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of 10
pro vyhledávání: '"Cherlyn Ng"'
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60490 (2013)
A fundamental problem in vision science is how useful perceptions and behaviors arise in the absence of information about the physical sources of retinal stimuli (the inverse optics problem). Psychophysical studies show that human observers contend w
Externí odkaz:
https://doaj.org/article/d548fd520d5c47c9b543754fa0d213ff
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12819 (2010)
The E3-ubiquitin ligase, c-Cbl, is a multi-functional scaffolding protein that plays a pivotal role in controlling cell phenotype. As part of the ubiquitination and downregulation process, c-Cbl recognizes targets, such as tyrosine kinases and the Sp
Externí odkaz:
https://doaj.org/article/8a5a78f131f4435a9148c9104d6a4667
Publikováno v:
Journal of Vision. 22:3751
Autor:
Soah Yee Chow, Xiao Woon Koh, Siu Kwan Sze, Jayaraman Seetharaman, Saravanan Sinniah, Jingru Qian, Jingxi Yew, Nur Farehan M Asgar, Manjeet Mukherjee, Yoon Pin Lim, Cherlyn Ng, Dan Li, J. Sivaraman, Rebecca A. Jackson, Graeme R. Guy, Audrey Iyu, Xingding Zhou, Permeen Yusoff, Daniel Yim
Publikováno v:
The EMBO Journal. 31:1308-1319
Phosphotyrosine-binding domains, typified by the SH2 (Src homology 2) and PTB domains, are critical upstream components of signal transduction pathways. The E3 ubiquitin ligase Hakai targets tyrosine-phosphorylated E-cadherin via an uncharacterized d
Publikováno v:
FEBS letters. 585(2)
Previously, we have demonstrated that the tyrosine phosphorylated hepatocyte growth factor receptor (Met) binds to the c-Cbl phosphotyrosine-recognition, tyrosine kinase binding (TKB) domain in a reverse orientation compared to other c-Cbl binding pa
Autor:
Teck Khiang Chua, Christopher Love, Bharat K. C. Patel, J. Sivaraman, Cherlyn Ng, Jayaraman Seetharaman, Joanna M. Kasprzak, Janusz M. Bujnicki
Publikováno v:
Journal of Structural Biology
Fructokinase (FRK; EC 2.7.1.4) catalyzes the phosphorylation of D-fructose to D-fructose 6-phosphate (F6P). This irreversible and near rate-limiting step is a central and regulatory process in plants and bacteria, which channels fructose into a metab
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Publikováno v:
The EMBO journal. 27(5)
The c‐Cbl tyrosine kinase binding domain (Cbl‐TKB), essentially an ‘embedded’ SH2 domain, has a critical role in targeting proteins for ubiquitination. To address how this domain can bind to disparate recognition mofits and to determine wheth
Publikováno v:
Journal of Vision. 14:968-968
Publikováno v:
Journal of Vision. 13:1158-1158
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 3, p e60490 (2013)
PLoS ONE, Vol 8, Iss 3, p e60490 (2013)
A fundamental problem in vision science is how useful perceptions and behaviors arise in the absence of information about the physical sources of retinal stimuli (the inverse optics problem). Psychophysical studies show that human observers contend w