Novel nano-drug combination therapeutic regimen demonstrates significant efficacy in the transgenic mouse model of pancreatic ductal adenocarcinoma

Autor: Thakkar, Arvind, Desai, Preshita, Chenreddy, Sushma, Modi, Jalpa, Thio, Astrid, Khamas, Wael, Ann, David, Wang, Jeffrey, Prabhu, Sunil

The current work studied the chemopreventive efficacy of orally administered chitosan coated solid-lipid nanoparticle (c-SLN) encapsulated aspirin (ASP), curcumin (CUR) and free sulforaphane (SFN), ACS-cSLN, in the LSL-Kras G12D/+; Pdx-1 Cre/+ transg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3a8b067c4b1fc379a6db19c89613708
https://europepmc.org/articles/PMC6220149/

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Novel nano-drug combination therapeutic regimen demonstrates significant efficacy in the transgenic mouse model of pancreatic ductal adenocarcinoma.

Autor: Thakkar A; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences 309 E. 2nd Street, Pomona, CA 91766, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of New England Portland, ME 04103, USA., Desai P; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences 309 E. 2nd Street, Pomona, CA 91766, USA., Chenreddy S; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences 309 E. 2nd Street, Pomona, CA 91766, USA., Modi J; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences 309 E. 2nd Street, Pomona, CA 91766, USA., Thio A; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences 309 E. 2nd Street, Pomona, CA 91766, USA., Khamas W; College of Veterinary Medicine, Western University of Health Sciences 309 E. 2nd Street, Pomona, CA 91766, USA., Ann D; Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute City of Hope, Duarte, CA 91010, USA., Wang J; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences 309 E. 2nd Street, Pomona, CA 91766, USA., Prabhu S; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences 309 E. 2nd Street, Pomona, CA 91766, USA.

Publikováno v: American journal of cancer research [Am J Cancer Res] 2018 Oct 01; Vol. 8 (10), pp. 2005-2019. Date of Electronic Publication: 2018 Oct 01 (Print Publication: 2018).