Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Chengpeng Bi"'
Autor:
Warren A. Cheung, Adam F. Johnson, William J. Rowell, Emily Farrow, Richard Hall, Ana S. A. Cohen, John C. Means, Tricia N. Zion, Daniel M. Portik, Christopher T. Saunders, Boryana Koseva, Chengpeng Bi, Tina K. Truong, Carl Schwendinger-Schreck, Byunggil Yoo, Jeffrey J. Johnston, Margaret Gibson, Gilad Evrony, William B. Rizzo, Isabelle Thiffault, Scott T. Younger, Tom Curran, Aaron M. Wenger, Elin Grundberg, Tomi Pastinen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Long-read HiFi genome sequencing allows for accurate detection and direct phasing of single nucleotide variants, indels, and structural variants. Recent algorithmic development enables simultaneous detection of CpG methylation for analysis o
Externí odkaz:
https://doaj.org/article/10ee8f5178214fda98a06dc46647c12e
Autor:
Chelsea M. Hosey, Kelsee Halpin, Valentina Shakhnovich, Chengpeng Bi, Brooke Sweeney, Yun Yan, J. Steven Leeder
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 4, Pp 912-922 (2022)
Abstract An accurate understanding of the changes in height and weight of children with age is critical to the development of models predicting drug concentrations in children (i.e., physiologically‐based pharmacokinetic models). However, curves de
Externí odkaz:
https://doaj.org/article/7fd9eec15368404abbd7320faa93aa49
Autor:
Emily Farrow, Isabelle Thiffault, Ana Cohen, Tricia Zion, Adam Walter, Margaret Gibson, Chengpeng Bi, Warren Cheung, Jeffrey Johnston, Tomi Pastinen
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100505- (2023)
Externí odkaz:
https://doaj.org/article/284018338729483dad18fd58f3d3eeb1
Autor:
Bianca D. vanGroen, Chengpeng Bi, Roger Gaedigk, Vincent S. Staggs, Dick Tibboel, Saskia N. deWildt, J. Steven Leeder
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 3, Pp 509-519 (2020)
The hepatic influx transporter OATP1B1 (SLCO1B1) plays an important role in the disposition of endogenous substrates and drugs prescribed to children. Alternative splicing increases the diversity of protein products from > 90% of human genes and may
Externí odkaz:
https://doaj.org/article/9069fc736bc846cc8c626e5568d65a63
Autor:
Egor Dolzhenko, Adam English, Harriet Dashnow, Guilherme De Sena Brandine, Tom Mokveld, William J. Rowell, Caitlin Karniski, Zev Kronenberg, Matt C. Danzi, Warren Cheung, Chengpeng Bi, Emily Farrow, Aaron Wenger, Verónica Martínez-Cerdeño, Trevor D Bartley, Peng Jin, David Nelson, Stephan Zuchner, Tomi Pastinen, Aaron R. Quinlan, Fritz J. Sedlazeck, Michael A Eberle
Tandem repeat (TR) variation is associated with gene expression changes and over 50 rare monogenic diseases. Recent advances in sequencing have enabled accurate, long reads that can characterize the full-length sequence and methylation profile of TRs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c859aeeec905375384cc40c04ab1aa
https://doi.org/10.1101/2023.05.12.540470
https://doi.org/10.1101/2023.05.12.540470
Autor:
Byunggil Yoo, Warren Cheung, Irina Pushel, Lisa Lansdon, Chengpeng Bi, Erin Guest, Tomi Pastinen, Midhat Farooqi
Publikováno v:
Cancer Research. 83:243-243
Genetic characterization of pediatric cancer samples clinically for diagnostic, prognostic, or therapeutic information currently relies on an assortment of methods that complement and partially overlap one another, such as fluorescence in situ hybrid
Autor:
Chelsea M. Hosey, Kelsee Halpin, Valentina Shakhnovich, Chengpeng Bi, Brooke Sweeney, Yun Yan, J. Steven Leeder
Publikováno v:
Clinical and translational science. 15(4)
An accurate understanding of the changes in height and weight of children with age is critical to the development of models predicting drug concentrations in children (i.e., physiologically-based pharmacokinetic models). However, curves describing th
Autor:
Vincent S. Staggs, Dick Tibboel, Saskia N. de Wildt, Roger Gaedigk, Chengpeng Bi, J. Steven Leeder, Bianca D van Groen
Publikováno v:
Cts-Clinical and Translational Science, 13, 509-519
Cts-Clinical and Translational Science, 13, 3, pp. 509-519
Clinical and Translational Science, 13(3), 509-519. Wiley-Blackwell Publishing Ltd
Clinical and Translational Science, Vol 13, Iss 3, Pp 509-519 (2020)
Clinical and Translational Science
Cts-Clinical and Translational Science, 13, 3, pp. 509-519
Clinical and Translational Science, 13(3), 509-519. Wiley-Blackwell Publishing Ltd
Clinical and Translational Science, Vol 13, Iss 3, Pp 509-519 (2020)
Clinical and Translational Science
Contains fulltext : 220573.pdf (Publisher’s version ) (Open Access) The hepatic influx transporter OATP1B1 (SLCO1B1) plays an important role in the disposition of endogenous substrates and drugs prescribed to children. Alternative splicing increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd54fbdad74435ff55d5780fa09deee
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/220573
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/220573
Autor:
Richard Meier, Brooke L. Fridley, J. Steven Leeder, Daniel P. Heruth, Shui Qing Ye, Chengpeng Bi, Roger Gaedigk
Publikováno v:
Pharmacogenetics and Genomics
Supplemental Digital Content is available in the text.
Objectives The majority of drug dosing studies are based on adult populations, with modification of the dosing for children based on size and weight. This rudimentary approach for drug dosin
Objectives The majority of drug dosing studies are based on adult populations, with modification of the dosing for children based on size and weight. This rudimentary approach for drug dosin
Publikováno v:
Drug Metabolism and Disposition. 44:1020-1026
Members of the human CYP3A family of metabolizing enzymes exhibit developmental changes in expression whereby CYP3A7 is expressed in fetal tissues, followed by a transition to expression of CYP3A4 in the first months of life. Despite knowledge about