Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chenghui, Ren"'
Autor:
Xingzhi Song, John V. Heymach, Carrie Meng, Xiaoshan Zhang, Chenghui Ren, Jing Wang, Funda Meric-Bernstam, Jack A. Roth, Ara A. Vaporciyan, Yi Xu, Shuhong Wu, Stephen G. Swisher, Apar Pataer, Bingliang Fang, Huiqin Chen, Yixin Yao, Cliona M. Rooney, Richard E. Champlin, Michael L. Wang, Wencai Ma, Hua He, Ran Zhang, Jianhua Zhang, M. James You
Publikováno v:
Blood Advances. 6:891-901
Epstein-Barr virus–positive (EBV-positive) B-cell lymphomas are common in immunocompromised patients and remain an unmet medical need. Here we report that MDM2 inhibitors (MDM2is) navtemadlin and idasanutlin have potent in vivo activity in EBV-posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e31ab0199c47a37e10214c952418a6c
https://doi.org/10.1182/bloodadvances.2021006156
https://doi.org/10.1182/bloodadvances.2021006156
Autor:
Longfei Ren, Kuo Qi, Jun Yan, Jun Zhu, Xun Li, Honglong Zhang, Xuhong Chang, Junliang Li, Chenghui Ren, Zhongtian Bai, Ye Xie
Publikováno v:
Toxicology Letters. 355:62-81
The heavy metal cadmium (Cd) can induce damage in liver and liver cancer cells; however, the mechanism underlying its toxicity needs to be further verified in vivo. We daily administered CdCl2 to adult male rats at different dosages via gavage for 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2deb1e581de6711234394d82ae9a8242
https://doi.org/10.1016/j.toxlet.2021.11.004
https://doi.org/10.1016/j.toxlet.2021.11.004
Autor:
Victoria M. Raymond, Junqin He, John V. Heymach, Xiaoshan Zhang, Jing Wang, Lemei Hu, Hai T. Tran, Alexa B. Schrock, Ferdinandos Skoulidis, Jhanelle E. Gray, Bingliang Fang, Monique B. Nilsson, Jianjun Zhang, Susan Varghese, Simon Heeke, Waree Rinsurongkawong, J. Kevin Hicks, Jennifer Saam, Yasir Elamin, R. S. K. Vijayan, Hibiki Udagawa, Heather Lin, Russell Madison, Min Jin Ha, Lixia Diao, Lingzhi Hong, Xiuning Le, Alissa Poteete, Chenghui Ren, Fahao Zhang, Cross Jason, Jacqulyne P. Robichaux, Xiaoke Liu
Publikováno v:
Nature. 597:732-737
Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18–21 and are established driver mutations in non-small cell lung cancer (NSCLC)1–3. Targeted therapies are approved for patients with ‘classical’ mutations and a smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19405880d94ff0c514d62ed4c4c5659f
https://doi.org/10.1038/s41586-021-03898-1
https://doi.org/10.1038/s41586-021-03898-1
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(11)
Cadmium is a ubiquitous environmental toxicant that can cause liver steatosis and nonalcoholic fatty liver disease (NAFLD) on long-term exposure. Sixteen Sprague Dawley rats were randomly divided into two groups, and were administered normal saline a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad2b541da1156ae61d1f4bba281bfa9
https://pubmed.ncbi.nlm.nih.gov/34696656
https://pubmed.ncbi.nlm.nih.gov/34696656
Autor:
Jacqulyne P, Robichaux, Xiuning, Le, R S K, Vijayan, J Kevin, Hicks, Simon, Heeke, Yasir Y, Elamin, Heather Y, Lin, Hibiki, Udagawa, Ferdinandos, Skoulidis, Hai, Tran, Susan, Varghese, Junqin, He, Fahao, Zhang, Monique B, Nilsson, Lemei, Hu, Alissa, Poteete, Waree, Rinsurongkawong, Xiaoshan, Zhang, Chenghui, Ren, Xiaoke, Liu, Lingzhi, Hong, Jianjun, Zhang, Lixia, Diao, Russell, Madison, Alexa B, Schrock, Jennifer, Saam, Victoria, Raymond, Bingliang, Fang, Jing, Wang, Min Jin, Ha, Jason B, Cross, Jhanelle E, Gray, John V, Heymach
Publikováno v:
Nature. 597(7878)
Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18-21 and are established driver mutations in non-small cell lung cancer (NSCLC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::690751a83c5308106525e50e6aa28f32
https://pubmed.ncbi.nlm.nih.gov/35590196
https://pubmed.ncbi.nlm.nih.gov/35590196
Autor:
Xiaoshan, Zhang, Ran, Zhang, Huiqin, Chen, Li, Wang, Chenghui, Ren, Apar, Pataer, Shuhong, Wu, Qing H, Meng, Min Jin, Ha, Jeffrey, Morris, Yuanxin, Xi, Jing, Wang, Jianhua, Zhang, Don L, Gibbons, John V, Heymach, Funda, Meric-Bernstam, John, Minna, Stephen G, Swisher, Jack A, Roth, Bingliang, Fang
Publikováno v:
Am J Cancer Res
Activating mutations of the KRAS gene are one of the major genomic alterations associated with tumorigenesis of non-small cell lung cancer (NSCLC). Thus far, treatment of KRAS-mutant NSCLC remains an unmet medical need. We determined the in vivo trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0bcbd421c9cb0bfbf0986b462e02e62
https://pubmed.ncbi.nlm.nih.gov/33415011
https://pubmed.ncbi.nlm.nih.gov/33415011
Publikováno v:
Toxicology letters. 340
Toxicity caused by the heavy metal Cadmium leads to liver diseases; this finding has generated interest among researchers. We detected DNA methylation using Whole Genome Bisulfite Sequencing (WGBS) to study the relationship between Cadmium exposure a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e7f6455ff792d8d9600cdc662e2772
https://pubmed.ncbi.nlm.nih.gov/33338565
https://pubmed.ncbi.nlm.nih.gov/33338565
Publikováno v:
Information Systems. 70:18-31
In many applications, information is best represented as graphs. In a dynamic world, information changes and so the graphs representing the information evolve with time. We propose that historical graph-structured data be maintained for analytical pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47217aceb5b789eae437ddae424ec3f6
https://doi.org/10.1016/j.is.2017.05.004
https://doi.org/10.1016/j.is.2017.05.004
Autor:
Qing H. Meng, Boris Sepesi, Arlene M. Correa, Wayne L. Hofstetter, Vanessa B. Jensen, Garrett L. Walsh, Yi Xu, David C. Rice, Yungchang Chen, Xiaoshan Zhang, Jack A. Roth, Apar Pataer, John V. Heymach, George T. Pisimisis, Shuhong Wu, Li Wang, Chenghui Ren, Junya Fujimoto, Stephen G. Swisher, Ran Zhang, Reza J. Mehran, Mara B. Antonoff, Bingliang Fang, Ara A. Vaporciyan
Publikováno v:
Cancer
Background Patient-derived xenograft (PDX) models increasingly are used in translational research. However, the engraftment rates of patient tumor samples in immunodeficient mice to PDX models vary greatly. Methods Tumor tissue samples from 308 patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b223ef4cc6b9ca86223006e0d79e7f7e
https://pubmed.ncbi.nlm.nih.gov/31287557
https://pubmed.ncbi.nlm.nih.gov/31287557
Autor:
Yuanxin Xi, John V. Heymach, Li Wang, Bingliang Fang, Funda Meric-Bernstam, Jeffrey S. Morris, Xiaoshan Zhang, Jing Wang, Shuhong Wu, Jack A. Roth, Chenghui Ren, Huiqin Chen, Min Jin Ha, Don L. Gibbons, John D. Minna, Stephen G. Swisher, Ran Zhang
Publikováno v:
Cancer Research. 80:557-557
PDXs recapitulate histologic features, gene expression patterns, and genomic alterations in human primary tumors, and thus have emerged as robust preclinical models for drug development, molecular characterization of cancers, identification of biomar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af69f736085aae21d6f75c527e95cb17
https://doi.org/10.1158/1538-7445.am2020-557
https://doi.org/10.1158/1538-7445.am2020-557