Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation.

Autor: Park KC; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Crump NT; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Louwman N; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Krywawych S; Department of Chemical Pathology, Great Ormond Street Hospital NHS Foundation Trust, London, UK., Cheong YJ; Epigenetics & Signalling Programmes, Babraham Institute, Cambridge, UK., Vendrell I; Nuffield Department of Medicine, Target Discovery Institute, Oxford, UK.; Nuffield Department of Medicine, Chinese Academy for Medical Sciences Oxford Institute, University of Oxford, Oxford, UK., Gill EK; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Gunadasa-Rohling M; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Ford KL; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Hauton D; Department of Chemistry, University of Oxford, Oxford, UK., Fournier M; Department of Biochemistry, University of Oxford, Oxford, UK., Pires E; Department of Chemistry, University of Oxford, Oxford, UK., Watson L; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Roseman G; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Holder J; Department of Biochemistry, University of Oxford, Oxford, UK., Koschinski A; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Carnicer R; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Curtis MK; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Zaccolo M; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Hulikova A; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK., Fischer R; Nuffield Department of Medicine, Target Discovery Institute, Oxford, UK.; Nuffield Department of Medicine, Chinese Academy for Medical Sciences Oxford Institute, University of Oxford, Oxford, UK., Kramer HB; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK., McCullagh JSO; Department of Chemistry, University of Oxford, Oxford, UK., Trefely S; Epigenetics & Signalling Programmes, Babraham Institute, Cambridge, UK., Milne TA; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Swietach P; Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023 Dec; Vol. 2, pp. 1221-1245. Date of Electronic Publication: 2023 Nov 23.