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d64ba3e12e45ffda362b7b556dbdbc
https://research-information.bris.ac.uk/en/publications/0c02b4e9-0a73-42df-b8dd-c070a0ea3c17
https://research-information.bris.ac.uk/en/publications/0c02b4e9-0a73-42df-b8dd-c070a0ea3c17
Publikováno v:
Journal of Molecular and Cellular Cardiology
Kong, C H T, Rog-Zielinska, E A, Kohl, P, Orchard, C & Cannell, M B 2017, ' Sub-microscopic analysis of t-tubule geometry in living cardiac ventricular myocytes using a shape-based analysis method ', Journal of Molecular and Cellular Cardiology, vol. 108, pp. 1-7 . https://doi.org/10.1016/j.yjmcc.2017.05.003
Kong, C H T, Rog-Zielinska, E A, Kohl, P, Orchard, C & Cannell, M B 2017, ' Sub-microscopic analysis of t-tubule geometry in living cardiac ventricular myocytes using a shape-based analysis method ', Journal of Molecular and Cellular Cardiology, vol. 108, pp. 1-7 . https://doi.org/10.1016/j.yjmcc.2017.05.003
Transverse-axial tubules (TTs) are key structures involved in cardiac excitation-contraction coupling and can become deranged in disease. Although optical measurement of TTs is frequently employed to assess TT abundance and regularity, TT dimensions
Autor:
Simon M. Bryant, Anabelle Chase, Andrew F. James, Cherrie H.T. Kong, Judy J. Watson, M.Saadeh Suleiman, Clive H. Orchard, Tomomi E. Kimura
Publikováno v:
Journal of Molecular and Cellular Cardiology
L-type Ca channels (LTCC), which play a key role in cardiac excitation–contraction coupling, are located predominantly at the transverse (t-) tubules in ventricular myocytes. Caveolae and the protein caveolin-3 (Cav-3) are also present at the t-tub
Publikováno v:
Biophysical Journal. 104:2149-2159
The factors responsible for the regulation of regenerative calcium-induced calcium release (CICR) during Ca2+ spark evolution remain unclear. Cardiac ryanodine receptor (RyR) gating in rats and sheep was recorded at physiological Ca2+, Mg2+, and ATP
Publikováno v:
Biophysical Journal. 114:289a
Publikováno v:
Biophysical Journal. 114:499a
Autor:
Jonathan Rowlinson, Oluwasomidotun O Idowu, Stephanie Soyombo, Costanza Emanueli, Paolo Madeddu, Atsuhiko Oikawa, Giuseppe Mangialardi, Cherrie H.T. Kong, Gianni D Angelini, Mohamed T. Ghorbel, Jules C. Hancox, Elisa Avolio, Hongwei Cheng, Megan M. Swim, Iker Rodriguez-Arabaolaza, Sadie C. Slater, Valeria Vincenza Alvino, Huidong Jia, Clive H. Orchard, Federica Riu, Massimo Caputo, Helen L Spencer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Living grafts produced by combining autologous heart‐resident stem/progenitor cells and tissue engineering could provide a new therapeutic option for definitive correction of congenital heart disease. The aim of the study was to investig