Výsledky vyhledávání

Akademický článek

A T-Shaped SOI Tunneling Field-Effect Transistor With Novel Operation Modes

Autor: Chenhe Liu, Qinghua Ren, Zhixi Chen, Lantian Zhao, Chang Liu, Qiang Liu, Wenjie Yu, Xinke Liu, Qing-Tai Zhao

Publikováno v: IEEE Journal of the Electron Devices Society, Vol 7, Pp 1114-1118 (2019)

We present a novel T-shaped tunneling field-effect transistor (TFET) on Si-on-insulator (SOI). The asymmetric source-drain structure can effectively suppress the ambipolar switching. The on-current ( $\text{I}_{\mathrm{ on}}$ )/off-current ( $\text{I

Externí odkaz: https://doaj.org/article/20a0c3ca7938449aa55030c916ec1985

Zobrazit plný text záznamu

Discovery of N-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)quinazolin-7-amine as a Novel, Potent, and Oral Cyclin-Dependent Kinase Inhibitor against Haematological Malignancies

Autor: Xiaoyue Liu, Tao Lu, Yadong Chen, Yanmin Zhang, Hongmei Li, Chenhe Liu, Xinren Wang, Tianyi Zhang, Ruinan Dong, Weifang Tang, Jianhang Huang, Shaohua Hou, Junyu Xu

Publikováno v: Journal of Medicinal Chemistry. 64:12548-12571

Hematologic malignancies (HM) start in blood forming tissue or in the cells of the immune system. Cyclin-dependent kinases (CDKs) regulate cell cycle progression, and some of them control cellular transcription. CDK inhibition can trigger apoptosis a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2779682ce07a571cedca7ebca1954546
https://doi.org/10.1021/acs.jmedchem.1c00271

Zobrazit plný text záznamu

Identification of N-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis

Autor: You Zhong, Qianqian Gao, Yuqin Zhu, Yanmin Zhang, Bo Kong, Junyu Xu, Haichun Liu, Jianing Song, Fei Jiang, Shuwen Li, Hua Wang, Yuxiang Ma, Hongmei Li, Tao Lu, Yadong Chen, Weidong Zu, Xinren Wang, Chenhe Liu

Publikováno v: Journal of Medicinal Chemistry. 63:6748-6773

A series of N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives with NF-κB inducing kinase (NIK) inhibitory activity were obtained through structure-based drug design and synthetic chemistry. A...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::108f2bee0cc05442ecd091f1d9b12767
https://doi.org/10.1021/acs.jmedchem.0c00055

Zobrazit plný text záznamu

Discovery of

Autor: Jianhang, Huang, Xinren, Wang, Ruinan, Dong, Xiaoyue, Liu, Hongmei, Li, Tianyi, Zhang, Junyu, Xu, Chenhe, Liu, Yanmin, Zhang, Shaohua, Hou, Weifang, Tang, Tao, Lu, Yadong, Chen

Publikováno v: Journal of medicinal chemistry. 64(17)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a38fcd37d87e506faa25816277826f4
https://pubmed.ncbi.nlm.nih.gov/34415148

Zobrazit plný text záznamu

Discovery of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and selective CDK9 inhibitors that enable transient target engagement for the treatment of hematologic malignancies

Autor: Xinren Wang, Xiaoyue Liu, Jianhang Huang, Chenhe Liu, Hongmei Li, Cong Wang, Qianqian Hong, Yan Lei, Jiawei Xia, Ziheng Yu, Ruinan Dong, Junyu Xu, Zhenlin Tu, ChunQi Duan, Shuwen Li, Tao Lu, Weifang Tang, Yadong Chen

Publikováno v: European Journal of Medicinal Chemistry. 238:114461

Cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and a potential therapeutic target in hematologic malignancies. Selective and transient CDK9 inhibition reduces Mcl-1 expression and induces apoptosis in Mcl-1-dependent tumor cells for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e90051f8254f324a4c8f2c9a806b78
https://doi.org/10.1016/j.ejmech.2022.114461

Zobrazit plný text záznamu

Discovery of coumarin derivatives as potent and selective cyclin-dependent kinase 9 (CDK9) inhibitors with high antitumour activity

Autor: Chenhe Liu, Yanmin Zhang, Ruinan Dong, Shuwen Li, Junyu Xu, Hongmei Li, Tao Lu, Yadong Chen, Chunqi Duan, Fei Jiang, Jianhang Huang, Tianyi Zhang, Gaoyuan Zhu, Xinren Wang, Weifang Tang, Yuqin Zhu

Publikováno v: European journal of medicinal chemistry. 200

Specific inhibition of CDK9 is considered a promising strategy for developing effective anticancer therapeutics. However, most of the reported CDK9 inhibitors are still at an early stage of development and lack selectivity against other CDKs. Herein,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f628cb4cae1b466b12145e29b05cb6e
https://pubmed.ncbi.nlm.nih.gov/32447197

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání