Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chennekatu P. Peter"'
Morphological Changes in the Pituitary Gland of Dogs Chronically Exposed to Exogenous Growth Hormone
Autor:
Lea G. Stabinski, Matthew J. van Zwieten, Sylvain Molon-Noblot, Chennekatu P. Peter, Pierre Duprat, Srinivasa Prahalada, Philippe Laroque, Chao-Min Hoe
Publikováno v:
Toxicologic Pathology. 26:201-206
Growth hormone (GH) synthesis and release from the pituitary is regulated by hypothalamic releasing hormone, insulin-like growth factor-1 (IGF-1). and somatostatin. However, the potential effects of pharmacological doses of exogenous GH on the pituit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c33989fb20d4b23339a7ee07853d0b0b
https://doi.org/10.1177/019262339802600202
https://doi.org/10.1177/019262339802600202
Autor:
Lea G. Stabinski, Philippe Laroque, Sylvain Molon-Noblot, Pierre Duprat, Srinivasa Prahalada, Matthew J. van Zwieten, Chennekatu P. Peter, Chao-Min Hoe
Publikováno v:
Toxicologic Pathology. 26:207-212
Administration of growth hormone (GH) results in increased body weight gain in dogs. Increased body weight gain is believed to be a result of the trophic effect of GH on the musculoskeletal system. However, edema is one of the side effects described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d27d37f645c6356c17dbbb7bf7fbe19
https://doi.org/10.1177/019262339802600203
https://doi.org/10.1177/019262339802600203
Autor:
Howard Y. Chen, Chennekatu P. Peter, Lea G. Stabinski, Dan Holder, Darryl H. Patrick, Srinivasa Prahalada, Richard E. Morrissey, Matthew J. van Zwieten, Georges De Burlet
Publikováno v:
Toxicologic Pathology. 26:185-200
The purpose of this study was to evaluate the pharmacological and toxicological effects of exogenous GH administration in normal adult dogs. Because porcine GH (pGH) is structurally identical to canine GH, pGH was selected for a 14-wk study in dogs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5729b854cb405b9aa4c573f3fefd35ff
https://doi.org/10.1177/019262339802600201
https://doi.org/10.1177/019262339802600201
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 16:9-17
The results of 11 ocular irritation studies in rabbits, dogs, and monkeys treated with 2,3, or 4% dorzolamide hydrochloride (DZ), a new topical ocular carbonic anhydrase inhibitor, are presented. Additional interaction studies were conducted with oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659f2719e7f346691496bc46ed9a070d
https://doi.org/10.3109/15569529709048884
https://doi.org/10.3109/15569529709048884
Autor:
Chennekatu P. Peter, M.J. van Zwieten, Srinivasa Prahalada, Philippe Laroque, S M Cohen, Pierre Duprat, Keith A. Soper, S Molon-Noblot
Publikováno v:
The Prostate. 27:121-128
The objective of this study was to determine the effects of 2 different 5-alpha reductase inhibitors (finasteride and MK-0434) on the glandular and stromal compartments of hyperplastic canine prostates. In this study, dogs received 1 of the 2 compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d88f5c4d1156c6c089e8c2622cfc148
https://doi.org/10.1002/pros.2990270302
https://doi.org/10.1002/pros.2990270302
Autor:
Delwin L. Bokelman, Keith A. Soper, Matthew J. Van Zwieten, Srinivasa Prahalada, Phillip R. Hertzog, Kevin P. Keenan, Lea R. Gordon, Chennekatu P. Peter
Publikováno v:
Urology. 43:680-685
Objective. To determine any potential direct and/or indirect effects of elevated intraprostatic T levels on the prostates of rats chronically (1–2 years) exposed to high doses (160 mg/kg/day) of finasteride, a selective inhibitor of 5-alpha reducta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b85e03c3c79da427acfc45ff8e5b06
https://doi.org/10.1016/0090-4295(94)90184-8
https://doi.org/10.1016/0090-4295(94)90184-8
Autor:
Walter Bagdon, Joe D. Burek, Srinivasa Prahalada, M.J. van Zwieten, T. M. Nett, Keith A. Soper, Chennekatu P. Peter, J. A. Majka, James S. MacDonald
Publikováno v:
Fundamental and Applied Toxicology. 22:211-219
Finasteride is a selective inhibitor of the enzyme 5 alpha-reductase which is responsible for the conversion of testosterone (T) to dihydrotestosterone (DHT). Finasteride is indicated for the treatment of benign prostatic hyperplasia in man (approxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd1a3f30d93d8cfc24afc58add07895
https://doi.org/10.1006/faat.1994.1025
https://doi.org/10.1006/faat.1994.1025
Autor:
Peter H. Berry, Lea R. Gordon, Chennekatu P. Peter, Christine Boussiquet-Leroux, Nicholas Tonkonoh, G. Durand-Cavagna, Roger A. Owen, Sylvain Molon-Noblot
Publikováno v:
Toxicologic Pathology. 21:449-455
Renal papillary cytoplasmic granularity (RPCG) induced by carbonic anhydrase inhibitors (CAIs) in rats is characterized by the accumulation of dense secondary lysosomes in epithelial, endothelial, and interstitial cells and may be related to drug-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd3e694a4d4d7473356031ea6a882e5
https://doi.org/10.1177/019262339302100504
https://doi.org/10.1177/019262339302100504
Autor:
Mark A. Cukierski, Alice F. Tarantal, R. Tarara, Bill L. Lasley, R. T. Robertson, David L. Hess, Srinivasa Prahalada, Andrew G Hendrickx, Chennekatu P. Peter
Publikováno v:
Teratology. 46:429-438
Norfloxacin, an orally active fluoroquinolone antimicrobial, has been reported to be embryolethal but not teratogenic when administered to pregnant cynomolgus macaques prior to gestational day (GD) 36 at doses ≤200 mg/kg/day. Additional studies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a8f760af40772e6847b6b49d4c6e8d
https://doi.org/10.1002/tera.1420460507
https://doi.org/10.1002/tera.1420460507
Autor:
Christine Boussiquet-Leroux, Chennekatu P. Peter, G. Durand-Cavagna, Roger A. Owen, L. R. Gordon
Publikováno v:
Fundamental and Applied Toxicology. 18:137-143
Investigations of MK-0927 and acetazolamide, both carbonic anhydrase inhibitors (CAIs), showed that urothelial hyperplasia develops in rats and mice, but not in rabbits, dogs, or monkeys. Rats given MK-0927 orally had a rapid onset of the change whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141a3820553651091339178b26cb124c
https://doi.org/10.1016/0272-0590(92)90206-w
https://doi.org/10.1016/0272-0590(92)90206-w