Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Chenlei Wen"'
Autor:
Yizhi Cao, Xuelong Wang, Yang Liu, Pengyi Liu, Jiejie Qin, Youwei Zhu, Shuyu Zhai, Yongsheng Jiang, Yihao Liu, Lijie Han, Jiaxin Luo, Ronghao Zhang, Minmin Shi, Liwen Wang, Xiaomei Tang, Meilin Xue, Jia Liu, Weishen Wang, Chenlei Wen, Xiaxing Deng, Chenghong Peng, Hao Chen, Dongfeng Cheng, Lingxi Jiang, Baiyong Shen
Publikováno v:
Advanced Science, Vol 11, Iss 7, Pp n/a-n/a (2024)
Abstract Pancreatic cancer (PCa) is one of the most fatal human malignancies. The enhanced infiltration of stromal tissue into the PCa tumor microenvironment limits the identification of key tumor‐specific transcription factors and epigenomic abnor
Externí odkaz:
https://doaj.org/article/6df9a584624746ff8b1a120d7f95f5e7
Autor:
Siyi Zou, Xinjing Wang, Haoda Chen, Jiewei Lin, Chenlei Wen, Qian Zhan, Hao Chen, Xiongxiong Lu, Xiaxing Deng, Baiyong Shen
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Background Prognosis for patients recurred rapidly after resection of pancreatic ductal adenocarcinoma (PDAC) was extremely poor. We proposed the concept of postoperative hyper-progression disease (PO-HPD) to define recurrence within 2 month
Externí odkaz:
https://doaj.org/article/628fb87f9dc042258d88d1eec61327eb
Autor:
Qi Ai, Fanlu Li, Siyi Zou, Zehui Zhang, Yangbing Jin, Lingxi Jiang, Hao Chen, Xiaxing Deng, Chenghong Peng, Nan Mou, Chenlei Wen, Baiyong Shen, Qian Zhan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
KRAS mutation is a significant driving factor of tumor, and KRASG12V mutation has the highest incidence in solid tumors such as pancreatic cancer and colorectal cancer. Thus, KRASG12V neoantigen-specific TCR-engineered T cells could be a promising ca
Externí odkaz:
https://doaj.org/article/b4dde58416184cff8635d96bf9bbd609
Autor:
Yihao Liu, Minmin Shi, Xingfeng He, Yizhi Cao, Pengyi Liu, Fanlu Li, Siyi Zou, Chenlei Wen, Qian Zhan, Zhiwei Xu, Jiancheng Wang, Baofa Sun, Baiyong Shen
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-18 (2022)
Abstract Background LncRNA-PACERR plays critical role in the polarization of tissue-associated macrophages (TAMs). In this study, we found the function and molecular mechanism of PACERR in TAMs to regulate pancreatic ductal adenocarcinoma (PDAC) prog
Externí odkaz:
https://doaj.org/article/a4ba04ba4fb241959dc9fb19dbadd411
Autor:
Baiyong Shen, Yanyun Li, Chang-Sheng Sheng, Lili Liu, Tianzhichao Hou, Nan Xia, Siming Sun, Ya Miao, Yi Pang, Kai Gu, Xiongxiong Lu, Chenlei Wen, Yi Cheng, Yulin Yang, Dan Wang, Yijie Zhu, Minna Cheng, Katie Harris, Zachary T. Bloomgarden, Jingyan Tian, John Chalmers, Yan Shi
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 30, Iss , Pp 100596- (2023)
Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes durati
Externí odkaz:
https://doaj.org/article/8db08795b5bd46b9b91deb7bf6481b5e
Autor:
Chenlei Wen, XiaXing Deng, Dandan Ren, Xue Song, Hao Chen, Jiancheng Wang, Jiabin Jin, Dongfeng Cheng, Zhiwei Xu, Jun Zhang, Junjie Xie, Wenjing Qi, Jiangning Gu, Chenghong Peng, Dan Chen, Shi Chen, Baiyong Shen, Qian Zhan
Publikováno v:
Cancer Medicine, Vol 9, Iss 20, Pp 7626-7636 (2020)
Abstract Objective Our study examined the association between molecular features and clinical results of pancreatic ductal adenocarcinoma (PDAC) patients, aiming to explore the genomic determinants of the recurrence and prognosis of PDAC after surgic
Externí odkaz:
https://doaj.org/article/680b8eaaafd6493aaa2df6ddda4650ab
Autor:
Qian Zhan, Chenlei Wen, Yi Zhao, Lu Fang, Yangbing Jin, Zehui Zhang, Siyi Zou, Fanlu Li, Ying Yang, Lijia Wu, Jiabin Jin, Xiongxiong Lu, Junjie Xie, Dongfeng Cheng, Zhiwei Xu, Jun Zhang, Jiancheng Wang, XiaXing Deng, Hao Chen, Chenghong Peng, Hongwei Li, Henghui Zhang, Hai Fang, Chaofu Wang, Baiyong Shen
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103716- (2021)
Background: Pancreatic adenocarcinoma (PAAD) is one of the most lethal carcinomas, and the current histopathological classifications are of limited use in clinical decision-making. There is an unmet need to identify new biomarkers for prognosis-infor
Externí odkaz:
https://doaj.org/article/8368ecf9a37246a68cf63c55ab565e34
Autor:
Yangbing Jin, Zehui Zhang, Siyi Zou, Fanlu Li, Hao Chen, Chenghong Peng, Xiaxing Deng, Chenlei Wen, Baiyong Shen, Qian Zhan
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated death in the United States and has a 5-year survival rate of
Externí odkaz:
https://doaj.org/article/62316f55f8664d078dce59eb89a48032
Autor:
Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng, Baiyong Shen
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-14 (2017)
Abstract Background Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transition (EMT) to facilita
Externí odkaz:
https://doaj.org/article/4440eedccadc408fbba4f700faca03de
Autor:
Liwen Wang, Yihao Liu, Yuting Dai, Xiaomei Tang, Tong Yin, Chaofu Wang, Ting Wang, Lei Dong, Minmin Shi, Jiejie Qin, Meilin Xue, Yizhi Cao, Jia Liu, Pengyi Liu, Jinyan Huang, Chenlei Wen, Jun Zhang, Zhiwei Xu, Fan Bai, Xiaxing Deng, Chenghong Peng, Hao Chen, Lingxi Jiang, Saijuan Chen, Baiyong Shen
Publikováno v:
Gut. 72:958-971
ObjectiveInnate immunity plays important roles in pancreatic ductal adenocarcinoma (PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune system. Here, we aimed to explore the heterogeneity and pro-tumour mechanisms of