Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries

Autor: Bingbing Li, Chao Teng, Huiling Yu, Xiaohong Jiang, Xuyang Xing, Qi Jiang, Chenshi Lin, Zongmin Zhao, Ruifeng Zhang, Wei He

Publikováno v: Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2369-2382 (2023)

Pulmonary hypertension (PH) is an insidious pulmonary vasculopathy with high mortality and morbidity and its underlying pathogenesis is still poorly delineated. The hyperproliferation and apoptosis resistance of pulmonary artery smooth muscle cells (

Externí odkaz: https://doaj.org/article/c756bad29a564623a85a1cbb1220f150

Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

Autor: Chao Teng, Chenshi Lin, Feifei Huang, Xuyang Xing, Shenyu Chen, Ling Ye, Helena S. Azevedo, Chenjie Xu, Zhengfeng Wu, Zhongjian Chen, Wei He

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1521-1533 (2020)

Atherosclerosis (AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein, targeted codelivery of anti-miR 155 and anti-inflamm

Externí odkaz: https://doaj.org/article/06be8ffa40df4ed19563d3a6284c75a2

Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

Autor: Chenjie Xu, Shenyu Chen, Chao Teng, Zhengfeng Wu, Ling Ye, Zhongjian Chen, Feifei Huang, Xuyang Xing, Chenshi Lin, Wei He, Helena S. Azevedo

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1521-1533 (2020)
Acta Pharmaceutica Sinica. B

Atherosclerosis (AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein, targeted codelivery of anti-miR 155 and anti-inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a5656d74455742c9defca6dd75ab25
https://doi.org/10.1016/j.apsb.2020.06.005

CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma

Autor: Sen, Zhang, Na, Li, Yonghua, Yang, Yan, Li, Chenshi, Lin, Guoquan, Fu, Jun, Cai

Publikováno v: Medicine. 101:e29796

Adenocarcinoma is a non-small-cell lung cancer that is common cancer in both genders, and has poor clinical outcomes. We aimed to evaluate the role of cytoskeleton-associated protein 2 (CKAP2), its prognostic significance, and the relationship betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8122b16fb2bdeba2ea5466e27eca3afa
https://doi.org/10.1097/md.0000000000029796

Adipocyte Integrin-Linked Kinase Plays a Key Role in the Development of Diet-Induced Adipose Insulin Resistance in Male Mice

Autor: Li Kang, Rory J. McCrimmon, Chandani K. Hennayake, Chenshi Lin, David H. Wasserman, Michael L.J. Ashford, Annie Hasib, Aimée R. Bugler-Lamb, Xiong Weng, Roland H Stimson

Publikováno v: Bugler-Lamb, A R, Hasib, A, Weng, X, Hennayake, C K, Lin, C, McCrimmon, R J, Stimson, R H, Ashford, M L J, Wasserman, D H & Kang, L 2021, ' Adipocyte Integrin-Linked Kinase Plays a Key Role in the Development of Diet-Induced Adipose Insulin Resistance in Male Mice ', Molecular Metabolism . https://doi.org/10.1016/j.molmet.2021.101197
Molecular Metabolism
Molecular Metabolism, Vol 49, Iss, Pp 101197-(2021)

Objective Increased deposition of the extracellular matrix (ECM) in adipose tissue (AT) during obesity contributes to insulin resistance. The integrin receptors transmit changes in the extracellular environment causing corresponding intracellular ada

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2220c550f1ea5561ee9bcd4e29b8c6a
https://hdl.handle.net/20.500.11820/ac25f46a-e6be-44e7-9b61-148a81efc8d3