Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.

Autor: Nam A; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Jain S; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California.; Department of Neurology, University of California, Irvine, Irvine, California., Wu C; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Campos A; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Shepard RM; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Yu Z; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Reddy JP; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Von Schalscha T; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Weis SM; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Onaitis M; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Wettersten HI; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California., Cheresh DA; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, California.

Publikováno v: Cancer research [Cancer Res] 2024 May 15; Vol. 84 (10), pp. 1630-1642.

Targeting the αVβ3/NgR2 pathway in neuroendocrine prostate cancer.

Autor: Testa A; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States., Quaglia F; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States., Naranjo NM; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States., Verrillo CE; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States., Shields CD; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States., Lin S; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States., Pickles MW; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States., Hamza DF; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States., Von Schalscha T; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, United States., Cheresh DA; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, United States., Leiby B; Division of Biostatistics, Department of Pharmacology, Physiology, and Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States., Liu Q; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, United States., Ding J; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, United States., Kelly WK; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, United States., Hooper DC; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States., Corey E; Department of Urology, University of Washington, Seattle, WA, United States., Plow EF; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States., Altieri DC; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, United States., Languino LR; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA, United States; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States.

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2023 Dec; Vol. 124, pp. 49-62. Date of Electronic Publication: 2023 Nov 11.

Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.

Autor: Wu C; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Rakhshandehroo T; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.; Department of Radiology, Dana-Farber Cancer Institute, Harvard University, Boston, MA, USA., Wettersten HI; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Campos A; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., von Schalscha T; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Jain S; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Yu Z; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Tan J; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Mose E; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Childers BG; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Lowy AM; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Weis SM; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Cheresh DA; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA. dcheresh@health.ucsd.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2023 Feb; Vol. 25 (2), pp. 309-322. Date of Electronic Publication: 2023 Jan 16.

Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC.

Autor: Che, Xiangxian^1,2 (AUTHOR), Tian, Xi^1,2,3 (AUTHOR), Wang, Zhenda^1,2,3 (AUTHOR), Zhu, Shuxuan^1,2,3 (AUTHOR), Ye, Shiqi^1,2,3 (AUTHOR), Wang, Yue^1,2,3 (AUTHOR), Chen, Yihan² (AUTHOR), Huang, Yiyun² (AUTHOR), Anwaier, Aihetaimujiang^1,2,3 (AUTHOR), Yao, Peifeng⁴ (AUTHOR), Chen, Yijia² (AUTHOR), Wu, Keting² (AUTHOR), Liu, Yifei² (AUTHOR), Xu, Wenhao^1,2,3 (AUTHOR) xwhao0407@163.com, Zhang, Hailiang^1,2,3 (AUTHOR) zhanghl918@163.com, Ye, Dingwei^1,2,3 (AUTHOR) dwyelie@163.com

Publikováno v: Cancer Cell International. 11/5/2024, Vol. 24 Issue 1, p1-18. 18p.

Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes.

Autor: Wu, Ying-Chieh¹ (AUTHOR), Lehtonen, Šárka^1,2 (AUTHOR) sarka.lehtonen@uef.fi, Trontti, Kalevi¹ (AUTHOR), Kauppinen, Riitta¹ (AUTHOR), Kettunen, Pinja¹ (AUTHOR), Leinonen, Ville^3,4 (AUTHOR), Laakso, Markku⁴ (AUTHOR), Kuusisto, Johanna^4,5 (AUTHOR), Hiltunen, Mikko⁶ (AUTHOR), Hovatta, Iiris⁷ (AUTHOR), Freude, Kristine⁸ (AUTHOR), Dhungana, Hiramani¹ (AUTHOR), Koistinaho, Jari^9,10 (AUTHOR) jari.koistinaho@helsinki.fi, Rolova, Taisia¹ (AUTHOR) taisia.rolova@helsinki.fi

Publikováno v: Fluids & Barriers of the CNS. 9/27/2024, Vol. 21 Issue 1, p1-20. 20p.