Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chengjian Hou"'
Autor:
Jingyu Zhang, Zhenzhen Wang, Zhijun Song, Loganathan Karthik, Chengjian Hou, Guoliang Zhu, Lan Jiang, Jianying Han, Rong Ma, Li Li, Lixin Zhang, Xueting Liu, Tom Hsiang
Publikováno v:
Synthetic and Systems Biotechnology, Vol 4, Iss 4, Pp 173-179 (2019)
Microbes serve as the most important resource for drug discovery. During our screening for bioactive compounds from our natural products library, a pathogenic fungus, Microdochium majus strain 99049, from wheat was selected for further investigation.
Externí odkaz:
https://doaj.org/article/166eb5bc06c846199540d88a7cf5acd3
Autor:
Kee Wee, Tan, Pengfei, Ji, Zichen, Qian, Qiao, Gao, Shuai, Wang, Qin, Li, Mingzhu, Gu, Qi, Zhang, Chengjian, Hou, Yang, Huang, Dujuan, Lian, Junghao, Wang, Zheng, Zhang, Sam, Zhang, Jiansheng, Wu, Weichang, Zhou
Publikováno v:
Biotechnology and Bioengineering.
Since the COVID-19 outbreak, unconventional cell line development (CLD) strategies have been taken to enable development of SARS-CoV-2-neutralizing antibodies at expedited speed. We previously reported a novel Chemistry, Manufacturing, and Control (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575f6fcce0e4959d47488f7ae4c15936
https://doi.org/10.1002/bit.28302
https://doi.org/10.1002/bit.28302
Autor:
Xueting Liu, Ronald J. Quinn, Jianying Han, Loganathan Karthik, Zhixin Wang, Tom Hsiang, Xuyuan Wang, Jie Zhang, Liya Zhao, Zhanren Cong, Lan Jiang, Huanqin Dai, Biao Ren, Weize Yuan, Chengjian Hou, Xiangyang Liu, Gao-Yi Tan, Lei Ma, Lixin Zhang, Xue Zhang, Xuekui Xia, Xiangyin Chen, Guang Liu, Xinye Wang, Huanting Yang, Mei Liu, Guoliang Zhu, Shu-Shan Gao, Kangjie Lv
Publikováno v:
Applied Microbiology and Biotechnology. 105:5407-5417
Fungal terpenoids catalyzed by bifunctional terpene synthases (BFTSs) possess interesting bioactive and chemical properties. In this study, an integrated approach of genome mining, heterologous expression, and in vitro enzymatic activity assay was us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4084ae1b083a73a7c0950afe59022af6
https://doi.org/10.1007/s00253-021-11192-3
https://doi.org/10.1007/s00253-021-11192-3
Autor:
Huanqin Dai, Mei Liu, Jian Wang, Lixin Zhang, Xueting Liu, Chengjian Hou, Xiao-Long Ma, Jin-Ping Li, Jie Zhang, Rong Ma, Wanying Lu, Zhiheng Liu, Kan Ding, Biao Ren, Li Zhang
Publikováno v:
Applied Microbiology and Biotechnology
The current global demand for novel anti-TB drugs has drawn urgent attention on the discovery of natural product compounds with anti-TB activity. Lots of efforts have emphasized on environmental samples from unexplored or underexplored natural habits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64d8c8c2e3e9ed5d4410b333369c7f3
https://doi.org/10.1007/s00253-020-10842-2
https://doi.org/10.1007/s00253-020-10842-2
Autor:
Kangjie Lv, Weize Yuan, Xueting Liu, Loganathan Karthik, Wang Zhenzhen, Bixiao Li, Biao Ren, Jie Zhang, Huanqin Dai, Zhanren Cong, Lan Jiang, Wanying Lu, Guoliang Zhu, Tom Hsiang, Lixin Zhang, Chengjian Hou
Publikováno v:
Chemical Communications. 56:10171-10174
Two pairs of dibenzospiroketal racemates, (±)-epicospirocin A (1a/1b) and (±)-1-epi-epicospirocin A (2a/2b), and two (+)-enantiomers of aspermicrones, ent-aspermicrone B (3b) and ent-aspermicrone C (4b), together with two hemiacetal epimeric mixtur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c28d4d6bdad6b47163ab09b62f1618
https://doi.org/10.1039/d0cc03990j
https://doi.org/10.1039/d0cc03990j
Autor:
