Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Cherie T, Ng"'
Autor:
Samantha A. Chalmers, Rajalakshmy Ayilam Ramachandran, Sayra J. Garcia, Evan Der, Leal Herlitz, Jeanette Ampudia, Dalena Chu, Nicole Jordan, Ting Zhang, Ioannis Parodis, Iva Gunnarsson, Huihua Ding, Nan Shen, Michelle Petri, Chi Chiu Mok, Ramesh Saxena, Krishna R. Polu, Stephen Connelly, Cherie T. Ng, Chandra Mohan, Chaim Putterman
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
T cells are central to the pathogenesis of lupus nephritis (LN), a common complication of systemic lupus erythematosus (SLE). CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM), are involved in T cell activation and trafficking. P
Externí odkaz:
https://doaj.org/article/5da04dc9777b4f09af0bd8b936c10fd9
Publikováno v:
Journal of Virology. 90:10102-10112
Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever disease in humans and pose serious public health concerns in their regions of endemicity. Moreover, mounting evidence indicates that the worldwide-distributed prototypic arenav
Autor:
Kristen Jepsen, Trey Ideker, Jason F. Kreisberg, Hui Shen, Susan Swindells, Howard S. Fox, Ken Flagg, Brenda Morsey, Philipp A. Jaeger, Cherie T. Ng, Mahdieh Khosroheidari, Andrew M. Gross, Daniel Chen, Kang Zhang, Katherine Licon
Publikováno v:
Molecular Cell. 62:157-168
HIV-infected individuals are living longer on antiretroviral therapy, but many patients display signs that in some ways resemble premature aging. To investigate and quantify the impact of chronic HIV infection on aging, we report a global analysis of
Autor:
Jason F. Kreisberg, Michael Kramer, Trey Ideker, Michael Ku Yu, Rohith Srivas, Nevan J. Krogan, Janusz Dutkowski, Katherine Licon, Cherie T. Ng, Roded Sharan
Publikováno v:
Cell systems
Summary Accurately translating genotype to phenotype requires accounting for the functional impact of genetic variation at many biological scales. Here we present a strategy for genotype-phenotype reasoning based on existing knowledge of cellular sub
Publikováno v:
Cell. 164(3):349-352
Type I interferon (IFN-I) elicits a complex cascade of events in response to microbial infection. Here, we review recent developments illuminating the large number of IFN-I species and describing their unique biologic functions.
Autor:
Jeanette Ampudia, William W. Young-Greenwald, Jana Badrani, Sole Gatto, Adam Pavlicek, Taylor Doherty, Stephen Connelly, Cherie T Ng
Publikováno v:
The Journal of Immunology. 204:150.13-150.13
CD6 is a T-cell costimulatory receptor that has been implicated in the pathogenesis of multiple autoimmune and inflammatory diseases. Primarily expressed on CD4 T cells, CD6 promotes immune synapse formation, T-cell activation and T-cell migration vi
Blockade of Interferon Beta, but Not Interferon Alpha, Signaling Controls Persistent Viral Infection
Autor:
Brian M. Sullivan, Megan J. Welch, Kathleen C. F. Sheehan, Michael B. A. Oldstone, Stephanie R. Rice, Andrew M. Lee, Cherie T. Ng, Robert D. Schreiber, John R. Teijaro
Publikováno v:
Cell Host & Microbe. 17(5):653-661
SUMMARY Although type I interferon (IFN-I) is thought to be beneficial against microbial infections, persistent viral infections are characterized by high interferon signatures suggesting that IFN-I signaling may promote disease pathogenesis. During
Autor:
Cherie T. Ng, Megan J. Welch, Brian M. Sullivan, Rosana Gonzalez-Quintial, Michael B. A. Oldstone, Alessandro Zarpellon, John R. Teijaro, Kevin B. Walsh, Argyrios N. Theofilopoulos, Zaverio M. Ruggeri, Anthony H. Nguyen, Juan Carlos de la Torre, Roberto Baccala
Publikováno v:
Proceedings of the National Academy of Sciences. 111:8925-8930
The outcome of a viral infection reflects the balance between virus virulence and host susceptibility. The clone 13 (Cl13) variant of lymphocytic choriomeningitis virus--a prototype of Old World arenaviruses closely related to Lassa fever virus--elic
Autor:
Andrew M. Lee, Megan J. Welch, Michael B. A. Oldstone, Brian M. Sullivan, Kathleen C. F. Sheehan, Cherie T. Ng, Robert D. Schreiber, John R. Teijaro, Juan Carlos de la Torre
Publikováno v:
Science. 340:207-211
INTERFER(ON)ing Persistence During persistent viral infections, a dysregulated immune response fails to control the infection. Wilson et al. (p. 202 ) and Teijaro et al. (p. 207 ; see the Perspective by Odorizzi and Wherry ) show this occurs because
Publikováno v:
Proceedings of the National Academy of Sciences. 109:7823-7828
Fibroblastic reticular cells (FRCs) are lymphoid stromal cells essential to T-cell migration and survival. Although FRCs are targets of multiple viral infections, little is known about their role during infection due to the cells’ scarcity and diff