Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Chengjuan, Chen"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 10, Pp 4185-4201 (2023)
Monocytes are key effectors in autoimmunity-related diseases in the central nervous system (CNS) due to the critical roles of these cells in the production of proinflammatory cytokines, differentiation of T-helper (Th) cells, and antigen presentation
Externí odkaz:
https://doaj.org/article/f2d2564b1d84477dbba54b4abba92457
Autor:
Gaona Shi, Yu Zhou, Wenshuai Liu, Chengjuan Chen, Yazi Wei, Xinlong Yan, Lei Wu, Weiwei Wang, Lan Sun, Tiantai Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2778-2794 (2023)
Tolerogenic dendritic cells (tolDCs) facilitate the suppression of autoimmune responses by differentiating regulatory T cells (Treg). The dysfunction of immunotolerance results in the development of autoimmune diseases, such as rheumatoid arthritis (
Externí odkaz:
https://doaj.org/article/29fdddd46e6440ee884d46b379a326f3
Autor:
Shuai Shao, Huan Xia, Min Hu, Chengjuan Chen, Junmin Fu, Gaona Shi, Qinglan Guo, Yu Zhou, Wenjie Wang, Jiangong Shi, Tiantai Zhang
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-11 (2020)
Abstract Background Isotalatizidine is a representative C19-diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases on account of its analgesic, anti-inflammatory, anti-rheu
Externí odkaz:
https://doaj.org/article/2796c883d6434012a29172576a513aae
Autor:
Min Hu, Chengbo Xu, Chao Yang, Hongli Zuo, Chengjuan Chen, Dan Zhang, Gaona Shi, Wenjie Wang, Jiangong Shi, Tiantai Zhang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-12 (2019)
Abstract Background The JAK2-STAT signaling pathway plays a critical role in myeloproliferative neoplasms (MPN). An activating mutation in JAK2 (V617F) is present in ~ 95% of polycythemia vera, essential thrombocythemia, and primary myelofibrosis cas
Externí odkaz:
https://doaj.org/article/392e6ca4521848d291b94432d3c713e2
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background: Dendritic cells (DCs) are antigen-presenting cells that play a pivotal role in adaptive cell-mediated immunity by priming and activating T cells against specific tumour and pathogenic antigens. Methotrexate (MTX), a folate derivative, fun
Externí odkaz:
https://doaj.org/article/ebd509183ad54ec5bc144479e05b19ba
Publikováno v:
Molecules, Vol 26, Iss 16, p 5075 (2021)
Monopolar spindle 1 (Mps1), a dual-specific kinase, is related to the proper execution of chromosome biorientation and mitotic checkpoint signaling. The overexpression of Mps1 promotes the occurrence of cancer or the survival of aneuploid cancer cell
Externí odkaz:
https://doaj.org/article/5d4c6f86ee994bd2a8f798ce4e3e0636
Autor:
Yu Zhou, Manru Li, Tao Shen, Tianming Yang, Gaona Shi, Yazi Wei, Chengjuan Chen, Dongmei Wang, Yanan Wang, Tiantai Zhang
Publikováno v:
ACS Chemical Biology. 17:2734-2743
Celastrol (CEL), a pentacyclic triterpene compound, has been proven to have a definite antipulmonary fibrosis effect. However, its direct targets for antipulmonary fibrosis remain unknown. In this study, we designed and synthesized a series of celast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce5e549c2093e39c9bd377ceba653a1
https://doi.org/10.1021/acschembio.2c00099
https://doi.org/10.1021/acschembio.2c00099
Publikováno v:
Expert Opinion on Therapeutic Patents. 32:225-242
Up to now, a total of eight Janus kinase (JAK) inhibitors have been approved for the treatment of autoimmune and myeloproliferative disease. The JAK family belongs to the non-receptor tyrosine kinase family, consisting of JAK1, JAK2, JAK3, and Tyk2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d355cd6f4870c6be0904f2e7a90170b
https://doi.org/10.1080/13543776.2022.2023129
https://doi.org/10.1080/13543776.2022.2023129
Autor:
Jinze Li, Xiaowei Ma, Yu Wang, Chengjuan Chen, Min Hu, Linlin Wang, Junmin Fu, Gaona Shi, Dongming Zhang, Tiantai Zhang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Neuroinflammatory reactions mediated by microglia and astrocytes have been shown to play a key role in early progression of Alzheimer’s disease (AD). Increased evidences have demonstrated that neurons exacerbate local inflammatory reactions by prod
Externí odkaz:
https://doaj.org/article/eb1a668134af417e8f4bc33f3e178c08
Autor:
Chengjuan Chen, Yuan Yin, Gaona Shi, Yu Zhou, Shuai Shao, Yazi Wei, Lei Wu, Dayong Zhang, Lan Sun, Tiantai Zhang
Publikováno v:
Science Advances. 8
Janus kinases (JAKs) play a critical role in immune responses by relaying signals from more than 50 cytokines, making them attractive therapeutic targets for autoimmune diseases. Although approved JAK inhibitors have demonstrated clinical efficacy, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a876a5d95ce53c2fd182d486f162ec1a
https://doi.org/10.1126/sciadv.abo4363
https://doi.org/10.1126/sciadv.abo4363