Jie Zhang, Lixin Zhang, Li Li, Rong Ma, Xueting Liu, Chengjian Hou, Loganathan Karthik, Lan Jiang, Zhijun Song, Wang Zhenzhen, Guoliang Zhu, Jianying Han, Tom Hsiang
Publikováno v:
Synthetic and Systems Biotechnology
Synthetic and Systems Biotechnology, Vol 4, Iss 4, Pp 173-179 (2019)
Synthetic and Systems Biotechnology, Vol 4, Iss 4, Pp 173-179 (2019)
Microbes serve as the most important resource for drug discovery. During our screening for bioactive compounds from our natural products library, a pathogenic fungus, Microdochium majus strain 99049, from wheat was selected for further investigation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84332a7bc5b9b57430dcf7dc9b124733
http://europepmc.org/articles/PMC6807035
http://europepmc.org/articles/PMC6807035
Autor:
Lan, Jiang, Guoliang, Zhu, Jianying, Han, Chengjian, Hou, Xue, Zhang, Zhixin, Wang, Weize, Yuan, Kangjie, Lv, Zhanren, Cong, Xinye, Wang, Xiangyin, Chen, Loganathan, Karthik, Huanting, Yang, Xuyuan, Wang, Gaoyi, Tan, Guang, Liu, Liya, Zhao, Xuekui, Xia, Xiangyang, Liu, Shushan, Gao, Lei, Ma, Mei, Liu, Biao, Ren, Huanqin, Dai, Ronald J, Quinn, Tom, Hsiang, Jingyu, Zhang, Lixin, Zhang, Xueting, Liu
Publikováno v:
Applied microbiology and biotechnology. 105(13)
Fungal terpenoids catalyzed by bifunctional terpene synthases (BFTSs) possess interesting bioactive and chemical properties. In this study, an integrated approach of genome mining, heterologous expression, and in vitro enzymatic activity assay was us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::feae7bd7351c0f9f2f9bf2a9a16781fb
https://pubmed.ncbi.nlm.nih.gov/34155529
https://pubmed.ncbi.nlm.nih.gov/34155529
Autor:
Lixin Zhang, Jiakun Liu, Linquan Bai, Yaojun Tong, Chunbo Lou, Liming Ouyang, Xiangyin Chen, Gil Alterovitz, Xuekui Xia, Bin Hu, Xueting Liu, Guoliang Zhu, Loganathan Karthik, Leshi Liu, Chengjian Hou, Xiaoqian Zeng, Weishan Wang, Gao-Yi Tan, Mindong Liang
Directly cloning of biosynthetic gene clusters (BGCs) from microbial genomes has been revolutionizing the natural product-based drug discovery. However, it is still very challenging to efficiently clone, for example, large (> 80kb) and GC-rich (> 70%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4275244a8a894dd719680fb019606bd8
https://doi.org/10.1101/2020.06.25.170191
https://doi.org/10.1101/2020.06.25.170191
Autor:
Lan Jiang, Xueting Liu, Mei Liu, Loganathan Karthik, Lixin Zhang, Tom Hsiang, Chengjian Hou, Miaomiao Liu, Xin Ye, Huanqin Dai, Qin Yujie, Jie Zhang, Bixiao Li, Guoliang Zhu
Publikováno v:
Applied microbiology and biotechnology. 104(4)
Marine microorganisms live in dramatically different environments and have attracted much attention for their structurally unique natural products with potential strong biological activity. Based on the one strain-many compounds (OSMAC) strategy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507ce3f42cc4ae38fb8eff8e1f287202
https://pubmed.ncbi.nlm.nih.gov/31894364
https://pubmed.ncbi.nlm.nih.gov/31894364
Autor:
Xueting Liu, Guoliang Zhu, Jianying Han, Lixin Zhang, Xuekui Xia, Jiansen Hu, Miaomiao Liu, Lan Jiang, Ronald J. Quinn, Tom Hsiang, Zhijun Song, Chengjian Hou, Yunjiang Feng, Jie Zhang
Publikováno v:
Applied microbiology and biotechnology. 103(13)
Halogen substituents are important for biological activity in many compounds. Genome-based mining of halogenase along with its biosynthetic gene cluster provided an efficient approach for the discovery of naturally occurring organohalogen compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86ba4926135cff223553daf16760743
https://pubmed.ncbi.nlm.nih.gov/31001746
https://pubmed.ncbi.nlm.nih.gov/31001746