Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing.

Autor: Chen H; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Auditory Neuroscience and Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.; Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany., Monga M; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.; Biochemistry of Membrane Dynamics Group, Institute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany., Fang Q; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Auditory Neuroscience and Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany., Slitin L; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.; Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany., Neef J; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Auditory Neuroscience and Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany., Chepurwar SS; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.; Auditory Systems Physiology Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany., Netto RCM; Departamento de Genética e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-220, Brazil., Lezirovitz K; Laboratório de Otorrinolaringologia/LIM32, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP 05508-220, Brazil., Tabith A Jr; DERDIC, Pontifícia Universidade Católica de São Paulo, São Paulo 05508-220, Brazil., Benseler F; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany., Brose N; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.; Multiscale Bioimaging Cluster of Excellence (MBExC), University of Göttingen, 37075 Göttingen, Germany., Kusch K; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Functional Auditory Genomics Group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, 37077 Göttingen, Germany., Wichmann C; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany.; Multiscale Bioimaging Cluster of Excellence (MBExC), University of Göttingen, 37075 Göttingen, Germany., Strenzke N; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Auditory Systems Physiology Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany., Vona B; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Hearing Genomics Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Institute of Human Genetics, University Medical Center Göttingen, 37075 Göttingen, Germany., Preobraschenski J; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Biochemistry of Membrane Dynamics Group, Institute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany.; Multiscale Bioimaging Cluster of Excellence (MBExC), University of Göttingen, 37075 Göttingen, Germany., Moser T; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.; Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.; Auditory Neuroscience and Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.; Multiscale Bioimaging Cluster of Excellence (MBExC), University of Göttingen, 37075 Göttingen, Germany.

Publikováno v: Protein & cell [Protein Cell] 2024 Apr 01; Vol. 15 (4), pp. 305-312.