The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

Autor: Vandermeulen, Charlotte, O’grady, Tina, Wayet, Jerome, Galvan, Bartimee, Maseko, Sibusiso, Cherkaoui, Majid, Desbuleux, Alice, Coppin, Georges, Olivet, Julien, Ben Ameur, Lamya, Kataoka, Keisuke, Ogawa, Seishi, Hermine, Olivier, Marcais, Ambroise, Thiry, Marc, Mortreux, Franck, Calderwood, Michael, van Weyenbergh, Johan, Peloponese, Jean-Marie, Charloteaux, Benoit, van den Broeke, Anne, Hill, David E., Vidal, Marc, Dequiedt, Franck, Twizere, Jean-Claude

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2021, 17 (9), pp.e1009919. ⟨10.1371/journal.ppat.1009919⟩
PLoS Pathogens, Vol 17, Iss 9, p e1009919 (2021)
P L o S Pathogens, 17 (9

Viral infections are known to hijack the transcription and translation of the host cell. However, the extent to which viral proteins coordinate these perturbations remains unclear. Here we used a model system, the human T-cell leukemia virus type 1 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::949667cb1a24868a4354d9ff33baa466
https://hal.science/hal-03400504/document

The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape.

Autor: Vandermeulen C; Laboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Laboratory of Gene Expression and Cancer, GIGA Institute, University of Liege, Liege, Belgium., O'Grady T; Laboratory of Gene Expression and Cancer, GIGA Institute, University of Liege, Liege, Belgium., Wayet J; Unit of Animal Genomics, GIGA, Université de Liège (ULiège), Liège, Belgium., Galvan B; Laboratory of Gene Expression and Cancer, GIGA Institute, University of Liege, Liege, Belgium., Maseko S; Laboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium., Cherkaoui M; Laboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium., Desbuleux A; Laboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America., Coppin G; Laboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America., Olivet J; Laboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America., Ben Ameur L; Laboratory of Biology and Modeling of the Cell, CNRS UMR 5239, INSERM U1210, University of Lyon, Lyon, France., Kataoka K; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Hermine O; Service Hématologie Adultes, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université de Paris, Laboratoire d'onco-hématologie, Institut Necker-Enfants Malades, INSERM U1151, Université de Paris, Paris, France., Marcais A; Service Hématologie Adultes, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université de Paris, Laboratoire d'onco-hématologie, Institut Necker-Enfants Malades, INSERM U1151, Université de Paris, Paris, France., Thiry M; Unit of Cell and Tissue Biology, GIGA Institute, University of Liege, Liege, Belgium., Mortreux F; Laboratory of Biology and Modeling of the Cell, CNRS UMR 5239, INSERM U1210, University of Lyon, Lyon, France., Calderwood MA; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America., Van Weyenbergh J; Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, Catholic University of Leuven, Leuven, Belgium., Peloponese JM; Université Montpellier, IRIM CNRS UMR 9004 Montpellier, France., Charloteaux B; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Human Genetics, CHU of Liege, University of Liege, Liege, Belgium., Van den Broeke A; Unit of Animal Genomics, GIGA, Université de Liège (ULiège), Liège, Belgium.; Laboratory of Experimental Hematology, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium., Hill DE; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America., Vidal M; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America., Dequiedt F; Laboratory of Gene Expression and Cancer, GIGA Institute, University of Liege, Liege, Belgium., Twizere JC; Laboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2021 Sep 20; Vol. 17 (9), pp. e1009919. Date of Electronic Publication: 2021 Sep 20 (Print Publication: 2021).