Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cher Sha"'
Autor:
Jun Li, Beisi Xu, Minghong He, Xinying Zong, Trevor Cunningham, Cher Sha, Yiping Fan, Richard Cross, Jacob H. Hanna, Yongqiang Feng
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110124- (2021)
Summary: Regulatory T (Treg) cells play crucial roles in suppressing deleterious immune response. Here, we investigate how Treg cells are mechanistically induced in vitro (iTreg) and stabilized via transcriptional regulation of Treg lineage-specifyin
Externí odkaz:
https://doaj.org/article/92d80b6395ec48018086fa7885430230
Autor:
Yiran Liu, Cher Sha, Alberto Ambesi-Impiombato, Michael C. Ostrowski, Erin Kim, Theresa M. Keeley, Jahnavi K. Nalamolu, Qing Wang, Mark Y. Chiang, Adolfo A. Ferrando, Ran Yan, Rohan Kodgule, Russell J.H. Ryan, Arvind Rao, Nicholas Kunnath, Linda C. Samuelson, Barbara L. Kee, Giusy Della Gatta, Anna C. McCarter, Rork Kuick, Ashley Melnick, Mengxi Sun
Publikováno v:
Blood Cancer Discov
Notch activation is highly prevalent among cancers, in particular T-cell acute lymphoblastic leukemia (T-ALL). However, the use of pan-Notch inhibitors to treat cancers has been hampered by adverse effects, particularly intestinal toxicities. To circ
Autor:
Yiran Liu, Cher Sha, Qing Wang, Mark Y. Chiang, Tomasz Cierpicki, Nancy Pinnell, Noah F. Garber, Ivy T. Tran, Qingqing Wu, Yitong Chen, Anna C. McCarter, Ivan Maillard, Yeonjoo Oh, Ran Yan, Rork Kuick, Amparo Serna Alarcon, Chia Jui Ku, James Douglas Engel
Publikováno v:
Blood. 132(12)
Notch1 signaling must elevate to high levels in order to drive the proliferation of CD4(−)CD8(−) double-negative (DN) thymocytes and progression to the CD4(+)CD8(+) double-positive (DP) stage through β-selection. During this critical phase of pr
Autor:
Mark Y. Chiang, Yiran Liu, Cher Sha, Rork Kuick, Amparo Serna Alarcon, Michael C. Ostrowski, Erin Kim, Linda C. Samuelson, Qing Wang, Anna C. McCarter, Moshe Talpaz, Russell J.H. Ryan, Catherine Chang, Luke F. Peterson, Ran Yan
Publikováno v:
Blood. 132:2595-2595
The discovery of NOTCH1 as the most frequently mutated oncogene in T-ALL patients raised hopes for targeted therapy in this cancer. Unfortunately, in clinical trials, the pan-Notch inhibitor GSI caused excessive GI toxicity. Mice treated continuously
Autor:
Qing Wang1, Ran Yan1,2, Pinnell, Nancy1, McCarter, Anna C.3, Yeonjoo Oh1, Yiran Liu1, Cher Sha1, Garber, Noah F.1, Yitong Chen1, Qingqing Wu4, Chia-Jui Ku5, Tran, Ivy6, Alarcon, Amparo Serna1, Kuick, Rork7, Engel, James Douglas5, Maillard, Ivan1,6,8,9, Cierpicki, Tomasz10, Chiang, Mark Y.1 markchia@umich.edu
Publikováno v:
Blood. 9/20/2018, Vol. 132 Issue 12, p1279-1292. 14p.