Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Chenglai Fu"'
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1 (IP6K1), governs the degrada
Externí odkaz:
https://doaj.org/article/0e734578ed0f4d43ba683f16eaca8bd9
Autor:
Ji Qi, Weiwei Cheng, Zhe Gao, Yuanyuan Chen, Megan L. Shipton, David Furkert, Alfred C. Chin, Andrew M. Riley, Dorothea Fiedler, Barry V.L. Potter, Chenglai Fu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114449- (2023)
The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the mechanisms of action have been elusive. Here we report that itraconazole disrupts focal adhesion dynamics and cytoskeletal remodeling, which requires 5-diphosphoin
Externí odkaz:
https://doaj.org/article/aaf32d0eb0ef450baf10f427f23f6b17
Autor:
Chenglai Fu, Tomas Rojas, Alfred C. Chin, Weiwei Cheng, Isaac A. Bernstein, Lauren K. Albacarys, William W. Wright, Solomon H. Snyder
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Inositol hexakisphosphate kinase-1 (IP6K1) is required for male fertility, but the underlying mechanisms have been elusive. Here, we report that IP6K1 is required for multiple aspects of male germ cell development. This development requires
Externí odkaz:
https://doaj.org/article/f739f70dc2034291be1474b5f19655c4
Autor:
Weiwei Cheng, Shaopeng Wang, Alexander A. Mestre, Chenglai Fu, Andres Makarem, Fengfan Xian, Lindsey R. Hayes, Rodrigo Lopez-Gonzalez, Kevin Drenner, Jie Jiang, Don W. Cleveland, Shuying Sun
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Hexanucleotide GGGGCC repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here the authors show that (GGGGCC) n translation can initiate without a 5′-cap, and this ca
Externí odkaz:
https://doaj.org/article/621c0d12d9364a1fa8644f3df71f58af
Autor:
Prasun Guha, Richa Tyagi, Sayan Chowdhury, Luke Reilly, Chenglai Fu, Risheng Xu, Adam C. Resnick, Solomon H. Snyder
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2692-2703.e7 (2019)
Summary: Autophagy plays a broad role in health and disease. Here, we show that inositol polyphosphate multikinase (IPMK) is a prominent physiological determinant of autophagy and is critical for liver inflammation and regeneration. Deletion of IPMK
Externí odkaz:
https://doaj.org/article/8238ea2ad4bc49aebaa770600cacd189
Publikováno v:
eLife, Vol 5 (2016)
Blockade of lysosomal calcium release due to lysosomal lipid accumulation has been shown to inhibit mTORC1 signaling. However, the mechanism by which lysosomal calcium regulates mTORC1 has remained undefined. Herein we report that proper lysosomal ca
Externí odkaz:
https://doaj.org/article/1b640903c1c149ae876015d8953653d1
Autor:
Zhenjiu Zhu, Chenglai Fu, Xiaoxia Li, Yimeng Song, Chenghong Li, Minghui Zou, Youfei Guan, Yi Zhu
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23554 (2011)
Prostaglandin E2 (PGE2) has been reported to modulate angiogenesis, the process of new blood vessel formation, by promoting proliferation, migration and tube formation of endothelial cells. Endothelial progenitor cells are known as a subset of circul
Externí odkaz:
https://doaj.org/article/74b0b1db874842729e5989445791e947
Autor:
Robin A. Felder, Chenglai Fu, Andrew M. Riley, Dorothea Fiedler, David Furkert, Solomon H. Snyder, Christopher Wittwer, Evan R. Semenza, Barry V. L. Potter, Zhe Gao, Henning J. Jessen, Amit K. Dutta, Alfred C. Chin, Tomas Rojas, Jennifer L. Pluznick
Publikováno v:
Science Advances
5-InsP7 is an endogenous negative regulator of Na+/K+-ATPase.
Sodium/potassium-transporting adenosine triphosphatase (Na+/K+-ATPase) is one of the most abundant cell membrane proteins and is essential for eukaryotes. Endogenous negative regulato
Sodium/potassium-transporting adenosine triphosphatase (Na+/K+-ATPase) is one of the most abundant cell membrane proteins and is essential for eukaryotes. Endogenous negative regulato
Autor:
Tomas Rojas, Alfred C. Chin, Chenglai Fu, Lauren K. Albacarys, Isaac A. Bernstein, William W. Wright, Solomon H. Snyder, Weiwei Cheng
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Inositol hexakisphosphate kinase-1 (IP6K1) is required for male fertility, but the underlying mechanisms have been elusive. Here, we report that IP6K1 is required for multiple aspects of male germ cell development. This development requires selective
Autor:
Jie Jiang, Shaopeng Wang, Rodrigo Lopez-Gonzalez, Alexander A. Mestre, Shuying Sun, Don W. Cleveland, Lindsey R. Hayes, Kevin Drenner, Chenglai Fu, Andres Makarem, Weiwei Cheng, Fengfan Xian
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature communications, vol 9, iss 1
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications
Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC)n-containing RNAs