Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Cheol O Joe"'
Autor:
Sang Su Kwak, Mikyoung Jeong, Ji Hye Choi, Daesoo Kim, Hyesun Min, Yoosik Yoon, Onyou Hwang, Gary G Meadows, Cheol O Joe
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60803 (2013)
This study reports an amelioration of abnormal motor behaviors in tetrahydrobiopterin (BH4)-deficient Spr (-/-) mice by the dietary supplementation of tyrosine. Since BH4 is an essential cofactor for the conversion of phenylalanine into tyrosine as w
Externí odkaz:
https://doaj.org/article/18c8cbd401434201a96802813f866fd9
Autor:
Ji-Heon Choi, Hong Seok Jo, Soyeon Lim, Hyoung-Tai Kim, Kang Woo Lee, Kyeong Hwan Moon, Taejeong Ha, Sang Soo Kwak, Yeha Kim, Eun Jung Lee, Cheol O. Joe, Jin Woo Kim
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
One of the determinants of the neuronal subtype produced from retinal progenitor cells is their proliferative potential. Here the authors show that mTORC1 promotes progenitor cell cycle progression and hence accelerated development in mouse retina th
Externí odkaz:
https://doaj.org/article/4cdc58e73baf4679a3cf8a1bc28ef883
Autor:
Cheol O. Joe, Jeong Keun Ahn, Boohyeong Byun, Chan Hee Lee, Jin Woo Kim, Sang Su Kwak, Seung Beom Kim, Jinhwi Park, Jinkyu Suk, Jae Ho Lee
Supplementary Data from Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c0c8a81951fea066767c7d483a5eb7
https://doi.org/10.1158/1541-7786.22520916.v1
https://doi.org/10.1158/1541-7786.22520916.v1
Autor:
Cheol O. Joe, Jeong Keun Ahn, Boohyeong Byun, Chan Hee Lee, Jin Woo Kim, Sang Su Kwak, Seung Beom Kim, Jinhwi Park, Jinkyu Suk, Jae Ho Lee
We report a Notch signal–induced pathway that leads to transcriptional activation of HIF1-α gene. HeLa/rtTAA/TRE-N1-IC cell line capable of doxycycline-induced expression of human Notch1-IC was established. The induction of Notch signaling activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335dfbdac80b2b956efd500663c551bc
https://doi.org/10.1158/1541-7786.c.6542829
https://doi.org/10.1158/1541-7786.c.6542829
Autor:
Sang Su Kwak, Jeung-Hoon Lee, Jin Woo Kim, Kyung Hwa Kang, Gary G. Meadows, Cheol O. Joe, SeoEun Lee, Seyun Kim, Boohyeong Byun
Publikováno v:
Cellular Signalling. 28:32-41
We assign a new function to a tumor suppressor NPRL2 that activates the mTOR complex 1 (mTORC1) activity. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor. While NPRL2 interacts with Rag GTPases, R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2a75d6b90f29983558f67c67dfbc18
https://doi.org/10.1016/j.cellsig.2015.11.008
https://doi.org/10.1016/j.cellsig.2015.11.008
Autor:
Sang Soo Kwak, Hyoung-Tai Kim, Ji-heon Choi, Yeha Kim, Eun Jung Lee, Cheol O. Joe, Taejeong Ha, Kyeong Hwan Moon, Soyeon Lim, Kang Woo Lee, Hong Seok Jo, Jin Woo Kim
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
The numbers and types of cells constituting vertebrate neural tissues are determined by cellular mechanisms that couple neurogenesis to the proliferation of neural progenitor cells. Here we identified a role of mammalian target of rapamycin complex 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8ad06d73c71fdcaa38b0e3e107a3ce
https://doi.org/10.1038/s41467-018-04774-9
https://doi.org/10.1038/s41467-018-04774-9
Publikováno v:
Macromolecular Bioscience. 14:195-201
The high stiffness and low spatial charge density of siRNA limit the effectiveness of the electrostatic condensation of siRNA with cationic polyelectrolytes. Here, a facile method to stabilize nanoscale siRNA/polyelectrolyte complexes by introducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f34f0dda4ced79e986212a53b415240
https://doi.org/10.1002/mabi.201300291
https://doi.org/10.1002/mabi.201300291
Publikováno v:
The EMBO Journal. 31:817-828
Development of nervous tissue is a coordinated process of neural progenitor cell (NPC) proliferation and neuronal differentiation. Intracellular signalling events that regulate the balance between NPC proliferation and neuronal differentiation, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d24de7a23c7b5cce16ceca63e7305b9c
https://doi.org/10.1038/emboj.2011.443
https://doi.org/10.1038/emboj.2011.443
Autor:
Jin Woo Kim, Yong Hee Hong, Ya-Min Fu, Jinkyu Suk, Jeong Keun Ahn, Seungkyung Yang, Jae Hoon Chung, Cheol O. Joe, Hyesun Min, Sang Su Kwak, Ji Hye Choi, Dong Hwan Lee, Gary G. Meadows, Seonghyang Sohn
Publikováno v:
Autophagy. 7:1323-1334
Tetrahydrobiopterin (BH₄) deficiency is a genetic disorder associated with a variety of metabolic syndromes such as phenylketonuria (PKU). In this article, the signaling pathway by which BH₄ deficiency inactivates mTORC1 leading to the activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa8257563736baffebd881777de4683
https://doi.org/10.4161/auto.7.11.16627
https://doi.org/10.4161/auto.7.11.16627
Publikováno v:
Experimental Gerontology. 46:811-818
In order to better characterize epigenetic alterations at repetitive DNA elements with aging, DNA methylation and histone marks at various repeat classes were investigated. Repetitive DNA elements were hypermethylated in the brains of old mice. Histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ff350e9252080f58d5966ce51dc573
https://doi.org/10.1016/j.exger.2011.07.001
https://doi.org/10.1016/j.exger.2011.07.001