Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chengsheng Han"'
Autor:
Huixia Ren, Yanjun Li, Chengsheng Han, Yi Yu, Bowen Shi, Xiaohong Peng, Tianming Zhang, Shufang Wu, Xiaojing Yang, Sneppen Kim, Liangyi Chen, Chao Tang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The Ca2+ modulated pulsatile glucagon and insulin secretions by pancreatic α and β cells are critical in glucose homeostasis. Here the authors show that the Ca2+ oscillations of α and β cells are phase-locked, and that the oscillation pattern is
Externí odkaz:
https://doaj.org/article/e49e286e87604eaf9caa443b9fcbdf5a
Autor:
Xiaoya Zhang, Xiaohong Peng, Chengsheng Han, Wenzhen Zhu, Lisi Wei, Yulin Zhang, Yi Wang, Xiuqin Zhang, Hao Tang, Jianshe Zhang, Xiaojun Xu, Fengping Feng, Yanhong Xue, Erlin Yao, Guangming Tan, Tao Xu, Liangyi Chen
Publikováno v:
Protein & Cell, Vol 10, Iss 4, Pp 306-311 (2018)
Externí odkaz:
https://doaj.org/article/4a926617d47f4f3aa59bc20c266e623f
Autor:
Yulin Zhang, Chengsheng Han, Wenzhen Zhu, Guoyi Yang, Xiaohong Peng, Sohum Mehta, Jin Zhang, Liangyi Chen, Yanmei Liu
Publikováno v:
Cells, Vol 10, Iss 9, p 2495 (2021)
Incretin-potentiated glucose-stimulated insulin secretion (GSIS) is critical to maintaining euglycemia, of which GLP-1 receptor (GLP-1R) on β-cells plays an indispensable role. Recently, α-cell-derived glucagon but not intestine-derived GLP-1 has b
Externí odkaz:
https://doaj.org/article/cc8531848cda40ecbf0f435d99a3d043
Autor:
Huixia Ren, Yanjun Li, Chengsheng Han, Yi Yu, Bowen Shi, Xiaohong Peng, Tianming Zhang, Shufang Wu, Xiaojing Yang, Sneppen Kim, Liangyi Chen, Chao Tang
Publikováno v:
Nature communications. 13(1)
The Ca2+ modulated pulsatile glucagon and insulin secretions by pancreatic α and β cells play a crucial role in glucose homeostasis. However, how α and β cells coordinate to produce various Ca2+ oscillation patterns is still elusive. Using a micr
Autor:
Xiaojun Xu, Liangyi Chen, Jianshe Zhang, Xiuqin Zhang, Fengping Feng, Tao Xu, Guangming Tan, Chengsheng Han, Xiaohong Peng, Hao Tang, Wenzhen Zhu, Yi Wang, Yulin Zhang, Erlin Yao, Lisi Wei, Yanhong Xue, Xiaoya Zhang
Publikováno v:
Protein & Cell
Protein & Cell, Vol 10, Iss 4, Pp 306-311 (2018)
Protein & Cell, Vol 10, Iss 4, Pp 306-311 (2018)
Autor:
Guoyi Yang, Shufang Wu, Huixia Ren, Xiaohong Peng, Xiaojing Yang, Yanjun Li, Chengsheng Han, Bowen Shi, Wenzhen Zhu, Yi Yu, Liangyi Chen, Kim Sneppen, Chao Tang
SUMMARYThe Ca2+ modulated pulsatile secretion of glucagon and insulin by pancreatic α and β cells plays a key role in glucose homeostasis. However, how α and β cells coordinate via paracrine interaction to produce various Ca2+ oscillation pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf2446a67120db2ee4a8450bd936880
https://doi.org/10.1101/2020.08.16.252304
https://doi.org/10.1101/2020.08.16.252304
Autor:
Wenda Hou, Chengsheng Han, Xi Wang, Ying Luo, Ivan Vuletic, Ni Su, Qiushi Ren, Wen-Xi Zhang, Liangyi Chen, Kai Wang
Publikováno v:
Biomaterials. 102:249-258
Implantable immunoisolation membranes need to possess superior biocompatibility to prohibit the fibrotic deposition that would reduce the nutrient supply and impair the viability/function of the encapsulated cells. Here, electrospun membranes based o
Autor:
Chengsheng Han, Wenzhen Zhu, Jin Zhang, Guoyi Yang, Sohum Mehta, Liangyi Chen, Yulin Zhang, Yanmei Liu, Xiaohong Peng
Publikováno v:
SSRN Electronic Journal.
Despite the well-known role of the GLP-1 receptor (GLP-1R) in potentiating glucose-stimulated insulin secretion (GSIS) and as a therapeutic drug target in diabetes treatment, how GLP-1R is activated under physiological and pathological conditions rem
Publikováno v:
Journal of Visualized Experiments.
Islet transplantation has been clinically proven to be effective at treating type 1 diabetes. However, the current intrahepatic transplantation strategy may incur acute whole blood reactions and result in poor islet engraftment. Here, we report a rob
Publikováno v:
Journal of cell science. 129(12)
Imbalanced glucagon and insulin release leads to the onset of type 2 diabetes. To pinpoint the underlying primary driving force, here we have developed a fast, non-biased optical method to measure ratios of pancreatic α- and β-cell mass and functio