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A novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo–YAP signaling pathway

Autor: Chengyang Yu, Zhiqiang Zheng, Yongdong Yi, Weijian Sun, Wenqian Wang, Guojun Xia, Chunyan Hua, Fuyang Tu, Chenmin Ye, Leibin Shen, Canjin Chen

Publikováno v: OncoTargets and Therapy. 12:2259-2269

Chenmin Ye,1,2,* Wenqian Wang,3,* Guojun Xia,1,2,* Chengyang Yu,1,2 Yongdong Yi,1,2 Chunyan Hua,4 Fuyang Tu,1,2 Leibin Shen,1,2 Canjin Chen,1,2 Weijian Sun,1 Zhiqiang Zheng1 1Department of Gastrointestinal Surgery, The Second Affiliated Hospital and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ceee0b22a801374be017658b83bdd80
https://doi.org/10.2147/ott.s196914

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A novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo-YAP signaling pathway

Autor: Chenmin, Ye, Wenqian, Wang, Guojun, Xia, Chengyang, Yu, Yongdong, Yi, Chunyan, Hua, Fuyang, Tu, Leibin, Shen, Canjin, Chen, Weijian, Sun, Zhiqiang, Zheng

Publikováno v: OncoTargets and therapy

Purpose Gastric carcinoma is the second most frequently diagnosed cancer and leading cause of cancer death in China. As a new generation of cancer therapeutic drug, CL-6, a curcumin derivative, shows better bioavailability than curcumin, which has sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3cc41b07a554dd84c60675fe75030333
https://pubmed.ncbi.nlm.nih.gov/30988630

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Inhibitory effect of isavuconazole, ketoconazole, and voriconazole on the pharmacokinetics of methadone in vivo and in vitro

Autor: Jun Wang, Yongdong Yi, Chengyang Yu, Rongrong Wang, Zhiqiang Zheng, Fuyang Tu, Guojun Xia, Leibin Shen, Jingxuan Xu, Chenmin Ye

Publikováno v: Drug testing and analysis. 11(4)

The aim of this study was to investigate the possible effect of orally administered isavuconazole, ketoconazole, or voriconazole on the pharmacokinetics of methadone in rats. Twenty Sprague-Dawley (SD) rats were divided randomly into four groups: Gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a96d0cd0e170442fca21b59a2867da
https://pubmed.ncbi.nlm.nih.gov/30370647

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Nrf2-miR-129-3p-mTOR Axis Controls an miRNA Regulatory Network Involved in HDACi-Induced Autophagy

Autor: Chunya Hua, Zhi-qiang Zheng, Bin He, Canjin Chen, Yaxin Zhao, Chenmin Ye, Wenqian Wang, Xiaoying Xu, Guojun Xia, Weijian Sun, Xian Shen, Yaojun Yu, Yongdong Yi, Beng Yang, Fuyang Tu, Chengyang Yu, Liyi Li

Publikováno v: Mol Ther

Histone deacetylase inhibitors (HDACis) are the recommended treatment for many solid tumors; however, resistance is a major clinical obstacle for their efficacy. High levels of the transcription factor nuclear factor erythroid 2 like-2 (Nrf2) in canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4c085bccbde16a0eda6951977837a8
https://pubmed.ncbi.nlm.nih.gov/30852137

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The characteristics and pivotal roles of triggering receptor expressed on myeloid cells-1 in autoimmune diseases

Autor: Chenmin Ye, Guojun Xia, Yongdong Yi, Chunyan Hua, Chengyang Yu, Wenqian Wang, Sheng Gao, Fuyang Tu, Leibin Shen

Publikováno v: Autoimmunity reviews. 18(1)

Triggering receptor expressed on myeloid cells-1 (TREM-1) engagement can directly trigger inflammation or amplify an inflammatory response by synergizing with TLRs or NLRs. Autoimmune diseases are a family of chronic systemic inflammatory disorders.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b347bd08397fa99fa8f32f1ec3c3fc
https://pubmed.ncbi.nlm.nih.gov/30408584

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