Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Chengyong Shen"'
Autor:
Wen-Yo Tu, Wentao Xu, Lei Bai, Jun Liu, Yi Han, Benyan Luo, Bingwei Wang, Kejing Zhang, Chengyong Shen
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114661- (2024)
Summary: Motor neurons are highly polarized, and their axons extend over great distances to form connections with myofibers via neuromuscular junctions (NMJs). Local translation at the NMJs in vivo has not been identified. Here, we utilized motor neu
Externí odkaz:
https://doaj.org/article/1e77ccedd1884ff99b961a8f4744b311
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Background Neuromuscular junctions (NMJs) are peripheral synapses connecting motoneurons and skeletal myofibers. At the postsynaptic side in myofibers, acetylcholine receptor (AChR) proteins are clustered by the neuronal agrin signal. Meanwh
Externí odkaz:
https://doaj.org/article/b2a8f334a6634e44b61484502482e662
Autor:
Xiaoqiu Shu, Chen Wei, Wen-Yo Tu, Keke Zhong, Shuyuan Qi, Ailian Wang, Lei Bai, Shan-Xin Zhang, Benyan Luo, Zhen-Zhong Xu, Kejing Zhang, Chengyong Shen
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112133- (2023)
Summary: Expansion of the hexanucleotide repeat GGGGCC in the C9orf72 gene is the most common genetic factor in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Poly-Gly-Ala (poly-GA), one form of dipeptide repeat proteins (DPRs
Externí odkaz:
https://doaj.org/article/20ae9442036d4b84baba553156c9a090
Autor:
Chengyong Shen, Lei Li, Kai Zhao, Lei Bai, Ailian Wang, Xiaoqiu Shu, Yatao Xiao, Jianmin Zhang, Kejing Zhang, Tiankun Hui, Wenbing Chen, Bin Zhang, Wei Hsu, Wen-Cheng Xiong, Lin Mei
Publikováno v:
eLife, Vol 7 (2018)
The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Unlike extensively investigated postsynaptic differentiation, less is known about mechanisms of presynaptic assembly. Genetic evidence o
Externí odkaz:
https://doaj.org/article/ab3bd57e151843409aab0203f27d5802
Autor:
Haitao Wu, Arnab Barik, Yisheng Lu, Chengyong Shen, Andrew Bowman, Lei Li, Anupama Sathyamurthy, Thiri W Lin, Wen-Cheng Xiong, Lin Mei
Publikováno v:
eLife, Vol 4 (2015)
Neuromuscular junction formation requires proper interaction between motoneurons and muscle cells. β-Catenin (Ctnnb1) in muscle is critical for motoneuron differentiation; however, little is known about the relevant retrograde signal. In this paper,
Externí odkaz:
https://doaj.org/article/55f661107abe43af8eadffe28bdc366d
Autor:
Mariapaola Marino, Flavia Scuderi, Daniela Samengo, Giorgia Saltelli, Maria Teresa Maiuri, Chengyong Shen, Lin Mei, Mario Sabatelli, Giovambattista Pani, Giovanni Antonini, Amelia Evoli, Emanuela Bartoccioni
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135378 (2015)
Myasthenia gravis (MG) is an autoimmune disease in which 90% of patients have autoantibodies against the muscle nicotinic acetylcholine receptor (AChR), while autoantibodies to muscle-specific tyrosine kinase (MuSK) have been detected in half (5%) of
Externí odkaz:
https://doaj.org/article/f32e1f61d1d3499f99f91be4a202d12b
Autor:
Bin Zhang, Chengyong Shen, Beverly Bealmear, Samia Ragheb, Wen-Cheng Xiong, Richard A Lewis, Robert P Lisak, Lin Mei
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91816 (2014)
To determine if patients with myasthenia gravis (MG) have antibodies to agrin, a proteoglycan released by motor neurons and is critical for neuromuscular junction (NMJ) formation, we collected serum samples from 93 patients with MG with known status
Externí odkaz:
https://doaj.org/article/9565778c8c2c416094f08b07aa0e7af6
Autor:
Chengyong Shen, Yong-Jun Chen
Publikováno v:
Bio-Protocol, Vol 3, Iss 17 (2013)
The understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphol
Externí odkaz:
https://doaj.org/article/dd3893bb6916460997c75b4701e90de7
Publikováno v:
Journal of Molecular Cell Biology
The neuromuscular junction (NMJ), a peripheral synaptic connection between motoneurons and skeletal muscle fibers, controls movement. Dysregulation of NMJs has been implicated in various motor disorders. Because of their large size and easy accessibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56067b8127e48a47cf998963b5504800
https://doi.org/10.1093/jmcb/mjab046
https://doi.org/10.1093/jmcb/mjab046
Autor:
Kai Zhao, Wei Jiang, Feixu Zhang, Xia Wu, Jiamei Wu, Zengmin Du, Ying Chen, Jing Zheng, Chengyong Shen, Xiao Xiao
Publikováno v:
Biochemical and Biophysical Research Communications. 537:125-131
Four-and-a-half LIM domain protein 1 (FHL1) is a member of the FHL protein family that serves as a scaffold protein to maintain normal cellular structure and function. Its mutations have been implicated in multiple muscular diseases. These FHL1 relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429ea4fafa1d37c2b2db851a1cb10cbd
https://doi.org/10.1016/j.bbrc.2020.12.061
https://doi.org/10.1016/j.bbrc.2020.12.061