Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Chengzhang Fu"'
Autor:
Georges P. Schmartz, Jacqueline Rehner, Madline P. Gund, Verena Keller, Leidy-Alejandra G. Molano, Stefan Rupf, Matthias Hannig, Tim Berger, Elias Flockerzi, Berthold Seitz, Sara Fleser, Sabina Schmitt-Grohé, Sandra Kalefack, Michael Zemlin, Michael Kunz, Felix Götzinger, Caroline Gevaerd, Thomas Vogt, Jörg Reichrath, Lisa Diehl, Anne Hecksteden, Tim Meyer, Christian Herr, Alexey Gurevich, Daniel Krug, Julian Hegemann, Kenan Bozhueyuek, Tobias A. M. Gulder, Chengzhang Fu, Christine Beemelmanns, Jörn M. Schattenberg, Olga V. Kalinina, Anouck Becker, Marcus Unger, Nicole Ludwig, Martina Seibert, Marie-Louise Stein, Nikolas Loka Hanna, Marie-Christin Martin, Felix Mahfoud, Marcin Krawczyk, Sören L. Becker, Rolf Müller, Robert Bals, Andreas Keller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The human microbiome emerges as a promising reservoir for diagnostic markers and therapeutics. Since host-associated microbiomes at various body sites differ and diseases do not occur in isolation, a comprehensive analysis strategy highlight
Externí odkaz:
https://doaj.org/article/ebb47b78b5394a2ca2f41acd3fc0cf2a
Autor:
Chengzhang Fu, Yunkun Liu, Christine Walt, Sari Rasheed, Chantal D. Bader, Peer Lukat, Markus Neuber, F. P. Jake Haeckl, Wulf Blankenfeldt, Olga V. Kalinina, Rolf Müller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract DNA polymerase III sliding clamp (DnaN) was recently validated as a new anti-tuberculosis target employing griselimycins. Three (2 S,4 R)−4-methylproline moieties of methylgriselimycin play significant roles in target binding and metabolic
Externí odkaz:
https://doaj.org/article/7e4cc23e8e7b46028e890b8dfe93715d
Publikováno v:
Synthetic and Systems Biotechnology, Vol 8, Iss 4, Pp 640-646 (2023)
The biosynthetic potential of actinobacteria to produce novel natural products is still regarded as immense. In this paper, we correlated a cryptic biosynthetic gene cluster to chemical molecules by genome mining and chemical analyses, leading to the
Externí odkaz:
https://doaj.org/article/edda34fa0f0e4654bfd4a6852d44c206
Autor:
Jiaming Zhu, Peng Guo, Yuting Zheng, Shiqing Xiang, Yang Zhao, Xinyu Liu, Chengzhang Fu, Youming Zhang, Hai Xu, Ling Li, Wenjia Wang, Mingyu Wang
Publikováno v:
Biology, Vol 13, Iss 8, p 600 (2024)
Bacterial resistance to antibiotics can lead to long-lasting, hard-to-cure infections that pose significant threats to human health. One key mechanism of antimicrobial resistance (AMR) is to reduce the antibiotic permeation of cellular membranes. For
Externí odkaz:
https://doaj.org/article/b479e711e89b42cead696eb301a69966
Autor:
Judith Boldt, Laima Lukoševičiūtė, Chengzhang Fu, Matthias Steglich, Boyke Bunk, Vera Junker, Aileen Gollasch, Birte Trunkwalter, Kathrin I. Mohr, Michael Beckstette, Joachim Wink, Jörg Overmann, Rolf Müller, Ulrich Nübel
Publikováno v:
Microbial Biotechnology, Vol 16, Iss 5, Pp 1054-1068 (2023)
Abstract A better understanding of the genetic regulation of the biosynthesis of microbial compounds could accelerate the discovery of new biologically active molecules and facilitate their production. To this end, we have investigated the time cours
Externí odkaz:
https://doaj.org/article/d166ae2448294028b7cd1aaa50e27336
Autor:
Yunsheng Gao, Joy Birkelbach, Chengzhang Fu, Jennifer Herrmann, Herbert Irschik, Bernd Morgenstern, Kerstin Hirschfelder, Ruijuan Li, Youming Zhang, Rolf Jansen, Rolf Müller
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Myxobacteria serve as a treasure trove of secondary metabolites. During our ongoing search for bioactive natural products, a novel subclass of disorazoles termed disorazole Z was discovered. Ten disorazole Z family members were purified from
Externí odkaz:
https://doaj.org/article/a9bcc911fd694cd29d1fbf1aa2184424
Autor:
Chengzhang Fu, Asfandyar Sikandar, Jannik Donner, Nestor Zaburannyi, Jennifer Herrmann, Michael Reck, Irene Wagner-Döbler, Jesko Koehnke, Rolf Müller
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and
Externí odkaz:
https://doaj.org/article/65f014da62cb460088f5a5ff595c578a
Autor:
Jinsong Chen, Mei Liu, Xueting Liu, Jin Miao, Chengzhang Fu, Heyong Gao, Rolf Müller, Qing Zhang, Lixin Zhang
Publikováno v:
Synthetic and Systems Biotechnology, Vol 1, Iss 1, Pp 7-16 (2016)
The 2015 Nobel Prize in Physiology or Medicine has been awarded to avermectins and artemisinin, respectively. Avermectins produced by Streptomyces avermitilis are excellent anthelmintic and potential antibiotic agents. Because wild-type strains only
Externí odkaz:
https://doaj.org/article/28b561992c484a9d95ffbd93054e1bfd
Autor:
Hang Wu, Yansheng Wang, Li Yuan, Yongrong Mao, Weiwei Wang, Lin Zhu, Panpan Wu, Chengzhang Fu, Rolf Müller, David T. Weaver, Lixin Zhang, Buchang Zhang
Publikováno v:
Synthetic and Systems Biotechnology, Vol 1, Iss 1, Pp 39-46 (2016)
Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea; however, its biosynthetic cluster lacks a regulatory gene, limiting the yield enhancement via regulation engineering of S. erythraea. Herein, six TetR family transcri
Externí odkaz:
https://doaj.org/article/e47d1d79d04c4605adcfdc4a2ca15204
Autor:
Lena Keller, Emilia Oueis, Amninder Kaur, Nasim Safaei, Susanne H. Kirsch, Antonia P. Gunesch, Sibylle Haid, Ulfert Rand, Luka Čičin‐Šain, Chengzhang Fu, Joachim Wink, Thomas Pietschmann, Rolf Müller
Publikováno v:
Angewandte Chemie International Edition. 62
A new family of highly unusual sesquarterpenoids (persicamidines A-E) exhibiting significant antiviral activity was isolated from a newly discovered actinobacterial strain, Kibdelosporangium persicum sp. nov., collected from a hot desert in Iran. Ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eea0043dd46f9fc00955b9912f3f4dd
https://doi.org/10.1002/anie.202214595
https://doi.org/10.1002/anie.202214595