Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cherrie H T, Kong"'
Publikováno v:
Cells, Vol 13, Iss 17, p 1455 (2024)
The atrioventricular node (AVN) is a key component of the cardiac conduction system and takes over pacemaking of the ventricles if the sinoatrial node fails. IP3 (inositol 1,4,5 trisphosphate) can modulate excitability of myocytes from other regions
Externí odkaz:
https://doaj.org/article/4a47348269214342815b39f379da96ab
Autor:
Hanne C Gadeberg, Richard C Bond, Cherrie H T Kong, Guillaume P Chanoit, Raimondo Ascione, Mark B Cannell, Andrew F James
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156862 (2016)
BACKGROUND:T-tubules are invaginations of the sarcolemma that play a key role in excitation-contraction coupling in mammalian cardiac myocytes. Although t-tubules were generally considered to be effectively absent in atrial myocytes, recent studies o
Externí odkaz:
https://doaj.org/article/05e15242b8ac42268cd5f465f4792dbd
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 2, p e1002931 (2013)
The release of Ca from intracellular stores is key to cardiac muscle function; however, the molecular control of intracellular Ca release remains unclear. Depletion of the intracellular Ca store (sarcoplasmic reticulum, SR) may play an important role
Externí odkaz:
https://doaj.org/article/e4dee497024445bb90bc8c597112d83b
Autor:
Simon M, Bryant, Cherrie H T, Kong, Judy J, Watson, Hanne C, Gadeberg, David M, Roth, Hemal H, Patel, Mark B, Cannell, Andrew F, James, Clive H, Orchard
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
Caveolin-3 (Cav-3) is a protein that has been implicated in t-tubule formation and function in cardiac ventricular myocytes. In cardiac hypertrophy and failure, Cav-3 expression decreases, t-tubule structure is disrupted, and excitation-contraction c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfd7eefce48d72aef21df6f173238259
https://pubmed.ncbi.nlm.nih.gov/30028203
https://pubmed.ncbi.nlm.nih.gov/30028203
Autor:
Simon M, Bryant, Cherrie H T, Kong, Judy J, Watson, Hanne C, Gadeberg, Andrew F, James, Mark B, Cannell, Clive H, Orchard
Publikováno v:
Experimental Physiology
New Findings What is the central question of this study? Heart failure is associated with redistribution of L‐type Ca2+ current (I Ca) away from the t‐tubule membrane to the surface membrane of cardiac ventricular myocytes. However, the underlyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41d82372d5cdc27fd3d11e07fdd5c664
https://pubmed.ncbi.nlm.nih.gov/29473235
https://pubmed.ncbi.nlm.nih.gov/29473235
Autor:
Cherrie H T, Kong, Simon M, Bryant, Judy J, Watson, Hanne C, Gadeberg, David M, Roth, Hemal H, Patel, Mark B, Cannell, Clive H, Orchard, Andrew F, James
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Aging is associated with diminished cardiac function in males. Cardiac excitation-contraction coupling in ventricular myocytes involves Ca influx via the Ca current (ICa) and Ca release from the sarcoplasmic reticulum, which occur predominantly at t-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38c5f92e86bad75928623e05f9ed0d74
https://pubmed.ncbi.nlm.nih.gov/29236992
https://pubmed.ncbi.nlm.nih.gov/29236992
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
This study shows that in contrast to the rat, mouse ventricular Na+/Ca2+ exchange current density is lower in the t-tubules than in the surface sarcolemma and Ca2+ current is predominantly located in the t-tubules. As a consequence, the t-tubules pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10f57c7c93bccac1c08b12a574113f94
https://pubmed.ncbi.nlm.nih.gov/28476922
https://pubmed.ncbi.nlm.nih.gov/28476922
Autor:
Simon M, Bryant, Cherrie H T, Kong, Judy, Watson, Mark B, Cannell, Andrew F, James, Clive H, Orchard
Publikováno v:
Journal of Molecular and Cellular Cardiology
In mammalian cardiac ventricular myocytes, Ca influx and release occur predominantly at t-tubules, ensuring synchronous Ca release throughout the cell. Heart failure is associated with disrupted t-tubule structure, but its effect on t-tubule function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::732fa5918713cfb091a287ff84d7dee4
https://pubmed.ncbi.nlm.nih.gov/26103619
https://pubmed.ncbi.nlm.nih.gov/26103619