Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Chengzao Sun"'
Autor:
Anne M. Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J. Allen, Raymond J. Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A. Rodriguez, Xiaohua Xue, Arun Kannan, Teddy Kosoglou, Jonathan P. Sherlock, Jennifer Towne, M. Claire Holland, Nishit B. Modi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor
Externí odkaz:
https://doaj.org/article/a5c225b49e4844578be75fc534d1282c
Autor:
James L Trevaskis, Christine M Mack, Chengzao Sun, Christopher J Soares, Lawrence J D'Souza, Odile E Levy, Diane Y Lewis, Carolyn M Jodka, Krystyna Tatarkiewicz, Bronislava Gedulin, Swati Gupta, Carrie Wittmer, Michael Hanley, Bruce Forood, David G Parkes, Soumitra S Ghosh
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78154 (2013)
Combination therapy is being increasingly used as a treatment paradigm for metabolic diseases such as diabetes and obesity. In the peptide therapeutics realm, recent work has highlighted the therapeutic potential of chimeric peptides that act on two
Externí odkaz:
https://doaj.org/article/45ac3705572548328d3eb17134e3c0a8
Autor:
Gregory L. Adams, Parul S. Pall, Steven M. Grauer, Xiaoping Zhou, Jeanine E. Ballard, Marissa Vavrek, Richard L. Kraus, Pierre Morissette, Nianyu Li, Stefania Colarusso, Elisabetta Bianchi, Anandan Palani, Rebecca Klein, Christopher T. John, Deping Wang, Matthew Tudor, Andrew F. Nolting, Mirlinda Biba, Timothy Nowak, Alexey A. Makarov, Mikhail Reibarkh, Alexei V. Buevich, Wendy Zhong, Erik L. Regalado, Xiao Wang, Qi Gao, Aurash Shahripour, Yuping Zhu, Daniele de Simone, Tommaso Frattarelli, Nicolo’ Maria Pasquini, Paola Magotti, Roberto Iaccarino, Yuxing Li, Kelli Solly, Keun-Joong Lee, Weixun Wang, Feifei Chen, Haoyu Zeng, Jixin Wang, Hilary Regan, Rupesh P. Amin, Christopher P. Regan, Christopher S. Burgey, Darrell A. Henze, Chengzao Sun, David M. Tellers
Publikováno v:
Journal of Medicinal Chemistry. 65:485-496
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ecd04283fe1d38ba43c9ca77818a20e
https://doi.org/10.1021/acs.jmedchem.1c01570
https://doi.org/10.1021/acs.jmedchem.1c01570
The voltage-gated sodium channel Nav1.7 is being heavily pursued as a potential target for the treatment of pain based upon strong human genetic validation. A safe and effective Nav1.7 targeting molecule would require appropriate selectivity over mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0a8a2aeb2db3d5801de0dcf6c94a40a
https://doi.org/10.1039/9781788011532-00411
https://doi.org/10.1039/9781788011532-00411
Autor:
Bruce Forood, David G. Parkes, Jennifer Athanacio, Pete Griffin, Krystyna Tatarkiewicz, Manoj P. Samant, C.-H. Teng, Chengzao Sun, Yan Wang, Lawrence J. D'souza, James L. Trevaskis, Carrie Wittmer, J. D. Roth
Publikováno v:
Diabetes, Obesity and Metabolism. 17:61-73
Aim To test the impact of cholecystokinin (CCK) plus either amylin or a glucagon-like peptide-1 receptor (GLP-1R) agonist on metabolic variables in diet-induced obese (DIO) rodents. Methods A stabilized acetylated version of CCK-8 (Ac-Y*-CCK-8), sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6794c9e33f58c6d7977b395c3ef2fcbe
https://doi.org/10.1111/dom.12390
https://doi.org/10.1111/dom.12390
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5203-5208
C-terminal amidation is often a requisite structural feature for peptide hormone bio-activity. We report a chemical amidation method that converts peptide/protein thioesters into their corresponding C-terminal amides. The peptide/protein thioester is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaf5cf5172bf91e8e730e1483b79ec5
https://doi.org/10.1016/j.bmcl.2013.06.095
https://doi.org/10.1016/j.bmcl.2013.06.095
Autor:
Kim D. Janda, Tobin J. Dickerson, Chengzao Sun, Alexander V. Mayorov, Longwu Qi, Jennifer B. Treweek, Coree L. Levy, Amanda J. Roberts
Publikováno v:
Journal of Medicinal Chemistry. 51:6866-6875
One approach to treating drug abuse uses antidrug antibodies to immunize subjects against the illicit substance rather than administering therapeutics that target the specific CNS site of action. At present, passive vaccination has recognized efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ba727254cedc38ba81b2a3e3f50da5
https://doi.org/10.1021/jm800506v
https://doi.org/10.1021/jm800506v
Publikováno v:
Journal of the American Chemical Society. 130:11726-11736
A chiral enolate aggregate 1 containing a lithium enolate and a chiral lithium amide was systematically investigated by various NMR techniques. (1)H and (13)C DOSY at 25 and -78 degrees C provide its solution structure, aggregation number, and formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9243fd50c9c535389e043cea9f8e08b9
https://doi.org/10.1021/ja802114j
https://doi.org/10.1021/ja802114j
Publikováno v:
The Journal of Organic Chemistry. 73:2373-2381
A system consisting of a chiral lithium amide and n-BuLi in tol-d(8) solution was investigated with (1)H and (13)C INEPT DOSY, (6)Li and (15)N NMR, and other 2D NMR techniques. A mixed 2:1 trimeric complex was identified as the major species as the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19674578e7ac26c627094567a03a52c
https://doi.org/10.1021/jo702655m
https://doi.org/10.1021/jo702655m
Autor:
Angelo J. Castellino, Michael James Newman, Chengzao Sun, Zijian Guo, David L. Nelson, Trisha Eustaquio, Simon Eric Aspland, Carlo Ballatore, Qing Li, Philip Goelet, Rosario Silvestre Castillo, Joel Desharnais
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5194-5198
In the present work, we explore the possibility of introducing selectivity to existing chemotherapeutics via the design of non-pro-drug, bi-functional molecules comprising a microtubule-binding agent and a substrate for a disease-associated kinase. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627b7c2e9915c550d219d50194a32755
https://doi.org/10.1016/j.bmcl.2006.07.003
https://doi.org/10.1016/j.bmcl.2006.07.003