Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Chengyong WU"'
Autor:
Chengyong WU, Guangchao CAO, Kelong CHEN, Dingqiuying BA, Baokang LIU, Runke WANG, Yaya SHI, Chongyi E
Publikováno v:
Gaoyuan qixiang, Vol 43, Iss 3, Pp 802-808 (2024)
Gansu-Yellow River basin is a natural-social-economic complex ecosystem intertwined with ecological and development issues.Soil conservation service （SCS） is an important safeguard for preventing soil erosion and promoting high-quality developmen
Externí odkaz:
https://doaj.org/article/0e6907a36a2942dc9262b306798a7fb9
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTBackground CASC21 was reported to be a hotspot gene in cervical cancer. The relationship between CASC21 genetic polymorphisms and cervical cancer has not been reported. Genetic factors influence the occurrence of cervical cancer. Thus, we exp
Externí odkaz:
https://doaj.org/article/198f36531a2240d39b05a94cdf952d00
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1419-1436 (2023)
Currently, the knowledge of long noncoding RNA (lncRNA)‐encoded peptides is quite lacking in esophageal squamous cell carcinoma (ESCC). In this study, we simultaneously identified six lncRNA open reading frames (ORFs) with peptide‐coding abilitie
Externí odkaz:
https://doaj.org/article/224a066169a149d5bc066e9b3c2a6094
Publikováno v:
Research, Vol 7 (2024)
In this study, we systematically investigated the interactions between Cu2+ and various biomolecules, including double-stranded DNA, Y-shaped DNA nanospheres, the double strand of the hybridization chain reaction (HCR), the network structure of cross
Externí odkaz:
https://doaj.org/article/ec685d75832c41dcab890280d9fd7092
Autor:
Guan Wang, Yongya Wu, Chengyong Wu, Wen Shuai, Tingting Jiang, Aoxue Wang, Faqian Bu, Qiu Sun, Liang Ouyang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 440-443 (2023)
Externí odkaz:
https://doaj.org/article/b066f74405814fe6b8bfa98436c73216
Autor:
Yueshan Li, Liting Zhang, Yifei Wang, Jun Zou, Ruicheng Yang, Xinling Luo, Chengyong Wu, Wei Yang, Chenyu Tian, Haixing Xu, Falu Wang, Xin Yang, Linli Li, Shengyong Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Retrieval of a new starting active compound with a novel scaffold during early drug development is an important but challenging task. Here, the authors propose a generative deep learning model and by applying this model they discover a potent and hig
Externí odkaz:
https://doaj.org/article/75a88dd4da1d4bd8a674229c98de8eec
Autor:
Cancan Zhang, Huisha Xu, Keilah G. Netto, Leon A. Sokulsky, Yiyan Miao, Zhongyuan Mo, Yan Meng, Yingying Du, Chengyong Wu, Liyou Han, Lirong Zhang, Chi Liu, Guojun Zhang, Fuguang Li, Ming Yang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDespite recent advances, there are limited treatments available for acute asthma exacerbations. Here, we investigated the therapeutic potential of GGsTop, a γ-glutamyl transferase inhibitor, on the disease with a murine model of asthma e
Externí odkaz:
https://doaj.org/article/104dda0788d2428eac97eed7ddb9eca6
Autor:
Linna Cheng, Zejing Yang, Wenhao Guo, Chengyong Wu, Shufang Liang, Aiping Tong, Zhongwei Cao, Rick F. Thorne, Sheng-Yong Yang, Yamei Yu, Qiang Chen
Publikováno v:
The Innovation, Vol 3, Iss 1, Pp 100191- (2022)
Doublecortin-like kinase 1 (DCLK1) is upregulated in many tumors and is a marker for tumor stem cells. Accumulating evidence suggests DCLK1 constitutes a promising drug target for cancer therapy. However, the regulation of DCLK1 kinase activity is po
Externí odkaz:
https://doaj.org/article/c2ec26168b5c44ea99c771c7d09b3926
Autor:
Yuxi Wang, Yamei Yu, Guo-Bo Li, Shu-Ang Li, Chengyong Wu, Benoît Gigant, Wenming Qin, Hao Chen, Yangping Wu, Qiang Chen, Jinliang Yang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Microtubule-stabilizing agents (MSAs) promote the polymerization of tubulin and are of great interest as anticancer drugs. Here the authors present the crystal structure of the MSA taccalonolide AJ bound to tubulin and give insights into its mode of
Externí odkaz:
https://doaj.org/article/7eca1bb82aef4a84b8bbc010e8629fe9
Autor:
Jinghong Xian, Faqian Bu, Yuxi Wang, Fangyi Long, Zhixiong Zhang, Chengyong Wu, Yiran Tao, Ting Wang, Guan Wang
Publikováno v:
Molecules, Vol 26, Iss 4, p 946 (2021)
Microtubules composed of α/β tubulin heterodimers are an essential part of the cytoskeleton of eukaryotic cells and are widely regarded as targets for cancer chemotherapy. IC261, which is discovered as an ATP-competitive inhibitor of serine/threoni
Externí odkaz:
https://doaj.org/article/061e89553f434efdb2f181781b12a729