Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Chenming Zeng"'
Autor:
Minjie Hong, Xiaotian Zhou, Chenming Zeng, Demin Xu, Ting Xu, Shimiao Liao, Ke Wang, Chengming Zhu, Ge Shan, Xinya Huang, Xiangyang Chen, Xuezhu Feng, Shouhong Guang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Environmental stimuli not only alter gene expression profiles but also induce structural changes in cells. How distinct nuclear bodies respond to cellular stress is poorly understood. Here, we identify a subnuclear organelle named the nucleo
Externí odkaz:
https://doaj.org/article/f21fc205b1b043ecbabc073eacc16b99
Autor:
Xiangyang Chen, Ke Wang, Farees Ud Din Mufti, Demin Xu, Chengming Zhu, Xinya Huang, Chenming Zeng, Qile Jin, Xiaona Huang, Yong-hong Yan, Meng-qiu Dong, Xuezhu Feng, Yunyu Shi, Scott Kennedy, Shouhong Guang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Germ granules are biomolecular condensates present in most animal germ cells. One function of germ granules is to help maintain germ cell totipotency by organizing mRNA regulatory machinery, including small RNA-based gene regulatory pathways
Externí odkaz:
https://doaj.org/article/e60a6a28da724963b1079731422ad276
Autor:
Tao Yuan, Chenming Zeng, Jiawei Liu, Chenxi Zhao, Fujing Ge, Yuekang Li, Meijia Qian, Jiamin Du, Weihua Wang, Yonghao Li, Yue Liu, Xiaoyang Dai, Jianya Zhou, Xueqin Chen, Shenglin Ma, Hong Zhu, Qiaojun He, Bo Yang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Non-small cell lung cancer (NSCLC) ranks as one of the leading causes of cancer-related deaths worldwide. Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment, these drugs are suitable for and beneficial to
Externí odkaz:
https://doaj.org/article/f3833baff01f4f81b61eb42015e934f8
Autor:
Xiaoyang Wang, Chenming Zeng, Shanhui Liao, Zhongliang Zhu, Jiahai Zhang, Xiaoming Tu, Xuebiao Yao, Xuezhu Feng, Shouhong Guang, Chao Xu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
C. elegans piRNA biogenesis and chromosome segregation (PICS) complex is composed of TOFU-6, PICS-1, ERH-2, and two mutually exclusive factors PID-1 and TOST-1. By employing biochemical, structural, and cellular biology methods, the authors show that
Externí odkaz:
https://doaj.org/article/5e96c505b8154245861d516cea7565ea
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 947-960 (2020)
Hypoxia is a common feature of solid tumors. As transcription factors, hypoxia-inducible factors (HIFs) are the master regulators of the hypoxic microenvironment; their target genes function in tumorigenesis and tumor development. Intriguingly, both
Externí odkaz:
https://doaj.org/article/6fdbeee028bb4b19890692c71dd30ddb
Autor:
Chenming Zeng, Chenxi Zhao, Fujing Ge, Yuekang Li, Ji Cao, Meidan Ying, Jinjian Lu, Qiaojun He, Bo Yang, Xiaoyang Dai, Hong Zhu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Ubiquitination is known as important post-translational modification in cancer-related pathways. Human deubiquitinases (DUBs), with functions of modulating the ubiquitination process, are a family with about 100 proteins. They mainly function by cutt
Externí odkaz:
https://doaj.org/article/5dd1ea3c630a43d58e0a5a3e5fdb4cc5
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Low progesterone level is always linked with pre-term birth. Therefore, maintaining of progesterone level is vital during pregnancy. Aldo-keto reductase family one member C1 (AKR1C1) catalyzes the reduction of progesterone to its inactive form of 20-
Externí odkaz:
https://doaj.org/article/8537587ef4ad4e47ae672f95e268df57
Autor:
Chenming Zeng, Chenchun Weng, Xiaoyang Wang, Yong-Hong Yan, Wen-Jun Li, Demin Xu, Minjie Hong, Shanhui Liao, Meng-Qiu Dong, Xuezhu Feng, Chao Xu, Shouhong Guang
Publikováno v:
Cell Reports, Vol 27, Iss 12, Pp 3561-3572.e3 (2019)
Summary: piRNAs play significant roles in suppressing transposons and nonself nucleic acids, maintaining genome integrity, and defending against viral infections. In C. elegans, piRNA precursors are transcribed in the nucleus and are subjected to a n
Externí odkaz:
https://doaj.org/article/a45da87fa4a645468ec1bbfa3e9af2b3
Autor:
Pengfei Zhang, Qianfei Yang, Chenming Zeng, Shuangyin Wang, Jialong Shu, Chao Ma, Jianrong Wu
Publikováno v:
Proceedings of the 23rd Pacific Basin Nuclear Conference, Volume 2 ISBN: 9789811987793
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf2fd904554971e3cbde9c3be2d5725d
https://doi.org/10.1007/978-981-19-8780-9_41
https://doi.org/10.1007/978-981-19-8780-9_41
Publikováno v:
Nucleic Acids Research
The molecular mechanisms of aging are unsolved fundamental biological questions. Caenorhabditis elegans is an ideal model organism for investigating aging. PUF-8, a PUF (Pumilio and FBF) protein in C. elegans, is crucial for germline development thro