Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Chenghua Gu"'
Autor:
Adam J Granger, Wengang Wang, Keiramarie Robertson, Mahmoud El-Rifai, Andrea F Zanello, Karina Bistrong, Arpiar Saunders, Brian W Chow, Vicente Nuñez, Miguel Turrero García, Corey C Harwell, Chenghua Gu, Bernardo L Sabatini
Publikováno v:
eLife, Vol 9 (2020)
The mouse cerebral cortex contains neurons that express choline acetyltransferase (ChAT) and are a potential local source of acetylcholine. However, the neurotransmitters released by cortical ChAT+ neurons and their synaptic connectivity are unknown.
Externí odkaz:
https://doaj.org/article/46e08e2f33a545e3a225aa162a807d44
Publikováno v:
eLife, Vol 8 (2019)
As an optically transparent model organism with an endothelial blood-brain barrier (BBB), zebrafish offer a powerful tool to study the vertebrate BBB. However, the precise developmental profile of functional zebrafish BBB acquisition and the subcellu
Externí odkaz:
https://doaj.org/article/17e50f7084c54216b67c97a57bfb0ff4
Autor:
Doruk Keskin, Jiha Kim, Vesselina G. Cooke, Chia-Chin Wu, Hikaru Sugimoto, Chenghua Gu, Michele De Palma, Raghu Kalluri, Valerie S. LeBleu
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1066-1081 (2015)
Strategies to target angiogenesis include inhibition of the vessel-stabilizing properties of vascular pericytes. Pericyte depletion in early-stage non-hypoxic tumors suppressed nascent angiogenesis, tumor growth, and lung metastasis. In contrast, per
Externí odkaz:
https://doaj.org/article/78c5858c2c0241b79ce2b93e37d6deb5
Autor:
Esther Kur, Jiha Kim, Aleksandra Tata, Cesar H Comin, Kyle I Harrington, Luciano da F Costa, Katie Bentley, Chenghua Gu
Publikováno v:
eLife, Vol 5 (2016)
Vascular network density determines the amount of oxygen and nutrients delivered to host tissues, but how the vast diversity of densities is generated is unknown. Reiterations of endothelial-tip-cell selection, sprout extension and anastomosis are th
Externí odkaz:
https://doaj.org/article/e8d5328bc849497b9e4e7029d69992ff
Autor:
Weiming Tang, Xiping Huan, Ye Zhang, Tanmay Mahapatra, Jianjun Li, Xiaoyan Liu, Sanchita Mahapatra, Hongjing Yan, Gengfeng Fu, Jinkou Zhao, Chenghua Gu, Roger Detels
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e115691 (2015)
Behavioral interventions (BIs) remained the cornerstone of HIV prevention in resource-limited settings. One of the major concerns for such efforts is the loss-to-follow-up (LTFU) that threatens almost every HIV control program involving high-risk pop
Externí odkaz:
https://doaj.org/article/04a4f07deb7a4fb5a43268ca36bd25b4
Autor:
Maria V Gelfand, Nellwyn Hagan, Aleksandra Tata, Won-Jong Oh, Baptiste Lacoste, Kyu-Tae Kang, Justyna Kopycinska, Joyce Bischoff, Jia-Huai Wang, Chenghua Gu
Publikováno v:
eLife, Vol 3 (2014)
During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process and currently both VEGF and its receptors, VEGFR1, VEGFR2
Externí odkaz:
https://doaj.org/article/3612d88f088b464b8112d62e3eb5797c
Publikováno v:
eLife, Vol 3 (2014)
Synaptic transmission between midbrain dopamine neurons and target neurons in the striatum is essential for the selection and reinforcement of movements. Recent evidence indicates that nigrostriatal dopamine neurons inhibit striatal projection neuron
Externí odkaz:
https://doaj.org/article/186232619a6b452a859d2b870a7b50b9
Autor:
Trevor Krolak, Luke Kaplan, Lujing Chen, Kathleen Navas, Austin Birmingham, Daniel Ryvkin, Victoria Izsa, Chenghua Gu
Publikováno v:
Physiology. 38
The brain is an energetically expensive organ, consuming 20% of the body’s cardiac output at rest while only accounting for 2% of its mass. Unable to store long-term energy reserves, the brain rapidly redistributes blood flow to active regions in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a3c75628a4686248a38d573a6dc0be
https://doi.org/10.1152/physiol.2023.38.s1.5731554
https://doi.org/10.1152/physiol.2023.38.s1.5731554
Autor:
Alyssa Larios, Chenghua Gu
Publikováno v:
Physiology. 38
The brain consumes a disproportionate amount of energy, receiving 20% of the total cardiac output despite accounting for only 2% of the body’s weight. While total cerebral perfusion is homeostatically held constant, the neurovascular network dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08aff903ab07fd6507e8d62cd6023abd
https://doi.org/10.1152/physiol.2023.38.s1.5732872
https://doi.org/10.1152/physiol.2023.38.s1.5732872
Autor:
Trevor Krolak, Ken Y. Chan, Luke Kaplan, Qin Huang, Jason Wu, Qingxia Zheng, Velina Kozareva, Thomas Beddow, Isabelle G. Tobey, Simon Pacouret, Albert T. Chen, Yujia A. Chan, Daniel Ryvkin, Chenghua Gu, Benjamin E. Deverman
Publikováno v:
Nature Cardiovascular Research. 1:389-400
Endothelial cells have a crucial role in nervous system function, and mounting evidence points to endothelial impairment as a major contributor to a wide range of neurological diseases. However, tools to genetically interrogate these cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f567fa4f2622650f49ee7209776e84
https://doi.org/10.1038/s44161-022-00046-4
https://doi.org/10.1038/s44161-022-00046-4