Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chennagiri R. Pandit"'
Autor:
Ann J. Barbier, Steven B Sands, Lilian Y Li, Anthony Ndifor, Chandra R. Shah, Kirsten L. Morton, Michael A. Letavic, Timothy W. Lovenberg, Anne Bonneville, Heather McAllister, Neelakandha S. Mani, Ian Fraser, Kiev S. Ly, Richard Apodaca, Nicholas I. Carruthers, Manoj Bajpai, Swanson Devin M, Michelle Kramer, Christine Dugovic, Sandra S Snook, Chennagiri R. Pandit, Jonathan Shelton, Wei Xiao, Leah Aluisio, Pascal Bonaventure, Brian Lord, S Diane Nepomuceno
Publikováno v:
ACS Medicinal Chemistry Letters. 6:450-454
The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H3 receptor antagonists is described. The compounds described are high affinity histamine H3 antagonists. Optimization of the physical properties of these h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb111c3b07b944a678c3abee290cc57f
https://doi.org/10.1021/ml5005156
https://doi.org/10.1021/ml5005156
Autor:
Frank J. Villani, Neelakandha S. Mani, Lana K. Young, Pippel Daniel J, Hua M. Zhong, John E. Mills, Chennagiri R. Pandit
Publikováno v:
Organic Process Research & Development. 15:638-648
Our teams have recently completed scale-up campaigns for two structurally similar H3 receptor antagonists. The first and second generation processes were developed for the synthesis of 107 and 125 ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ec54479fbe7347a4c978f78fa8be4d
https://doi.org/10.1021/op200005e
https://doi.org/10.1021/op200005e
Autor:
Christopher M. Mapes, Shirin Shinde, Kelly J. McClure, Laurent Gomez, J. Guy Breitenbucher, Todd K. Jones, Clark A. Sehon, Neelakandha S. Mani, Marna C. W. Pippel, Xiaohu Deng, Chennagiri R. Pandit
Publikováno v:
The Journal of Organic Chemistry. 75:7950-7953
We describe a practical and scalable route to compound (Z)-1, a selective CCK1 receptor antagonist. Notable features of this concise route are (1) a regioselective construction of the pyrazole core through the reaction of an aryl hydrazine and an ela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13646b1c64bcf2dff772564571602c82
https://doi.org/10.1021/jo1017684
https://doi.org/10.1021/jo1017684
Publikováno v:
Synthesis. 2009:4032-4036
A novel, one-pot protocol for the direct reductive amination of aldehyde bisulfite adducts is reported. Bisulfite adducts of aliphatic and aromatic aldehydes, on treatment with an organic base under non-aqueous conditions liberate the aldehyde in sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a191a96c2ebe934aecbac81584b95ce2
https://doi.org/10.1055/s-0029-1217050
https://doi.org/10.1055/s-0029-1217050
Checkpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles
Autor:
Anders Brunmark, Danielle K. Neff, Shelby Crawford, Lars Karlsson, Kelly J. McClure, Alice Lee, J. Guy Breitenbucher, Chennagiri R. Pandit, Frank U. Axe, Kristen L. Arienti, Jon Blevitt, Liming Huang
Publikováno v:
Journal of Medicinal Chemistry. 48:1873-1885
The discovery of a series of novel, potent, and highly selective inhibitors of the DNA damage control kinase chk2 is disclosed. Here we report the first SAR study around inhibitors of this kinase. High-throughput screening of purified human chk2 led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3df8e2ecf621defa959c85adfd13db8
https://doi.org/10.1021/jm0495935
https://doi.org/10.1021/jm0495935
Autor:
Derek J. Norris, Rulin Zhao, Katerina Leftheris, John Hynes, Ping Chen, Bang-Chi Chen, Chennagiri R. Pandit, Lori A. Turk, Hong Wu, Vina Patil-Koota, Kathleen M. Gillooly, Peter A. Kiener, David J. Shuster, Xiaorong Chen, Kim W. McIntyre
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2399-2402
C-3 Amido-indoles were found to selectively bind to the CB2 receptor. SAR studies led to optimized compounds with excellent in vivo potency against LPS induced TNF-alpha release in murine models of cytokine production.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d4356bddddf4c047c7c78021673e09
https://doi.org/10.1016/s0960-894x(02)00466-3
https://doi.org/10.1016/s0960-894x(02)00466-3
Publikováno v:
Synthetic Communications. 32:2427-2432
A simple and economical method for 2-substituted oxazole synthesis and its scope are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5052362acd9019bfbf883a44cb0046bb
https://doi.org/10.1081/scc-120006015
https://doi.org/10.1081/scc-120006015
Publikováno v:
The Journal of Organic Chemistry. 58:3407-3410
Methylisothiazoles undergo phototransposition in neutral solution to methylthiazoles by a single permutation process. Methylisothiazole→methylisothiazole transpositions, previously reported to occur, were not detected in these reactions. In trifluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::646694c484b0814f13be6183bd960fa2
https://doi.org/10.1021/jo00064a033
https://doi.org/10.1021/jo00064a033
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748ce4505d8b12d84cc75a549b2c2b84
https://doi.org/10.1002/chin.199727232
https://doi.org/10.1002/chin.199727232
Autor:
Hong Wu, Joseph E. Sundeen, Chennagiri R. Pandit, Amanda P. Skoumbourdis, Katerina Leftheris, Bang-Chi Chen, John Hynes, Rulin Zhao
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8b5206302f69d52b42b614ce0c98a63
https://doi.org/10.1002/chin.200136120
https://doi.org/10.1002/chin.200136120