Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chenqiang Jia"'
Autor:
Chenqiang Jia, Zhuqing Zhang, Jun Tang, Mei-Chun Cai, Jingyu Zang, Kaixuan Shi, Yunheng Sun, Jie Wu, Hailei Shi, Weiping Shi, Pengfei Ma, Xiaojing Zhao, Zhuang Yu, Yujie Fu, Guanglei Zhuang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited. Here, we performed integrative b
Externí odkaz:
https://doaj.org/article/8a9728e0f19446ac8ee076f4facdeab5
Autor:
Cong Huai, Gan Li, Ruijie Yao, Yingyi Zhang, Mi Cao, Liangliang Kong, Chenqiang Jia, Hui Yuan, Hongyan Chen, Daru Lu, Qiang Huang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
CRISPR-Cas9 is widely used for genome engineering but structural data for the DNA cleavage step are still incomplete. Here, the authors present the cryo-EM structure of a ternary Cas9-sgRNA-target DNA complex, perform MD simulations and discuss impli
Externí odkaz:
https://doaj.org/article/ebe04912ba9f4c5289a0cf88e17df27a
Autor:
Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang, Wen Di, Guanglei Zhuang
Publikováno v:
eLife, Vol 8 (2019)
PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-spec
Externí odkaz:
https://doaj.org/article/23227e3ca00146f3ae5aa1d88a5a76e5
Autor:
Li Tan, Guanglei Zhuang, Wen Di, Ying Li, Xia Yin, Meiying Zhang, Jingyu Zang, Huaijiang Xiang, Chenqiang Jia, Zhenfeng Zhang, Lifeng Lin, Kaiyan Ye, Mei-Chun Cai, Yan Cheng, Kaixuan Shi, Shaoqing Zhou, Shichao Zhou, Lin Cheng
Therapeutic perturbation of cyclin-dependent kinase 12 (CDK12) is proposed to have pleiotropic effects in ovarian cancer, including direct cytotoxicity against tumor cells and indirect induction of immunogenicity that confer synthetic sensitivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::803d54080f74b9b0c1964502a0fd65bb
https://doi.org/10.1158/0008-5472.c.6514152.v1
https://doi.org/10.1158/0008-5472.c.6514152.v1
Autor:
Li Tan, Guanglei Zhuang, Wen Di, Ying Li, Xia Yin, Meiying Zhang, Jingyu Zang, Huaijiang Xiang, Chenqiang Jia, Zhenfeng Zhang, Lifeng Lin, Kaiyan Ye, Mei-Chun Cai, Yan Cheng, Kaixuan Shi, Shaoqing Zhou, Shichao Zhou, Lin Cheng
Supplementary Data from Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539b32a67f2e7cb43c4fc786a31df263
https://doi.org/10.1158/0008-5472.22432443.v1
https://doi.org/10.1158/0008-5472.22432443.v1
Autor:
Lin Cheng, Shichao Zhou, Shaoqing Zhou, Kaixuan Shi, Yan Cheng, Mei-Chun Cai, Kaiyan Ye, Lifeng Lin, Zhenfeng Zhang, Chenqiang Jia, Huaijiang Xiang, Jingyu Zang, Meiying Zhang, Xia Yin, Ying Li, Wen Di, Guanglei Zhuang, Li Tan
Publikováno v:
Cancer research. 82(19)
Therapeutic perturbation of cyclin-dependent kinase 12 (CDK12) is proposed to have pleiotropic effects in ovarian cancer, including direct cytotoxicity against tumor cells and indirect induction of immunogenicity that confer synthetic sensitivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a42048d9c4d1d1c1bbe6f24a2c02d9
https://pubmed.ncbi.nlm.nih.gov/35857807
https://pubmed.ncbi.nlm.nih.gov/35857807
Autor:
Yujie Fu, Zhuang Yu, Mei-Chun Cai, Chenqiang Jia, Xiaojing Zhao, Xinying Xue, Minjiang Chen, Jie Wu, Li Tan, Peng-Fei Ma, Min Cao, Chunming He, Guanglei Zhuang
Publikováno v:
The Journal of pathologyReferences. 251(2)
Direct quantification of exhausted T cells in human cancer is lacking, and its predictive value for checkpoint-based treatment remains poorly investigated. We sought to systematically characterize the pan-cancer landscape and molecular hallmarks of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bc8aadc81e3bbc29529762626e8e72
https://pubmed.ncbi.nlm.nih.gov/32222046
https://pubmed.ncbi.nlm.nih.gov/32222046
Publikováno v:
Gene. 641:55-62
The detection of mutant DNA is critical for precision medicine, but low-frequency DNA mutation is very hard to be determined. CRISPR/Cas9 is a robust tool for in vivo gene editing, and shows the potential for precise in vitro DNA cleavage. Here we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9850092fb51553d6b5c7e7ffb74c43db
https://doi.org/10.1016/j.gene.2017.10.023
https://doi.org/10.1016/j.gene.2017.10.023
Autor:
Yingyi Zhang, Mi Cao, Liangliang Kong, Hongyan Chen, Daru Lu, Cong Huai, Hui Yuan, Qiang Huang, Gan Li, Chenqiang Jia, Ruijie Yao
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications
Nature Communications
CRISPR-Cas9 technology has been widely used for genome engineering. Its RNA-guided endonuclease Cas9 binds specifically to target DNA and then cleaves the two DNA strands with HNH and RuvC nuclease domains. However, structural information regarding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7b24c37324576d8a3049b2314515e4
https://doaj.org/article/ebe04912ba9f4c5289a0cf88e17df27a
https://doaj.org/article/ebe04912ba9f4c5289a0cf88e17df27a
Autor:
Peng-Fei Ma, Ying Yan, Mei-Chun Cai, Shi Kaixuan, Xia Yin, Wen Di, Chenqiang Jia, Zhenfeng Zhang, Zhenyu Gu, Guanglei Zhuang, Shengzhe Zhang, Meiying Zhang
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4288cf285f7329fdfeba815d9a976f61
https://elifesciences.org/articles/44306
https://elifesciences.org/articles/44306