Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chenglu Yang"'
Autor:
Jian Huang, Ting Zhang, Julia Kalashova, Jinhua Li, Chenglu Yang, Linsheng Zhong, Xiaohu Zhou, Qiong Shi, Gang Lv, Jiadai Chenyu, Yidan Xia Abuliezi, Duo Yu, Xuejiao Jiang, Mallu Chenna Reddy, Namrta Choudhry, Naganna Nimishetti, Dun Yang
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 11, Iss , Pp 100145- (2024)
Mitotic kinesin-like protein 2 (MKLP2/KIF20A) is a key mitotic regulator frequently overexpressed in human malignancies and its abundance is positively correlated with poor outcomes of the disease. Despite extensive research on MKLP2 as a potential t
Externí odkaz:
https://doaj.org/article/a027eb80fad1449fb931fbcbb6238dde
Autor:
Julia Kalashova, Chenglu Yang, Hongmei Li, Yan Long, Duo Yu, Ting Zhang, Xumei Liu, Namrta Choudhry, Qiong Shi, Thaddeus D Allen
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0293283 (2023)
The mitotic regulator, Aurora kinase B (AURKB), is frequently overexpressed in malignancy and is a target for therapeutic intervention. The compound, LXY18, is a potent, orally available small molecule that inhibits the proper localization of AURKB d
Externí odkaz:
https://doaj.org/article/e209cd7f6ecd455c893a06d9bd522ee4
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed serious threats to global health and economy and calls for the development of safe treatments and effective vaccines.
Externí odkaz:
https://doaj.org/article/d71c757d4464472a8a0c7fd1c4ff49a1
Publikováno v:
Transportation Research Part F: Traffic Psychology and Behaviour. 93:248-265
Autor:
Qiong Shi, Xuemei Liu, Julia Kalashova, Chenglu Yang, Hongmei Li, Yan Long, Ting Zhang, Shenqiu Zhang, Gang Lv, Jian Huang, Hong Liu, Jing Zhang, Thaddeus D. Allen, Dun Yang
Therapeutic targeting of MYC directly has proven difficult, but several means to target MYC indirectly using a synthetic lethal drug approach have been proposed. Synthetic lethal approaches for MYC have sought to take advantage of vulnerabilities MYC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01ea282d159ba55216a310199b9a6854
https://doi.org/10.1101/2023.04.03.535438
https://doi.org/10.1101/2023.04.03.535438
Autor:
Jian Huang, Qiong Shi, Namrta Choudhry, Hongmei Li, Chenglu Yang, Julia Kalashova, Ziqi Yan, Jinhua Li, Mallu Chenna Reddy, Sridhar Goud Gopala, Shenqiu Zhang, Jing Zhang, Naganna Nimishetti, Dun Yang
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1091-1098
We used mechanism-informed phenotypic screening to identify and optimize compounds that phenocopy the genetic depletion of the mitotic aurora kinase B (AURKB) kinase. After assaying nine aryl fused seven-membered lactam compounds, we identified a hit
Autor:
Jinhua Li, Ting Zhang, Qiong Shi, Gang Lv, Xiaohu Zhou, Namrta Choudhry, Julia Kalashova, Chenglu Yang, Hongmei Li, Yan Long, Balasubramaniyan Sakthivel, Naganna Nimishetti, Hong Liu, Thaddeus D. Allen, Jing Zhang, Dun Yang
We investigated a novel 4-phenoxy-quinoline-based scaffold that mislocalizes the essential mitotic kinase, AURKB. Here, we evaluated the impact of halogen substitutions (F, Cl, Br, I) on this scaffold with respect to various drug parameters. Br-subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::626e1346f3afcfab41dc510ef38b470f
https://doi.org/10.1101/2023.01.29.526078
https://doi.org/10.1101/2023.01.29.526078
Publikováno v:
Technological Forecasting and Social Change. 189:122371
Autor:
Gang Lv, Qiong Shi, Ting Zhang, Jinhua Li, Yan Long, Wenhui Zhang, Namrta Choudhry, Kevin Yang, Hongmei Li, Julia Kalashova, Chenglu Yang, Xiaohu Zhou, Mallu Chenna Reddy, Kishore Kumar Anantoju, Shenqiu Zhang, Jing Zhang, Thaddeus D. Allen, Hong Liu, Naganna Nimishetti, Dun Yang
Publikováno v:
Bioorganic & Medicinal Chemistry. 80:117173
Autor:
Gang Lv, Qiong Shi, Ting Zhang, Jinhua Li, Julia Kalashova, Yan Long, Yin Sun, Chao Li, Namrta Choudhry, Hongmei Li, Chenglu Yang, Xiaohu Zhou, Mallu Chenna Reddy, Kishore Kumar Anantoju, Rajesh Jupelli, Shenqiu Zhang, Jing Zhang, Thaddeus Allen, Hong Liu, Naganna Nimishetti, Dun Yang
Publikováno v:
European Journal of Medicinal Chemistry. 245:114904
Activity-based drug screens have successfully led to the development of various inhibitors of the catalytic activity of aurora kinases (AURKs), major regulatory kinases of cell division. Disrupting the localization of AURKB, rather than its catalytic